@article{ART002434745},
author={Ki Chan Ha and Baek Hyang Im and Hye Mi Kim and Young Mi Kim and Da Young Jeong and Seong Je Hong and Sang Keun Hong and Chang Min Choi},
title={Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2019},
volume={29},
number={1},
pages={75-83},
doi={10.18325/jkmr.2019.29.1.75}
TY - JOUR
AU - Ki Chan Ha
AU - Baek Hyang Im
AU - Hye Mi Kim
AU - Young Mi Kim
AU - Da Young Jeong
AU - Seong Je Hong
AU - Sang Keun Hong
AU - Chang Min Choi
TI - Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract
JO - Journal of Korean Medicine Rehabilitation
PY - 2019
VL - 29
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 75
EP - 83
SN - 1229-1854
AB - Objectives Previous animal studies have shown that mixtures of Cynanchum wilfordii and Phlomis umbrosa extract (IPLUS-CWPU) increases femur length and insulin like growth factor-1 (IGF-1) secretion. IPLUS-CWPU may thus be a promising ingredient in functional foods aimed at growing child's height. The purpose of the study is to investigate the effect of IPLUS-CWPU on height growth in children with short stature.
Methods For this purpose, we recruited 90 children aged 4 to 12 years who had heights ranging from the 5th to 25th percentiles of Korean children's growth curve and randomized to either the IPLUS-CWPU or the placebo group.
Results The IPLUS-CWPU group showed a significant increase in the change of the height growth compared to the placebo group after 20 weeks of administration (p=0.02). The height growth velosity also showed a statistically significant difference in the test group compared to the placebo group at 10 weeks (p=0.04). The IGF-1 levels showed a tendency to increase in the IPLUS-CWPU group (p=0.08). Moreover, the IPLUS-CWPU significantly increased IGF-1/IGFBP-3 ratio (p=0.02). However, there were no significant differences in blood biochemical parameters including growth hormone, bone age, thyroid stimulating hormone, and osteocalcin levels.
Conclusions In conclusion, the data of this trial indicate that IPLUS-CWPU is effective and safe, generally well-tolerated without severe adverse events, in the treatment of children with short stature over a 20 weeks period. (J Korean Med Rehabil 2019;29(1):73-83)
KW - Growth;Short stature;Insulin like growth factor-1 (IGF-1);Growth hormone
DO - 10.18325/jkmr.2019.29.1.75
ER -
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong and Chang Min Choi. (2019). Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract. Journal of Korean Medicine Rehabilitation, 29(1), 75-83.
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong and Chang Min Choi. 2019, "Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract", Journal of Korean Medicine Rehabilitation, vol.29, no.1 pp.75-83. Available from: doi:10.18325/jkmr.2019.29.1.75
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong, Chang Min Choi "Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract" Journal of Korean Medicine Rehabilitation 29.1 pp.75-83 (2019) : 75.
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong, Chang Min Choi. Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract. 2019; 29(1), 75-83. Available from: doi:10.18325/jkmr.2019.29.1.75
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong and Chang Min Choi. "Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract" Journal of Korean Medicine Rehabilitation 29, no.1 (2019) : 75-83.doi: 10.18325/jkmr.2019.29.1.75
Ki Chan Ha; Baek Hyang Im; Hye Mi Kim; Young Mi Kim; Da Young Jeong; Seong Je Hong; Sang Keun Hong; Chang Min Choi. Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract. Journal of Korean Medicine Rehabilitation, 29(1), 75-83. doi: 10.18325/jkmr.2019.29.1.75
Ki Chan Ha; Baek Hyang Im; Hye Mi Kim; Young Mi Kim; Da Young Jeong; Seong Je Hong; Sang Keun Hong; Chang Min Choi. Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract. Journal of Korean Medicine Rehabilitation. 2019; 29(1) 75-83. doi: 10.18325/jkmr.2019.29.1.75
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong, Chang Min Choi. Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract. 2019; 29(1), 75-83. Available from: doi:10.18325/jkmr.2019.29.1.75
Ki Chan Ha, Baek Hyang Im, Hye Mi Kim, Young Mi Kim, Da Young Jeong, Seong Je Hong, Sang Keun Hong and Chang Min Choi. "Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract" Journal of Korean Medicine Rehabilitation 29, no.1 (2019) : 75-83.doi: 10.18325/jkmr.2019.29.1.75
