Ethical Challenges for Organoid Research and Use: Focusing on Targets of Organoid Research, Donation Procedure, and Future Use (오가노이드의 연구와 이용을 위한 윤리적 과제: 오가노이드 연구의 대상, 기증 절차, 향후 이용을 중심으로)

Choo Jung Wan (추정완); 김상현; NAM Seungmin (남승민); CHOI Eun Kyung (최은경); Hong Suk Young (홍석영); Yoo, SangHo (유상호)

Ethical Challenges for Organoid Research and Use: Focusing on Targets of Organoid Research, Donation Procedure, and Future Use

Korean Journal of Medical Ethics
Abbr : 의료윤리
2023, 26(1), pp.1-16
Publisher : The Korean Society For Medical Ethics
Research Area : Medicine and Pharmacy > General Medicine
Received : November 21, 2022
Accepted : March 31, 2023
Published : March 31, 2023

Choo Jung Wan ¹, 김상현 ², NAM Seungmin ³, CHOI Eun Kyung ⁴, Hong Suk Young ⁵, Yoo, SangHo ⁶

¹춘천교육대학교 윤리교육과
²강원대학교 산학협력단
³이화여자대학교 의과대학
⁴경북대학교 의학교육센터
⁵경상국립대학교 윤리교육과
⁶한양대학교 의과대학 의료인문학교실

Accredited

ABSTRACT

Worldwide, organoids are being used in an increasing range and variety of research contexts, including certain forms of drug testing and transplantation research. In Korea, however, the ethical issues raised by organoid research have received little attention and there are currently no laws or regulations governing this form of research. Accordingly, this study was conducted to identify and examine the ethical challenges for organoid research. The article is structured as follows: Section 2 identifies the organs that can be used in organoid research; Section 3 discusses the precautions for cell donation procedures for organoid research, including the “contents and scope of informed consent,” “cell donor autonomy,” and the “protection of cell donor’s genetic information.” Section 4 examines the ethical challenges of drug testing, patents and commercial uses of organoid research, and the development of organoids for transplantation.

KEYWORDS

organoid, ethics, informd consent, genetic information, human materials, induced pluripotent stem cells

Citation status

* References for papers published after 2023 are currently being built.

[journal] Fatehullah A / 2016 / Organoids as an in vitro model of human development and disease / Nat Cell Biol 18(3) : 246~254

[journal] Nature methods / 2018 / Method of the year 2017 : organoids / Nat Methods 15 : 1~

[journal] Wilson HV / 1907 / A new method by which sponges may be artificially reared / Science 25 : 912~915

[journal] Seok JM / 2021 / 3D printing organoids / J KSME 61(4) : 37~40

[journal] Fukamachi H / 1992 / Proliferation and differentiation of fetal rat intestinal epithelial cells in primary serum-free culture / J Cell Sci 103(Pt. 2) : 511~519

[book] Yahaya BH / 2022 / Organoid technology for disease modelling and personalized treatment / Humana Press : 195~

[journal] Mollaki V / 2021 / Ethical challenges in organoid use / BioTech(Basel) 10(3) : 12~

[journal] Huch M / 2015 / Modeling mouse and human development using organoid cultures / Development 142(18) : 3113~3125

[journal] Kim J / 2020 / Human organoids : model systems for human biology and medicine / Nat Rev Mol Cell Biol 21(10) : 571~584

[journal] Xinaris C / 2019 / Organoids for replacement therapy : expectations, limitations and reality / Curr Opin Organ Transplant 24(5) : 555~561

[journal] Matthews KR / 2020 / National human embryo and embryoid research policies : a survey of 22top research-intensive countries / Regen Med 15(7) : 1905~1917

[journal] de Jongh D / 2022 / Organoids : a systematic review of ethical issues / Stem Cell Res Ther 13(1) : 337~

[journal] Megan P / 2019 / Dynamic consent : an evaluation and reporting framework / J Empir Res Hum Res 15(3) : 175~186

[journal] Budin-Ljøsne I / 2017 / Dynamic consent : a potential solution to some of the challenges of modern biomedical research / BMC Med Ethics 18(1) : 4~

[book] Hisham B / 2022 / Organoid technology for disease modelling and personalized treatment / Humana Press : 201~

[journal] Hyun I / 2020 / Ethical issues related to brain organoid research / Brain Res 1732 : 146653~

[journal] Lensink MA / 2021 / Organoids for personalized treatment of cystic fibrosis : professional perspectives on the ethics and governance of organoid biobanking / J Cyst Fibros 20(3) : 443~451

[journal] Lenk C / 2012 / Is the commercialisation of human tissue and body material forbidden in the countries of the European Union? / J Med Ethics 38(6) : 342~346

[journal] Smadar C / 2016 / Recent patents in organoids / Nat Biotechnol 34 : 619~

[journal] Grady M / 1994 / Politication of commodities : the case of cadaveric organs / J Corp Law 1 1 : 51~68

[journal] 이은영 / 2011 / Ordre public or Morality as Limits of Intellectual Property Rights based on Human Biological Materials / 재산법연구 / 한국재산법학회 28(3) : 63~90

[journal] Tsuchida T / 2020 / Investigation of clinical safety of human iPS cell-derived liver organoid transplantation to infantile patients in porcine model / Cell Transplant 29 : 963689720964384~

[journal] Liu Y / 2021 / Bio-assembling macro-scale, lumenized airway tubes of defined shape via multi-organoid patterning and fusion / Adv Sci 8(9) : 2003332~

[journal] Farahany NA / 2018 / The ethics of experimenting with human brain tissue / Nature 556(7702) : 429~432

[journal] Koplin JJ / 2022 / Response to the ISSCR guidelines on human–animal chimera research / Bioethics 37 : 192~198

[journal] Mansour AA / 2018 / An in vivo model of functional and vascularized human brain organoids / Nat Biotechnol 36(5) : 432~441

[journal] Bitar M / 2020 / Building a human brain for research / Front Mol Neurosci 13 : 22~

[journal] Koplin JJ / 2020 / Emerging moral status issues / Monash Bioeth Rev 38(2) : 95~104

This paper was written with support from the National Research Foundation of Korea.

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Korean Journal of Medical Ethics 2023 KCI Impact Factor : 1.21