Effects of Root of Scutellariae Radix against Inflammatory Response in the Spinal Cord Contusion Injury in Rats (척수압박손상 흰쥐의 척수조직 염증반응에 黃芩이 미치는 영향)

양기영; 최원익; 신정원; Seong-ha Park (박성하); Seong-Joon Kim (김성준); Jongsoo Lee (이종수); SOHN NAK-WON (손낙원)

Effects of Root of Scutellariae Radix against Inflammatory Response in the Spinal Cord Contusion Injury in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2011, 21(3), pp.1-11
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

양기영 ¹, 최원익 ¹, 신정원 ¹, Seong-ha Park ², Seong-Joon Kim ¹, Jongsoo Lee ¹, SOHN NAK-WON ¹

¹경희대학교
²부산대학교

Accredited

ABSTRACT

Objectives :This study was performed to evaluate the effects of root of Scutellariae Radix(SR) water extract against inflammatory response in the spinal cord injury(SCI). Methods :SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rat. SR was orally given once a day for 7days after SCI. Myeloperoxidase(MPO) positive neutrophils infiltration was examined. Inducible nitric oxide synthase(iNOS) and tumor necrosis factor-α(TNF-α) expressions were observed with immunohistochemistry. Glial fibrillary acidic protein(GFAP) positive astrocytes were examined using immuno-fluorescence. Results :1. SR reduced MPO-positive neutrophils infiltration in peri-damage regions of the contusive SCI-induced rats. 2. SR reduced iNOS positive cells in the white matter of the contusive SCI-induced rats. 3. SR reduced TNF-α positive cells in the gray and white matter of the contusive SCI-induced rats. 4. SR reduced cell number and size of astrocytes in peri-damage regions of the contusive SCI-induced rats. Conclusions :These results suggest that SR plays an inhibitory role against inflammatory response in the SCI.

KEYWORDS

Spinal cord injury, Scutellariae Radix, Anti-inflammation, Neutrophil infiltration, iNOS, TNF-α

Citation status

* References for papers published after 2023 are currently being built.

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