Effects of Bangpungtongseong-san(Fangfengtongsheng-san) on the Adjuvant-induced Arthritis in Rats (방풍통성산이 흰쥐의 Adjuvant 유발 관절염에 미치는 영향)

엄관준; Ji-Young Kim (김지영); Kim， Soon-joong (김순중); Seo,Il-bok (서일복); Jeong， Su-hyeon (정수현)

Effects of Bangpungtongseong-san(Fangfengtongsheng-san) on the Adjuvant-induced Arthritis in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2012, 22(2), pp.91-103
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

엄관준 ¹, Ji-Young Kim ², Kim， Soon-joong ³, Seo,Il-bok ³, Jeong， Su-hyeon ³

¹세명대학교 한의과대학 한방재활의학과교실
²세명대학교 한의과대학 한방재활의학과
³세명대학교

Accredited

ABSTRACT

Objectives :This study was carried out to investigate the effects of Bangpungtongseong-san(Fangfengtongsheng-san) treatment on the change of the adjuvant-induced arthritis in rats. Methods :Arthritis was induced by injection of complete Freund's adjuvant(CFA, 0.1 ml) into the tail base of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. The control group was taken distilled water and the treated group, extracts of Bangpungtongseong-san(Fangfengtongsheng-san) by orally for 15 days. At the end of the experiment(28 days after CFA injection), gross and histopathological examinations on the articular structures of ankle joints were performed. The total number of white blood cells was measured by the ADVIA(automated blood cell counter, Bayer Co., Ireland). And also, tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) contents in paw exudate of rats were measured by enzyme-linked immunosorbent assay(ELISA) method. Results :1. Body weight(g) gain rate(%) of the treated group was increased significantly compared with control group at the 15th day after injection. 2. The thickness of ankle joints of the treated group was decreased significantly compared with the control group. 3. Histopathologically, finding of fibrous ankylosis of the treated group was decreased compared with the control group. 4. The total number of white blood cells in the treated group was decreased significantly compared with the control group. 5. TNF-α content and IL-1β content in paw exudate of the treated group were decreased significantly compared with the control group. Conclusions :On the basis of these results, we suggest that Bangpungtongseong-san(Fangfengtongsheng-san) has inhibiting effects on the progression of arthritis in CFA-induced arthritis model.

KEYWORDS

Bangpungtongseong-san(Fangfengtongsheng-san), Adjuvant-induced arthritis, White blood cells, TNF-α, IL-1β

Citation status

* References for papers published after 2023 are currently being built.

[book] 한방재활의학과학회 / 2011 / 한방재활의학 제3판 / 군자출판사 : 84~100

[book] 한태륜 / 2008 / 재활의학 / 군자출판사 : 908~909

[book] Kasper, Braunwald / 2006 / Harrison's 내과학. 제16판 / 도서출판 MIP : 2083~2457

[journal] Morand EF / 2005 / Macrophage migration inhibitory factor in rheumatoid arthritis / Front Biosci 10 : 12~22

[journal] Tracey D / 2008 / Tumor necrosis factor antagonist mechanisms of action : a comprehensive review / Pharmacology & Therapeutics 117(2) : 2443~2479

[journal] Pettit AR / 2006 / RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis / Rheumatology(Oxford) 45 : 1068~1076

[journal] Fleischmann R / 2004 / Anakinra : an inhibitor of IL-1 for the treatment of rheumatoid arthritis / Expert Opinion on Biological Therapy 4 : 1333~1344

[journal] 조상환 / 1989 / 대방풍탕의 진통, 소염 및 해열 작용에 대한 실험적 연구 / 경희의학 5(3) : 322~328

[journal] 정수현 / 2000 / 삼비탕이 Collagen으로 유발된 관절염에 미치는 영향 / 한방재활의학과학회지 10(1) : 173~183

[thesis] 김현석 / 2004 / 삼비탕가미방의 항염작용에 관한 연구 / 석사 / 대전대학교 대학원

[journal] 서윤정 / 2004 / Analgesic effect of Daeganghwal-Tang on a rat model of CFA-induced arthritis / Korean Journal of Acupuncture / 경락경혈학회 21(4) : 83~100

