@article{ART002462944},
author={Jin Wook Sung and Hai Woong Lee and Kyung Hwa Kang and Kyoung-min Kim and Sung Woo Cho},
title={Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2019},
volume={29},
number={2},
pages={101-113},
doi={10.18325/jkmr.2019.29.2.101}
TY - JOUR
AU - Jin Wook Sung
AU - Hai Woong Lee
AU - Kyung Hwa Kang
AU - Kyoung-min Kim
AU - Sung Woo Cho
TI - Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes
JO - Journal of Korean Medicine Rehabilitation
PY - 2019
VL - 29
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 101
EP - 113
SN - 1229-1854
AB - Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-1β-treated primary rat chondrocytes.
Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-1β (10 ng/mL).
Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and PGE2, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-1β-treated primary rat chondrocytes.
Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment. (J Korean Med Rehabil 2019;29(2):101-113)
KW - Bogol-tang;Osteoarthritis;Monosodium iodoacetate;Nociception
DO - 10.18325/jkmr.2019.29.2.101
ER -
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim and Sung Woo Cho. (2019). Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes. Journal of Korean Medicine Rehabilitation, 29(2), 101-113.
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim and Sung Woo Cho. 2019, "Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes", Journal of Korean Medicine Rehabilitation, vol.29, no.2 pp.101-113. Available from: doi:10.18325/jkmr.2019.29.2.101
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim, Sung Woo Cho "Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes" Journal of Korean Medicine Rehabilitation 29.2 pp.101-113 (2019) : 101.
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim, Sung Woo Cho. Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes. 2019; 29(2), 101-113. Available from: doi:10.18325/jkmr.2019.29.2.101
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim and Sung Woo Cho. "Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes" Journal of Korean Medicine Rehabilitation 29, no.2 (2019) : 101-113.doi: 10.18325/jkmr.2019.29.2.101
Jin Wook Sung; Hai Woong Lee; Kyung Hwa Kang; Kyoung-min Kim; Sung Woo Cho. Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes. Journal of Korean Medicine Rehabilitation, 29(2), 101-113. doi: 10.18325/jkmr.2019.29.2.101
Jin Wook Sung; Hai Woong Lee; Kyung Hwa Kang; Kyoung-min Kim; Sung Woo Cho. Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes. Journal of Korean Medicine Rehabilitation. 2019; 29(2) 101-113. doi: 10.18325/jkmr.2019.29.2.101
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim, Sung Woo Cho. Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes. 2019; 29(2), 101-113. Available from: doi:10.18325/jkmr.2019.29.2.101
Jin Wook Sung, Hai Woong Lee, Kyung Hwa Kang, Kyoung-min Kim and Sung Woo Cho. "Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes" Journal of Korean Medicine Rehabilitation 29, no.2 (2019) : 101-113.doi: 10.18325/jkmr.2019.29.2.101
