KJCKorea
Journal Central

@article{ART002110207},
author={Joseph Oluwatope Adebayo and Olumuyiwa Sunday Adewumi and Simbiat Titilayo Baruwa and Elizabeth Abidemi Balogun and Sylvia Orume Malomo and Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye},
title={Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice},
journal={CELLMED},
issn={3022-6805},
year={2016},
volume={6},
number={2},
pages={12-12}

TY - JOUR
AU - Joseph Oluwatope Adebayo
AU - Olumuyiwa Sunday Adewumi
AU - Simbiat Titilayo Baruwa
AU - Elizabeth Abidemi Balogun
AU - Sylvia Orume Malomo
AU - Lawrence Aderemi Olatunji
AU - Ayodele Olufemi Soladoye
TI - Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice
JO - CELLMED
PY - 2016
VL - 6
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 12
EP - 12
SN - 3022-6805
AB - Cocos nucifera (C. nucifera) oil is indigenously used to treat cardiovascular diseases. However, coconut husk fibre (which is rich in polyphenols) has not been screened for this property. Based on the ethnomedicinal use of polyphenols in treating cardiovascular diseases, this study was carried out to evaluate the effects of polyphenols of C. nucifera husk fibre on selected cardiovascular disease indices in mice. Fifty adult male Swiss albino mice were assigned randomly into five groups (A-E). Mice in groups B, C, D and E were administered 31.25, 62.5, 125, and 250 mg/kg body weight polyphenols of ethyl acetate extract of C. nucifera husk fibre respectively while the control group (A) mice received 5% DMSO for seven days. The mice were sacrificed twenty four hours after the last administration of polyphenols. Heart and plasma lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities and plasma lipid profile were determined. Results revealed significant reduction (*p < 0.05) in plasma levels of total cholesterol and LDL-cholesterol with no significant change (*p > 0.05) in HDL-cholesterol, triglyceride and VLDL levels in the plasma at all doses of polyphenols administered compared to controls. There was significant reduction (*p < 0.05) in the activities of heart AST and LDH while plasma ALT, AST, and ALP activities were not significantly altered (*p > 0.05) at all doses of polyphenols administered compared to controls. These results suggest that the polyphenols of C. nucifera husk fibre possess cardio-protective properties and also indicate their possible use in the treatment of cardiovascular diseases.
KW - coconut;polyphenols;cardiovascular diseases;husk fibre
DO -
UR -
ER -

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye. (2016). Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice. CELLMED, 6(2), 12-12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye. 2016, "Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice", CELLMED, vol.6, no.2 pp.12-12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji, Ayodele Olufemi Soladoye "Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice" CELLMED 6.2 pp.12-12 (2016) : 12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji, Ayodele Olufemi Soladoye. Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice. 2016; 6(2), 12-12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye. "Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice" CELLMED 6, no.2 (2016) : 12-12.

Joseph Oluwatope Adebayo; Olumuyiwa Sunday Adewumi; Simbiat Titilayo Baruwa; Elizabeth Abidemi Balogun; Sylvia Orume Malomo; Lawrence Aderemi Olatunji; Ayodele Olufemi Soladoye. Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice. CELLMED, 6(2), 12-12.

Joseph Oluwatope Adebayo; Olumuyiwa Sunday Adewumi; Simbiat Titilayo Baruwa; Elizabeth Abidemi Balogun; Sylvia Orume Malomo; Lawrence Aderemi Olatunji; Ayodele Olufemi Soladoye. Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice. CELLMED. 2016; 6(2) 12-12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji, Ayodele Olufemi Soladoye. Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice. 2016; 6(2), 12-12.

Joseph Oluwatope Adebayo, Olumuyiwa Sunday Adewumi, Simbiat Titilayo Baruwa, Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Lawrence Aderemi Olatunji and Ayodele Olufemi Soladoye. "Effects of polyphenols of Cocos nucifera husk fibre on selected indices of cardiovascular diseases in mice" CELLMED 6, no.2 (2016) : 12-12.