Systematic Review on Traditional Chinese Herbal Medicine Treatment for Antibiotic Associated Diarrhea (항생제 연관성 설사의 중의약 치료 효과에 대한 체계적 고찰)

CHANG SEJU (장세주); Myeong-Jong Lee (이명종); Hojun Kim (김호준)

Systematic Review on Traditional Chinese Herbal Medicine Treatment for Antibiotic Associated Diarrhea

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2017, 27(4), pp.85-96
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

CHANG SEJU ¹, Myeong-Jong Lee ¹, Hojun Kim ¹

¹동국대학교

Accredited

ABSTRACT

ObjectivesTo summarize and evaluate the efficacy of traditional Chinese herbal medi-cine (TCHM) treatment for antibiotic associated diarrhea (AAD). MethodsEight electronic databases were searched from their inception to August 2017. Randomized controlled trials (RCTs) assessing the efficacy of TCHM treatment for AAD were included. The risk of bias was assessed using the Cochrane risk of bias assessment tool. Data analysis was performed using RevMan software version 5.3. ResultsSeventeen RCTs involving 1138 patients with AAD were included for qualitative synthesis. TCHM treatment improved total effective rate (TER). However, the results that TER in experimental group was significantly higher than in control group were different be-tween the included studies. TCHM enema treatment improved TER, but not significantly higher than control group. The most frequently used herbal formulas were Gamiwekwan-jeon, Gamiinsampaedoksan, and Samryungbaekchulsan. The most frequently used TCHMs were Atractylodes macrocephala (Bai Zhu), Dioscorea batatas (Shan Yao). Within the studies documenting the adverse events, no serious adverse events associated with TCHM treatment were observed. ConclusionsEvidence of TCHM treatment efficacy for AAD is encouraging, but not con-clusive, because of the low methodological qualities, diversity of TCHM treatment prescriptions. Further well-designed RCTs with rigorous randomization and blinding meth-od are needed to confirm these results. (J Korean Med Rehabil 2017;27(4):85-96)

KEYWORDS

Antibiotic associated diarrhea, Clostridium difficile, Herb, Traditional Chinese medicine

Citation status

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This paper was written with support from the National Research Foundation of Korea.

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6