2026, Vol.16, No.

CELLMED 2025 KCI Impact Factor : 0.18

pISSN : 3022-6805 / eISSN : 3022-6791
https://journal.kci.go.kr/cellmed

Objective: Supraorbital pain is a symptom commonly encountered in primary care and can arise from various causes. However, because different disorders may cause pain in similar areas, identifying the exact cause can be difficult. Anatomically, multiple tissue structures are closely packed within the supraorbital region, such that even minor changes in the local environment can readily lead to pain. As the pain worsens, the characteristics of the surrounding tissues may contribute to a cycle of pain development and exacerbation. Various therapeutic approaches have therefore been employed to manage this condition. Case Report: The patient in this case was a Korean woman who complained of severe supraorbital pain accompanied by mild edema. Accordingly, Ortho-Cellular Nutrition Therapy (OCNT), consisting of supplementation with magnesium, calcium, and vitamin D, was administered. Approximately 2 weeks later, the patient reported that the edema had decreased and the supraorbital pain had improved. Conclusion: This case involved an individualized treatment regimen for a single patient with supraorbital pain and therefore has limited generalizability to patients presenting with similar symptoms. However, given the marked improvement in the patient’s symptoms within a short period, this case is considered clinically significant and is therefore reported.

Objective: Vulvovaginal candidiasis (VVC) is an infection caused by Candida species that affects millions of women each year. Vaginal microbiome dysbiosis, pregnancy, hormonal therapy, diabetes mellitus, and immunosuppression are considered contributing factors to its development. More than 90% of uncomplicated VVC cases can be successfully treated with topical agents or a single dose of an oral antifungal agent, whereas recurrent VVC requires long-term maintenance therapy and a systematic treatment strategy. However, even with long-term fluconazole therapy administered once weekly for 6 months, the cure rate at 12 months is only 42.9%, indicating that more than half of women remain uncured. Case Report: The patient in this case was a Korean woman in her 50s who experienced considerable discomfort and stress that interfered with her daily life due to recurrent vulvovaginal candidiasis. Although medications prescribed by an obstetrician-gynecologist provided only temporary symptom relief, the condition continued to recur. Therefore, Ortho-Cellular Nutrition Therapy (OCNT) was initiated. As a result, marked clinical improvement was observed, including relief of her discomfort. The patient was subsequently followed for 2 years, during which no recurrence of vulvovaginal candidiasis was observed. Conclusion: Because this case involved a single patient with a single condition, the applicability of the same OCNT regimen to all patients is limited. However, an appropriately tailored OCNT regimen may be helpful for patients suffering from recurrent vulvovaginal candidiasis, a condition that can be difficult to cure completely.

Objective: Endometrial hyperplasia is characterized by excessive thickening of the endometrial tissue and is considered a precursor lesion of endometrial cancer. Its incidence has been reported as approximately 133 cases per 10,000 women, and it is clinically significant because nearly one-third of patients with endometrial hyperplasia are diagnosed with endometrial cancer. Progestin-based hormonal therapy is commonly used as a noninvasive treatment, whereas invasive approaches include dilation and curettage or hysterectomy. However, these options carry various adverse effects and surgical risks, which often cause patients to avoid or hesitate to undergo treatment. Case Report: The patient was a Korean woman in her 40s who presented with persistent vaginal bleeding for 1 month. Ultrasonographic examination revealed marked endometrial thickening exceeding four times the normal reference level, and she was diagnosed with endometrial hyperplasia. Hormonal therapy to induce withdrawal bleeding was initially administered, but only a modest decrease in endometrial thickness was achieved, insufficient to discontinue treatment. Dilation and curettage was subsequently planned; however, the patient strongly preferred noninvasive conservative management over a surgical or invasive procedure. Thereafter, the patient received Ortho-Cellular Nutrition Therapy (OCNT), and after a period of treatment, significant clinical improvement was observed in both endometrial thickness and vaginal bleeding. Conclusion: As this case concerned a single patient with a single condition, the findings have limited generalizability to other patients receiving the same OCNT regimen. However, an appropriate OCNT regimen may be beneficial for patients who are hesitant to undergo invasive procedures.