A majority of the peoples in Indian cities depend on high fat diet, smoking, ghutka chewing and improper sleep, these all are lifestyle changes, can cause ischemic heart disease. Globally, ischemic heart disease (IHD) is the leading killer. Unani System of medicine not only provides well-based medical cures for diseases, but its holistic approaches as it possess unique principles of diet, lifestyle and particularly therapeutics, to balance and enrich all aspects of physiology and psyche. All diseases are the result of poor management of the six governing (or essential) factors, beyond the ability of physics or Tabiat to maintain and restore homeostasis. In this context, lifestyle diseases can be prevented by conscious changes to the person’s diet, behavior and environment. The holistic approach of Unani medicine is well placed to cover the two main pillars of lifestyle diseases, namely, prevention and treatment. In this paper, we report on the prevalence of CAD in patients with known diagnosis of CAD and try to find out its relationship with different lifestyle changes.