Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
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Inhibiting Effects of Hwallak-dan(Huoluo-dan ) on the Adjuvant-induced Arthritis in Lewis Rats
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2011, 21(1), pp.79-95
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
김덕희 1, 정수현 2, Seo,Il-bok 2, Kim， Soon-joong 2
1새명대학교
2세명대학교
Accredited
ABSTRACT
Objectives :This study was to investigate the antiarthritic effect of Hwallak-dan(Huoluo-dan) on the complete freund's adjuvant(CFA)-induced arthritis in Lewis rats.
Methods :Arthritis was induced by intradermal injection of CFA into base of tail. Experimental groups divided into normal(n=10), control(n=10) and treated(n=10) group. Animals of control group received normal saline for twenty days, treated group received extracts Hwallak-dan(Huoluo-dan) for same duration, light mineral oil only injected non-arthritic rats were served as normal group. The incidence of arthritis and arthritic index were observed after treatment. Body weight, paw edema volume and thickness of ankle joint were measured at 0, 11, 14, 17, 20 days after treatment. White blood cell(WBC) counts in blood were analysed at 20 days after treatment and tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-6 contents in paw exudate were analysed by ELISA at 20 days after treatment. Histopathology on the ankle joint were performed at 20 days after treatment.
Results :1. Incidence of arthritis of treated group was 60% and control group was 100% at 20 days after treatment.
2. Arthritic index of treated group was significantly decreased compared with control group at 20 days after treatment.
3. Paw edema volume and thickness of ankle joint of treated group was significantly decreased compared with control group at 20 days after treatment.
4. Total WBC of treated group was significantly decreased compared with control group at 20 days after treatment.
5. Neutrophils of treated group was significantly decreased compared with control group at 20 days after treatment.
6. TNF-α content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment.
7. IL-1β content content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment.
8. IL-6 content content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment.
9. Histopathological arthritic index of treated group was significantly decreased compared with control group at 20 days after treatment.
Conclusions :These results indicate that Hwallak-dan(Huoluo-dan) has inhibitory effect on the development and progression of CFA-induced arthritis in rats.
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[journal]
송영욱
/ 2009
/
Updated pathophysiology of rheumatoid arthritis
/ 대한내과학회지
/ 대한내과학회
76(1)
: 1~6
[journal]
Holborow EJ
/ 1964
/ The relationship of autoimmunity to rheumatoid arthritis
/ Proc R Soc Med
57
: 59~62
[journal]
Lee DM
/ 2001
/ Rheumatoid arthritis
/ Lancet
358
: 903~911
[journal]
Smolen JS
/ 2007
/ New therapies for treatment of rheumatoid arthritis
/ Lancet
370(9602)
: 1861~1874
[journal]