[book] 劉完素 / 1988 / 宣明方論卷十, In 文淵閣書庫全書, 中醫學大系 / 녹강출판사 : 768~

[journal] 석민희 / 2008 / Documentational Study and Observation from the View of Hyungsang Medicine on Bangpungtongseong-san / 동의생리병리학회지 / 대한동의병리학회 22(1) : 51~59

[thesis] 成賢濟 / 1984 / 방풍통성산의 진통·소염·해열 및 항균작용에 관한 실험적 연구 / 박사 / 경희大學校

[book] 許浚 / 2005 / 對譯東醫寶鑑 / 동의보감출판사 : 957~1195

[journal] 김전 / 2002 / Pathophysiology of Pain / 대한신경과학회지 / 대한신경과학회 20(1) : 1~7

[book] Kelly WN / 1985 / Textbook of rheumatology. 2nd / Saunders company : 884~

[book] 대한정형외과학회 / 2005 / 정형외과학. 제5판 / 최신의학사 : 195~201

[book] 김태규 / 2006 / 면역학 / 라이프사이언스 : 347~348

[book] 李梴 / 1985 / 原本編註醫學入門(下) / 남산당 : 12~27

[book] 汪昻 / 1982 / 醫方集解 / 의성당 : 68~

[book] 전국한의과대학 공동교재편찬위원회 / 2005 / 본초학 / 영림사 : 155~633

[journal] 하여태 / 2005 / 가미방풍통성산의 항고혈압 작용 / 대전대학교 한의학연구소 논문집 14(2) : 55~70

[journal] 이남훈 / 1991 / 방풍통성산이 고혈압, 고지혈에 미치는 영향 / 경희의학 7(1) : 101~109

[journal] 이장천 / 2005 / Effects of Gamibangpungtongseungsan on lipid composition and antioxidant in rat fed high fat / 대한본초학회지 / 대한본초학회 20(2) : 69~75

[journal] 황상준 / 2006 / The inhibitory effects of Bangpungtongseoung-san on the obese gene and obded inhibitory about obede-mouse induced by high fat diet / 대한한의학회지 / 대한한의학회 27(1) : 11~22

[journal] Gavrilovic J / 2009 / Fibroblast Growth Factor 2 : A New Key Player in Osteoarthritis / Arthritis & Rheumatism 60(7) : 1869~1872

[journal] Murat N / 2007 / Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score / Acta Orthop Traumatol Turc 41(3) : 233~237

[journal] Kikuchi T / 1998 / Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits / Osteoarthritis Cartilage 6(3) : 177~186

[journal] Mirshafiey A / 2005 / Treatment of Experimental Arthritis with M2000, a Novel Designed Non-Steroidal Anti-inflammatory Drug / Scandinavian Journal of Immunology 61(5) : 435~441

[journal] Horsfall AC / 1997 / Suppression of collagen-induced arthritis by continuous administration of IL-4 / J Immunol 159 : 5687~5696

[journal] Colpaert FC. / 1987 / Treatment of experimental arthritis with M2000 / Pain 28 : 201~222

[book] 이귀녕 / 2003 / 임상병리파일. 3판 / 의학문학사 : 718~1060

[journal] Tracey KJ / 1992 / Tumor necrosis factor in metabolism of disease:hormonal actions vesus local tissue effects / Nouv Rev Fr Hematol 34 : 37~42

[journal] Tracey KJ / 1987 / Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia / Nature 330 : 662~664

[journal] Baker SJ / 1998 / Modulation of life and death by the TNF receptor superfamily / Oncogene 17(25) : 3261~3270

[journal] Firestein GS / 1994 / Protective effect of an adenosine kinase inhibitor in septic shock / J Immunol 152(12) : 5853~5859

[journal] Pennica D / 1984 / Human tumour necrosis factor : precursor structure, expression and homology to lymphotoxin / Nature 312 : 724~729

[journal] Martel-Pelletier J / 2003 / Cyclooxygenase-2 and prostaglandins in articular tissues / Semin Arthritis Rheum 33(3) : 155~167

[journal] Dinarello CA / 1994 / The interleukin-1 family : 10 years of discovery / FASEB J 8(15) : 1314~1325

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6