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Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2019, 29(2), pp.101-113
  • DOI : 10.18325/jkmr.2019.29.2.101
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : March 14, 2019
  • Accepted : April 17, 2019
  • Published : April 30, 2019

Jin Wook Sung 1 Hai Woong Lee 2 Kyung Hwa Kang 3 Kyoung-min Kim 4 Sung Woo Cho 1

1동의대학교 한의과대학 한방재활의학과교실
2동의대학교 한의과대학 예방의학교실
3동의대학교 한의과대학 생리학교실
4동의대학교 한의과대학 내과학교실

Accredited

ABSTRACT

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-1β-treated primary rat chondrocytes. Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-1β (10 ng/mL). Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and PGE2, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-1β-treated primary rat chondrocytes. Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment. (J Korean Med Rehabil 2019;29(2):101-113)

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