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@article{ART001547389},
author={박정철 and SONG YUN KYUNG and Lim Hyung Ho},
title={Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={2},
pages={1-13}

TY - JOUR
AU - 박정철
AU - SONG YUN KYUNG
AU - Lim Hyung Ho
TI - Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 13
SN - 1229-1854
AB - Objectives :We investigated the effect of Haein-tang(Hairen-tang) on short-term memory and apoptosis in dentate gyrus of the gerbils with transient global ischemia. Methods :For the induction of cerebral ischemia model in mice, common carotid arteries of gerbils were occluded with aneurysm clips for 5 min. One day after operation, Haein-tang(Hairen-tang) was administrated orally injected once a day for 15 consecutive days. Gerbils were randomly divided into four groups(n=10 in each group): sham-operation group, ischemia-induction group, ischemia-induction and 50 mg/kg Haein-tang(Hairen-tang)-treated group, ischemia-induction and 100 mg/kg Haein-tang(Hairen-tang)-treated group, and ischemia-induction and 200 mg/kg Haein-tang(Hairen-tang)-treated group. The effect of Haein-tang(Hairen-tang) on memory function was investigated by using step-down avoidance task. Apoptosis was confirmed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) staining and immunohistochemistry for caspase-3. Western blot analysis for the expressions of Bax and Bcl-2 protein was also conducted. Results :1. Haein-tang extract significantly enhanced short-term memory in step-down avoidance task and 100 mg/kg, 200 mg/kg Haein-tang-treated group. 2. Haein-tang extract significantly suppressed TUNEL-positive cells after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang-treated group. 3. Haein-tang extract significantly increased caspase-3 positive cells in the hippocampal dentate gyrus after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang-treated group. 4. Haein-tang extract significantly decreased Bax protein expressions in the hippocampus after transient global ischemia and 100 mg/kg, 200 mg/kg Haein-tang-treated group. Haein-tang extract significantly increased Bcl-2 protein expressions in the hippocampal dentate gyrus after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang-treated group.Haein-tang extract significantly decreased Ratio of Bax protein to Bcl-2 protein in the hippocampus after transient global ischemia and 100 mg/kg, 200 mg/kg Haein-tang-treated group. Conclusions :While Haein-tang(Hairen-tang) treatment improved short-term memory by suppressing on ischemia-induction apoptosis. In the present study, Haein-tang (Hairen-tang) shows protective effect on transient global ischemia.
KW - Transient global ischemia;Haein-tang(Hairen-tang);Gerbils;Apoptosis
DO -
UR -
ER -

박정철, SONG YUN KYUNG and Lim Hyung Ho. (2011). Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia. Journal of Korean Medicine Rehabilitation, 21(2), 1-13.

박정철, SONG YUN KYUNG and Lim Hyung Ho. 2011, "Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia", Journal of Korean Medicine Rehabilitation, vol.21, no.2 pp.1-13.

박정철, SONG YUN KYUNG, Lim Hyung Ho "Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia" Journal of Korean Medicine Rehabilitation 21.2 pp.1-13 (2011) : 1.

박정철, SONG YUN KYUNG, Lim Hyung Ho. Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia. 2011; 21(2), 1-13.

박정철, SONG YUN KYUNG and Lim Hyung Ho. "Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 1-13.

박정철; SONG YUN KYUNG; Lim Hyung Ho. Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia. Journal of Korean Medicine Rehabilitation, 21(2), 1-13.

박정철; SONG YUN KYUNG; Lim Hyung Ho. Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia. Journal of Korean Medicine Rehabilitation. 2011; 21(2) 1-13.

박정철, SONG YUN KYUNG, Lim Hyung Ho. Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia. 2011; 21(2), 1-13.

박정철, SONG YUN KYUNG and Lim Hyung Ho. "Neuroprotective Effects of Haein-tang(Hairen-tang ) on Decrease of Short-term Memory and Apoptosis in Dentate Gyrus of the Gerbils with Transient Global Ischemia" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 1-13.