Pisetsky DS
/ 2001
/ Progress in the treatment of rheumatoid arthritis
/ JAMA
286(22)
: 2787~2790
[journal]
Lard LR
/ 2001
/ Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies
/ Am J Med
111(6)
: 446~451
[book]
신병철
/ 2005
/ 한방재활의학 second edition
/ 군자출판사
: 96~97
[book]
陳師文
/ 1975
/ 太平惠民和劑局方
/ 旋風出版社
: 14~
[book]
허준
/ 1998
/ 국역증보동의보감
/ 남산당
: 534~
[journal]
강승범
/ 1999
/ 활락단이 항염, 진통 및 항혈전에 미치는 영향에 대한 연구
/ 대한한방내과학회지
20(1)
: 57~72
[journal]
Pearson CM
/ 1956
/ Development of arthritis, periarthritis and periostitis in rats given adjuvant
/ Proc Soc Exp Biol Med
15
: 95~101
[journal]
Brahm E
/ 1991
/ Animal models of rheumatoid arthritis. Clues to etiology and treatment
/ Clin Orthop
265
: 42~53
[journal]
張紹元
/ 1982
/ 生藥에 의한 adjuvant 관절염의 억제
/ 生藥學會誌
36
: 78~81
[journal]
신민식
/ 1994
/ 防風湯이 adjuvant 유발관절염에 미치는 영향
/ 동의물리요법과학회지
4(1)
: 135~146
[journal]
김순중
/ 1997
/ 三氣飮 및 三氣飮去附子가 adjuvant 관절염 유발시 활성산소에 미치는 영향
/ 한방재활의학과학회지
7(2)
: 1~45
[journal]
서해경
/ 2001
/ 獨活寄生湯加猫脛骨이 adjuvant 關節炎에 미치는 影響
/ 한방재활의학과학회지
11(2)
: 111~124
[journal]
조윤형
/ 2002
/ 天授根이 adjuvant 유발관절염에 미치는 영향
/ 한방재활의학과학회지
12(2)
: 175~186
[journal]
김근찬
/ 2004
/ 羌活續斷湯이 adjuvant 유발관절염 동물 model에 미치는 영향
/ 한방재활의학과학회지
14(1)
: 1~18
[journal]
설재욱
/ 2005
/ 麻黃羌活湯이 adjuvant 관절염에 미치는 실험적 효과
/ 한방재활의학과학회지
15(2)
: 55~65
[journal]
손동우
/ 2005
/ 趁痛散이 흰쥐의 adjuvant 유발 관절염 및 척수 내 c-fos 발현에 미치는 영향
/ 한방재활의학과학회지
15(3)
: 25~43
[journal]
Pincus T
/ 1993
/ What is the natural history of rheumatoid arthritis
/ Rheumatic diseases clinics of North America
19(1)
: 123~151
[journal]
Wolfe F
/ 1994
/ The mortality of rheumatoid arthritis
/ Arthritis and rheumatism
37(4)
: 481~494
[journal]
Gay S
/ 1989
/ Immunopathology of rheumatoid arthritis
/ Current opinion in rheumatology
1(1)
: 8~14
[journal]
Klareskog L
/ 1986
/ Reactivity of monoclonal anti-type Ⅱ collagen antibodies with cartilage and synovial tissue in rheumatoid arthritis and osteoarthritis
/ Arthritis and rheumatism
29(6)
: 730~738
[journal]
Hart PH
/ 1989
/ Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor-α, interleukin 1, and prostaglandin E2
/ PNAS
86(10)
: 3803~3807
[journal]
Angel J
/ 1993
/ Interleukin-1-mediated phospholipid breakdown and arachidonic acid release in human synovial cells
/ Arthritis and rheumatism
36(2)
: 158~167
[journal]
McDonnell J
/ 1992
/ Recombinant human interleukin-1β-induced increase in levels of proteoglycans, stromelysin and leukocytes in rabbit synovial fluid
/ Arthritis and rheumatism
35(7)
: 799~805
[book]
해리슨내과학편찬위원회
/ 1997
/ HARRISON’S 내과학
/ 도서출판정담
: 179~1785
[journal]
Houssiau FA
/ 1988
/ Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
/ Arthritis and rheumatism
31(6)
: 784~788
[journal]
Manicourt DH
/ 1993
/ Levels of circulating tumor necrosis factor α and interleukin-6 in patients with rheumatoid arthritis. Relationship to serum levels of hyaluronan and antigenic keratan sulfate
/ Arthritis and rheumatism
36(4)
: 490~499
[book]
양유걸
/ 1991
/ 黃帝內經素問譯解
/ 일중사
: 328~
[book]
華陀
/ 1994
/ 華陀中藏經
/ 自由出版社
: 31~33
[book]
劉完素
/ 1992
/ 金元四大家醫學全書(河間六書)
/ 天津科學技術出版社
: 54~55
[book]
吳謙
/ 1994
/ 醫宗金鑑
/ 大星文化社
