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@article{ART001365085},
author={이상규 and 원재균 and Seung-ryong Yeom and LEE SU KYUNG and SONG YUNG SUN and Young Dal Kwon},
title={The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={3},
pages={15-32}

TY - JOUR
AU - 이상규
AU - 원재균
AU - Seung-ryong Yeom
AU - LEE SU KYUNG
AU - SONG YUNG SUN
AU - Young Dal Kwon
TI - The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 15
EP - 32
SN - 1229-1854
AB - Objectives : The purpose of this Study was to identify the effect of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture on pain control and nerve regeneration after crush injury in rat sciatic nerve. Methods : Neuropathic pain was induced by crush-induced model of right sciatic nerve. Animal groups were divided as follows; Group Ⅰ: no treatment control group, Group Ⅱ : experimental group treated with Dokhwalgisaeng-tang(Duhuoqisheng-tang), Group Ⅲ : experimental group treated with Jungsongouhyul pharmacopuncture, and Group Ⅳ : experimental group treated with Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture. To evaluate pain intensity, each group was observed paw withdrawal threshold and immunoreactivity on the c-fos before and after respective treatments in five hours, first, third, and fifth day. To evaluate nerve regeneration, those were observed SFI(Sciatic Functional Index) and GAP-43(Growth Associated Protein 43) after each treatment in seventh and thirteenth day. Results : 1. Paw withdrawal threshold to the mechanical stimuli made the significant difference between group Ⅳ and the control group after five days of the experiment. 2. Paw withdrawal threshold to the thermal stimuli made the significant difference between group Ⅰ and Ⅲ, Ⅰ and Ⅳ, Ⅱ and Ⅳ. 3. In immunohistochemical response of c-fos, as time passes, the immunoreactivity of all groups was decreased gradually. Especially, group Ⅳ was observed the lowest after three days. 4. The differences of sciatic function indexes in each group were significantly between group Ⅰ and Ⅲ, Ⅰ and Ⅳ, Ⅱ and Ⅳ after 14 days, and between group Ⅰ and Ⅲ, Ⅰ and Ⅳ, Ⅱ and Ⅳ, Ⅲ and Ⅳ after 21 days. 5. In immunohistochemical response of GAP-43, all groups had higher GAP-43 immunoreactivity at the 14 days from post-injury and group Ⅳ showed highest immunoreactivity. Conclusions : Based on above the results, it is proposed that Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture may be helpful as a treatment in neuropathic pain and nerve regeneration in rat model.
KW - Dokhwalgisaeng-tang(Duhuoqisheng-tang);Jungsongouhyul pharmacopuncture;Neuropathic pain;Nerve regeneration
DO -
UR -
ER -

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN and Young Dal Kwon. (2009). The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model. Journal of Korean Medicine Rehabilitation, 19(3), 15-32.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN and Young Dal Kwon. 2009, "The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model", Journal of Korean Medicine Rehabilitation, vol.19, no.3 pp.15-32.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, Young Dal Kwon "The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model" Journal of Korean Medicine Rehabilitation 19.3 pp.15-32 (2009) : 15.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, Young Dal Kwon. The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model. 2009; 19(3), 15-32.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN and Young Dal Kwon. "The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model" Journal of Korean Medicine Rehabilitation 19, no.3 (2009) : 15-32.

이상규; 원재균; Seung-ryong Yeom; LEE SU KYUNG; SONG YUNG SUN; Young Dal Kwon. The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model. Journal of Korean Medicine Rehabilitation, 19(3), 15-32.

이상규; 원재균; Seung-ryong Yeom; LEE SU KYUNG; SONG YUNG SUN; Young Dal Kwon. The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model. Journal of Korean Medicine Rehabilitation. 2009; 19(3) 15-32.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, Young Dal Kwon. The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model. 2009; 19(3), 15-32.

이상규, 원재균, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN and Young Dal Kwon. "The Effects of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration in the Crush-induced Sciatic Nerve Injury of the Rat Model" Journal of Korean Medicine Rehabilitation 19, no.3 (2009) : 15-32.