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DRF and Single Dose Oral Toxicity Study of ChondroT in Rat

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2018, 28(2), pp.61-72
  • DOI : 10.18325/jkmr.2018.28.2.61
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : March 19, 2018
  • Accepted : April 3, 2018
  • Published : April 30, 2018

Young-Ha Lim 1 Ji-Won Jeong 1 Sun-Gil Kim 1 Ji-Hoon Kim 1 Kim Seon Jong 1

1동신대학교 한의과대학 한방재활의학과교실

Accredited

ABSTRACT

Objectives The purpose of this experiment is to evaluate 4 weeks DRF (Dose Rate Finding) and single oral dose toxicity of ChondroT in rats. Methods In 4-week DRF, male and female Sprague-Dawely rats were treated with ChondroT at oral dose of 0, 500, 1000, and 2000 mg/kg. clinical signs, body weight, food consumption, necropsy findings, organ weight, hematological and blood-chemical parameters, and histological findings were monitored for 4 weeks. Also, after single oral administration of ChondroT, mortality, clinical signs, body weight, and necropsy findings were minitored for 2 weeks. Results In 4-week DRF and single dose oral toxicity study of ChondroT in sprague-Dawley rats, ChondroT did not exhibit any toxicity under the study conditions employed. Conclusions The results suggested a no-observed adverse effects level (NOAEL) was over 2,000 mg/kg/day in SD rats after oral administration, this study could be used as basic study of the repeated dose 13-week oral toxicity study of ChondroT. (J Korean Med Rehabil 2018;28(2):61-72)

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