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@article{ART002216553},
author={고원일 and 이진호 and In-Hyuk Ha and 정화진 and Lee In Hee and 이재웅 and 김은지 and Byeong-gu Gang and Se Hwan Jeon and Yongkyu Cho and 김민정},
title={Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2017},
volume={27},
number={2},
pages={29-38}

TY - JOUR
AU - 고원일
AU - 이진호
AU - In-Hyuk Ha
AU - 정화진
AU - Lee In Hee
AU - 이재웅
AU - 김은지
AU - Byeong-gu Gang
AU - Se Hwan Jeon
AU - Yongkyu Cho
AU - 김민정
TI - Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae
JO - Journal of Korean Medicine Rehabilitation
PY - 2017
VL - 27
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 29
EP - 38
SN - 1229-1854
AB - ObjectivesThe present study aimed to investigate the change in marker compounds, anti-oxidative and anti-inflammatory effects of salt-water processed Cortex Eucommiae.MethodsTo evaluate the influence of processing on anti-oxidant effect of Cortex Eucommiae, changes in total phenol, total flavonoid, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging, and ferric reducing antioxidant power (FRAP) between processed and raw Cortex Eucommiae were assessed. In addition, nitrite assay was conducted to de-termine the influence of processing on anti-inflammatory effect of Cortex Eucommiae. Cell viability was also examined as to elucidate whether processing affects cytotoxicity of Cortex Eucommiae. Finally, high-performance liquid chromatography (HPLC) analysis was conducted to monitor changes in pinoresinol diglucoside amount of processed and raw Cortex Eucommiae.ResultsSalt-water processed Cortex Eucommiae showed higher total phenol and fla-vonoid amount, compared to raw Cortex Eucommiae. Furthermore, anti-oxidative activity of processed Cortex Eucommiae was improved as discovered in DPPH, ABTS, and FRAP assays. Anti-inflammatory effect of Cortex Eucommiae was also enhanced following salt-water processing, as evidenced in nitrite assay. HPLC analysis found that the amount of pinoresinol diglucoside, widely known as the marker compound of Cortex Eucommiae, increases through salt-water processing. All experiments were performed with non-toxic concentration of Cortex Eucommiae; processing did not affect the cytotoxicity of Cortex Eucommiae up to the currently adopted concentration.ConclusionsThe present results support that salt-water processing of Cortex Eucommiae is beneficial in terms of marker compound amount, anti-oxidative, and anti-in-flammatory activities. Additional investigations are needed to standardize the processing method of Cortex Eucommiae. (J Korean Med Rehabil 2017;27(2):29-38)
KW - Cortex Eucommiae;Anti-oxidative;Anti-inflammatory;Salt-water processing
DO -
UR -
ER -

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho and 김민정. (2017). Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae. Journal of Korean Medicine Rehabilitation, 27(2), 29-38.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho and 김민정. 2017, "Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae", Journal of Korean Medicine Rehabilitation, vol.27, no.2 pp.29-38.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho, 김민정 "Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae" Journal of Korean Medicine Rehabilitation 27.2 pp.29-38 (2017) : 29.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho, 김민정. Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae. 2017; 27(2), 29-38.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho and 김민정. "Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae" Journal of Korean Medicine Rehabilitation 27, no.2 (2017) : 29-38.

고원일; 이진호; In-Hyuk Ha; 정화진; Lee In Hee; 이재웅; 김은지; Byeong-gu Gang; Se Hwan Jeon; Yongkyu Cho; 김민정. Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae. Journal of Korean Medicine Rehabilitation, 27(2), 29-38.

고원일; 이진호; In-Hyuk Ha; 정화진; Lee In Hee; 이재웅; 김은지; Byeong-gu Gang; Se Hwan Jeon; Yongkyu Cho; 김민정. Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae. Journal of Korean Medicine Rehabilitation. 2017; 27(2) 29-38.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho, 김민정. Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae. 2017; 27(2), 29-38.

고원일, 이진호, In-Hyuk Ha, 정화진, Lee In Hee, 이재웅, 김은지, Byeong-gu Gang, Se Hwan Jeon, Yongkyu Cho and 김민정. "Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae" Journal of Korean Medicine Rehabilitation 27, no.2 (2017) : 29-38.