: 352~504
[book]
張仲景
/ 1973
/ 金匱要略方論
/ 大聯國風出版社
: 32~33
[book]
張介賓
/ 1975
/ 景岳全書
/ 杏林書院
: 153~159
[book]
權宰植
/ 1993
/ 痺證
/ 鼎談出版社
: 23~29
[journal]
강인수
/ 1990
/ 痺證治療의 用藥에 關한 小考
/ 대한한의학회지
11(1)
: 245~252
[book]
張鐵軍
/ 1997
/ 抗風濕中草彩色圖譜
/ 중국중의약출판사
: 1~
[journal]
이중휘
/ 2001
/ 《方藥合編》에 수록된 비증처방에 대한 연구
/ 대전대한의학연구소논문집
10(1)
: 375~383
[book]
이상인
/ 1981
/ 본초학
/ 수서원
: 321~551
[journal]
Trentham DE
/ 1977
/ Autoimmunity to type II collagen an experimental model of arthritis
/ The journal of experimental medicine
146(3)
: 857~868
[journal]
Noyori K
/ 1994
/ Experimental induction of arthritis in rats immunized with Escherichia coli 0:14 lipopolysaccharide
/ The journal of rheumatology
21(3)
: 484~488
[journal]
Saso Y
/ 2001
/ S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide -induced arthritis
/ The journal of pharmacology and experimental therapeutics
296(1)
: 106~112
[journal]
Søballe K
/ 1991
/ Physical bone changes in carragheenin -induced arthritis bos iated by quantitative computed tomography
/ Skeletal radiology
20(5)
: 345~352
[journal]
Kannan K
/ 2005
/ Animal models of rheumatoid arthritis and their relevance to human disease
/ Pathophysiology
12(3)
: 167~181
[journal]
Bendele A
/ 1999
/ Animal models of arthritis: relevance to human disease
/ Toxicologic pathology
27(1)
: 134~142
[book]
서영석
/ 1999
/ 활락단전탕액이 척수운동신경세포에 미치는 영향
/ 원광대학교대학원
[journal]
송왕기
/ 2001
/
Effects of Hwalrak-dan Water Extract on LDH activity of Cultured
Spinal Sensory neurons Damaged by Hydrogen Peroxide
/ 동의생리병리학회지
/ 대한동의병리학회
15(3)
: 464~468
[journal]
Taurog JD
/ 1988
/ Adjuvant arthritis
/ Methods in enzymology
162
: 339~355
[book]
이귀녕
/ 1993
/ 임상병리파일
/ 의학문화사
: 82~1384
[book]
대한병리학회
/ 1995
/ 병리학
/ 고문사
: 71~1170
[book]
정태호
/ 1996
/ 최신면역학강의
/ 경북대학교출판부
: 10~357
[book]
황상익
/ 1998
/ 면역의 의미론
/ 하늘과학문고
: 43~92
[journal]
Wood NC
/ 1992
/ In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis
/ Clinical immunology and immunopathology
62(3)
: 295~300
[journal]
Chu CQ
/ 1991
/ Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage- pannus junction in patients with rheumatoid arthritis
/ Arthritis and rheumatism
34(9)
: 1125~1132
[book]
서울대학교의과대학
/ 1997
/ 면역학
/ 서울대학교출판부
: 100~262
[journal]
Yaron I
/ 1987
/ Human recombinant interleukin-1 ber stimulates glycosaminoglycan production in human synovial fibroblast cultures
/ Arthritis and rheumatism
30(4)
: 424~430
[book]
Janeway CA
/ 1997
/ Immunobiology: the immune system in health and disease
/ Garland Pub
: 8~14
[journal]
Okamoto H
/ 1997
/ The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor and oncostatin M in rheumatoid arthritis
/ Arthritis and rheumatism
40(6)
: 1096~1105
[journal]
Leisten JC
/ 1990
/ Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic lewis rats treated with cyclosporin A or indomethacin
/ Clinical immunology and immunopathology
56(1)
: 108~115
[journal]
Conforti A
/ 1997
/ Specific and long-lasting suppression of rat adjuvant arthritis by low-dose mycobacterium butyricum
/ European journal of pharmacology
324(2)
: 241~247
[book]
대한정형외과학회
/ 1998
/ 정형외과학
/ 최신의학사
: 55~176