@article{ART002339896},
author={Young-Ha Lim and Ji-Won Jeong and Sun-Gil Kim and Ji-Hoon Kim and Kim Seon Jong},
title={DRF and Single Dose Oral Toxicity Study of ChondroT in Rat},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2018},
volume={28},
number={2},
pages={61-72},
doi={10.18325/jkmr.2018.28.2.61}
TY - JOUR
AU - Young-Ha Lim
AU - Ji-Won Jeong
AU - Sun-Gil Kim
AU - Ji-Hoon Kim
AU - Kim Seon Jong
TI - DRF and Single Dose Oral Toxicity Study of ChondroT in Rat
JO - Journal of Korean Medicine Rehabilitation
PY - 2018
VL - 28
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 61
EP - 72
SN - 1229-1854
AB - Objectives The purpose of this experiment is to evaluate 4 weeks DRF (Dose Rate Finding) and single oral dose toxicity of ChondroT in rats.
Methods In 4-week DRF, male and female Sprague-Dawely rats were treated with ChondroT at oral dose of 0, 500, 1000, and 2000 mg/kg. clinical signs, body weight, food consumption, necropsy findings, organ weight, hematological and blood-chemical parameters, and histological findings were monitored for 4 weeks.
Also, after single oral administration of ChondroT, mortality, clinical signs, body weight, and necropsy findings were minitored for 2 weeks.
Results In 4-week DRF and single dose oral toxicity study of ChondroT in sprague-Dawley rats, ChondroT did not exhibit any toxicity under the study conditions employed.
Conclusions The results suggested a no-observed adverse effects level (NOAEL) was over 2,000 mg/kg/day in SD rats after oral administration, this study could be used as basic study of the repeated dose 13-week oral toxicity study of ChondroT. (J Korean Med Rehabil 2018;28(2):61-72)
KW - ChondroT;Dose Rate Finding;Single Dose Toxicity.
DO - 10.18325/jkmr.2018.28.2.61
ER -
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim and Kim Seon Jong. (2018). DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. Journal of Korean Medicine Rehabilitation, 28(2), 61-72.
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim and Kim Seon Jong. 2018, "DRF and Single Dose Oral Toxicity Study of ChondroT in Rat", Journal of Korean Medicine Rehabilitation, vol.28, no.2 pp.61-72. Available from: doi:10.18325/jkmr.2018.28.2.61
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim, Kim Seon Jong "DRF and Single Dose Oral Toxicity Study of ChondroT in Rat" Journal of Korean Medicine Rehabilitation 28.2 pp.61-72 (2018) : 61.
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim, Kim Seon Jong. DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. 2018; 28(2), 61-72. Available from: doi:10.18325/jkmr.2018.28.2.61
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim and Kim Seon Jong. "DRF and Single Dose Oral Toxicity Study of ChondroT in Rat" Journal of Korean Medicine Rehabilitation 28, no.2 (2018) : 61-72.doi: 10.18325/jkmr.2018.28.2.61
Young-Ha Lim; Ji-Won Jeong; Sun-Gil Kim; Ji-Hoon Kim; Kim Seon Jong. DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. Journal of Korean Medicine Rehabilitation, 28(2), 61-72. doi: 10.18325/jkmr.2018.28.2.61
Young-Ha Lim; Ji-Won Jeong; Sun-Gil Kim; Ji-Hoon Kim; Kim Seon Jong. DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. Journal of Korean Medicine Rehabilitation. 2018; 28(2) 61-72. doi: 10.18325/jkmr.2018.28.2.61
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim, Kim Seon Jong. DRF and Single Dose Oral Toxicity Study of ChondroT in Rat. 2018; 28(2), 61-72. Available from: doi:10.18325/jkmr.2018.28.2.61
Young-Ha Lim, Ji-Won Jeong, Sun-Gil Kim, Ji-Hoon Kim and Kim Seon Jong. "DRF and Single Dose Oral Toxicity Study of ChondroT in Rat" Journal of Korean Medicine Rehabilitation 28, no.2 (2018) : 61-72.doi: 10.18325/jkmr.2018.28.2.61
