Neuroprotective Effects of Neutral Pharmacopuncture for Blood Stasis and Tangguisusangami-tang(dangguixusanjiawei-tang ) in the Experimental Traumatic Brain Injury Rats (中性瘀血 藥鍼과 當歸鬚散加味湯이 외상성 뇌손상 흰쥐의 신경보호에 미치는 영향)

정일문; choi jin bong (최진봉)

Neuroprotective Effects of Neutral Pharmacopuncture for Blood Stasis and Tangguisusangami-tang(dangguixusanjiawei-tang ) in the Experimental Traumatic Brain Injury Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2010, 20(1), pp.13-26
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

정일문 ¹, choi jin bong ¹

¹동신대학교

Accredited

ABSTRACT

Objectives :This study was designed to evaluate neuroprotective effects of Neutral Pharmacopuncture for Blood Stasis(NPBS) into SP10 and Tangguisusangami-tang (dangguixusanjiawei-tang)(TGT) in the experimental Traumatic Brain Injury(TBI) rats. Methods :Male rats were divided into 4 groups. Group Ⅰ was no treatment after TBI. Group Ⅱ was treatment with NPBS into SP10 after TBI. Group Ⅲ was treatment with TGT after TBI. Group Ⅳ was NPBS into SP10 and TGT after TBI. The author carried out neurological motor behavioral, histological assessment test. Results :1. In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the Group Ⅱ, Ⅲ, Ⅳ. Also Group Ⅳ was increased as compared with Group Ⅱ, Ⅲ. 2. In BAX expression, according to priority Group Ⅳ, Ⅲ, Ⅱ, Ⅰ were decresed in 7 and 14 days later. Especially Group Ⅳ was significantly decreased in 14days later. 3. In BCL-2 expression, Group Ⅳ was increased slightly in 7days later. Most incresed expression was experimented in the Group Ⅳ in 14days later. 4. In TUNEL expression, Ⅳ was decreased as compared with each Group Ⅰ,Ⅱ, Ⅲ in 7days later. Group Ⅳ, Ⅲ were decreased as compared with each Group Ⅰ,Ⅱ in 14days later. Conclusions :According to the results, NPBS and TGT can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL-2, TUNEL expression. And also can help neurological motor behavioral function.

KEYWORDS

Key words : SP10, Neutral Pharmacopuncture for Blood stasis, Tangguisusangami-tang(dangguixusanjiawei-tang), Neuroprotective effect

Citation status

* References for papers published after 2023 are currently being built.

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6