@article{ART002517995},
author={Min-Jee Kim and Choi Yu Ra and Na Rae Shin and Myeong-Jong Lee and Hojun Kim},
title={Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2019},
volume={29},
number={4},
pages={15-27},
doi={10.18325/jkmr.2019.29.4.15}
TY - JOUR
AU - Min-Jee Kim
AU - Choi Yu Ra
AU - Na Rae Shin
AU - Myeong-Jong Lee
AU - Hojun Kim
TI - Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice
JO - Journal of Korean Medicine Rehabilitation
PY - 2019
VL - 29
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 15
EP - 27
SN - 1229-1854
AB - Objectives This study was performed to evaluate anti-obesity effects of Crataegus pinnatifida (CP) on high-fat-diet induced obese mice.
Methods The experimental animals were divided into four groups: normal diet (NOR) group, high fat diet (HFD) group, HFD+Xenical (XEN) group, and HFD+CP (CP) group. NOR group was fed a normal diet and the other three groups were fed high fat diet during the experiment. After the first two weeks of diet, XEN group and CP group were administered with XEN or CP for seven weeks, respectively. After that, we measured body weight, liver weight, fat weight, food intake, and serum concentrations of lipids and liver enzymes. Also the liver, intestine, fat tissue was removed to estimate the obesity-related mRNA expressions and the stool sample was collected to analyze the gut microbiota.
Results We found that body weight, fat weight, and triglyceride level were decreased significantly in CP group compared to HFD group. Also CP significantly suppressed gene expressions associated with lipogenesis and inflammation, and increased gene expressions of browning of white adipose tissue and mitochondrial biogenesis. Moreover, it shifted the microbial diversity closer to that of NOR group and increased Firmicutes/Bacteriodetes ratio.
Conclusions These results suggest that CP decrease body weight, fat weight and serum triglyceride. Also it inhibit inflammation and adipogenesis, altering gut microbial diversity and abundance. In conclusion, CP could be used as a therapeutic drug for obesity via gut microbiota modulation. (J Korean Med Rehabil 2019;29(4):15-27)
KW - Crataegus;Microbiota;Obesity
DO - 10.18325/jkmr.2019.29.4.15
ER -
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee and Hojun Kim. (2019). Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice. Journal of Korean Medicine Rehabilitation, 29(4), 15-27.
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee and Hojun Kim. 2019, "Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice", Journal of Korean Medicine Rehabilitation, vol.29, no.4 pp.15-27. Available from: doi:10.18325/jkmr.2019.29.4.15
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee, Hojun Kim "Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice" Journal of Korean Medicine Rehabilitation 29.4 pp.15-27 (2019) : 15.
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee, Hojun Kim. Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice. 2019; 29(4), 15-27. Available from: doi:10.18325/jkmr.2019.29.4.15
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee and Hojun Kim. "Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice" Journal of Korean Medicine Rehabilitation 29, no.4 (2019) : 15-27.doi: 10.18325/jkmr.2019.29.4.15
Min-Jee Kim; Choi Yu Ra; Na Rae Shin; Myeong-Jong Lee; Hojun Kim. Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice. Journal of Korean Medicine Rehabilitation, 29(4), 15-27. doi: 10.18325/jkmr.2019.29.4.15
Min-Jee Kim; Choi Yu Ra; Na Rae Shin; Myeong-Jong Lee; Hojun Kim. Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice. Journal of Korean Medicine Rehabilitation. 2019; 29(4) 15-27. doi: 10.18325/jkmr.2019.29.4.15
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee, Hojun Kim. Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice. 2019; 29(4), 15-27. Available from: doi:10.18325/jkmr.2019.29.4.15
Min-Jee Kim, Choi Yu Ra, Na Rae Shin, Myeong-Jong Lee and Hojun Kim. "Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice" Journal of Korean Medicine Rehabilitation 29, no.4 (2019) : 15-27.doi: 10.18325/jkmr.2019.29.4.15