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The Effect of Herbal Medicine on Rheumatoid Arthritis Animal Model: A systematic Review of Animal Experiment Studies Published in Korea and Overseas

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2020, 30(3), pp.103-116
  • DOI : 10.18325/jkmr.2020.30.3.103
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine
  • Received : June 17, 2020
  • Accepted : July 1, 2020
  • Published : July 31, 2020

Seung-Joon Oh 1 Hyun Ju Ha 1 Gu jihyang 2 Yangchun Park 3 Minseok Oh 4 Inchul Jung 5 LEE EUN JUNG 1

1대전대학교 한의과대학 한방재활의학과교실
2대전대학교 한의과대학 한방재활의학교실
3대전대학교 한의과대학 내과학교실
4대전대학교 한의과대학 한방재활의학과 교실
5대전대학교 한방신경정신과학교실

Accredited

ABSTRACT

Objectives This study was designed to review the effect of herbal medicine on animal model with rheumatoid arthritis. Methods We reviewed studies published both in Korea and overseas, all published after 2008. We investigated 8 databases, 6 Korean databases and 2 of abroad. Searching was conducted through flowchart and 24 studies met our guideline. Datas were extrated and organized as animal model characteristics, experimental period, study design, herbal medicine used as intervention and rheumatoid arthritis indicator. Results 336 articles were primarily selected. After screening, 24 articles were left in the end. All 24 studies showed that the herbal medicine used in the animal experiment was effective on treating rheumatoid arthris, proven by macroscopic, histological, hematological and osteological indicators. Conclusions The result showed that herbal medicine is effective in treating rheumatoid arthritis through various pathways. However, study design and intervention were all different from each other and we could not specify the certain compound, material or substance of efficacy. Further study should be conducted to figure out the effectiveness of herbal medicine on rheumatoid arthritis. (J Korean Med Rehabil 2020;30(3):103-116)

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