CELLMED 2023 KCI Impact Factor : 0.03
-
pISSN : 3022-6805 / eISSN : 3022-6791
- https://journal.kci.go.kr/cellmed
KJCKorea
Journal Central
A Review On Nigella sativa (Kalonji) Seeds: A Universal Healer
- CELLMED
- Abbr : CellMed
- 2020, 10(2), pp.11-11
- DOI : 10.5667/CellMed.2020.0011
- Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
- Research Area : Medicine and Pharmacy > General Medicine
- Received : January 9, 2020
- Accepted : March 5, 2020
- Published : May 29, 2020
Anjum Areefa 1, Aslam Mohd 1, Chaudhary Shahid Shah 2
1Dept of Ilmul Advia, Jamia Hamdard
2Dept of Ilmul Saidla, Jamia Hamdard
Candidate
ABSTRACT
Nigella sativa commonly known as Black seed, Black cumin or Kalonji (Family Ranunculaceae) is a widely used for its miraculous healing power. Use of N. sativa seeds and oil has splendid historical past in diverse traditional systems of medicine and food. In Tibb-e-Nabwi (Prophetic Medicine), it is considered as one of the greatest forms of healing medicine. Phytochemically; it contains fixed oil, protein, alkaloids saponin and essential oil. Therapeutic properties of this plant are due to the presence of thymoquinone which is one of major active component and has different beneficial properties. In Unani System of Medicine the diseases are treated with nontoxic herbal drugs. As per Unani classical literature N. sativa perform various pharmacological actions like carminative, anti-inflammatory, analgesic, diuretic, emmenagogue, galactagogue, expectorant etc. Ample of phytochemical, pharmacological and clinical researches has been executed on N. sativa., which may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, etc. This review is an effort to summarize the literature on scientific researches of pharmacognostical characteristics, chemical composition and pharmacological activities of the kalonji seeds
Statistics
-
397 Viewed
-
58 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
Abdelrazek HMA
/ 2018
/ Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats
/ Oxidative Medicine and Cellular Longevity
: 1~10
[journal]
Abdel-Zaher AO
/ 2011
/ Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress
/ Neurotoxicology
32(6)
: 725~733
[journal]
Abel-Salam BK
/ 2012
/ Immunomodulatory effects of black seeds and garlic on alloxan-induced diabetes in albino rat
/ Allergologica et Immunopathological
40(6)
: 336~340
[journal]
Abououf EA
/ 2018
/ Effect Of Nigella sativa Oil On Schistosoma Mansoni Mature Worms In Experimentally Infected Mice
/ Journal of the Egyptian Society of Parasitology
48(1)
: 55~66
[journal]
Abul-Nasr SM
/ 2001
/ Amelioration by Nigella sativa of methotrexate induced toxicity in male albino rats: a biochemical, haematological and histological study
/ Scintia Agriculturae Bohemica
32
: 123~160
[journal]
Aftab A
/ 2019
/ Antifungal Activity of Vegetative Methanolic Extracts of Nigella sativa against Fusarium oxysporum and Macrophomina phaseolina and its Phytochemical Profiling by GC-MS Analysis
/ International journal of agriculture & biology
21
: 569~576
[journal]
Agarwal C
/ 1990
/ Effect of seeds of kalaunji on fertility and sialic acid content of the reproductive organs of male rat
/ Geo Bios
17
: 269~272
[journal]
Ahmad A
/ 2013
/ A review on therapeutic potential of Nigella sativa: A miracle herb
/ Asian Pacific Journal of Tropical Biomedicine
3(5)
: 337~352
[journal]
AI-Jassir SM
/ 1992
/ Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia
/ Food Chemistry
45
: 239~242
[journal]
Akhtar M
/ 2012
/ Ameliorating effects of two extracts of Nigella sativa in middle cerebral artery occluded rat
/ Journal of Pharmacy and Bioallied Science
4(1)
: 70~75
[journal]
Aklaque N
/ 2018
/ Therapeutic & pharmacological potential of Nigella sativa linn. In unani system of medicine: a review
/ World Journal of Pharmaceutical Research
7(12)
: 153~158
[journal]
Al Mofleh IA
/ 2008
/ Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals
/ Saudi Journal of Gastroenterology
14(3)
: 128~134
[journal]
Al-Ali A
/ 2008
/ Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats
/ Journal of Ayub Medical College Abbottabad
20(2)
: 25~27
[journal]
Alemi M
/ 2012
/ Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content
/ AAPS Pharm Sci Tech
[journal]
Al-Ghamdi MS
/ 2001
/ The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa
/ Journal of Ethnopharmacology
76
: 45~48
[journal]
Ali BH
/ 2004
/ The effect of Nigella sativa oil on gentamicin nephrotoxicity in rats
/ American Journal of Chinese Medicine
32(1)
: 49~55
[journal]
Aljabre SH
/ 2005
/ Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone
/ Journal of Ethnopharmacology
101(1-3)
: 116~119
[journal]
Al-Naggar TB
/ 2003
/ Neuropharmacological activity of Nigella sativa L. extracts
/ Journal of Ethnopharmacology
88(1)
: 63~68
[journal]
Al-Othman A M
/ 2006
/ Effect of dietary supplementation of Ellataria cardamun and Nigella sativa on the toxicity of rancid corn oil in rats
/ International Journal of Pharmocology
2(1)
: 60~65
[journal]
Altan MF
/ 2007
/ Combination therapy Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats
/ Acta Histochemica
109(4)
: 304~314
[journal]
Althnaian T
/ 2019
/ Hepatic Gene Expression, Antioxidant Enzymes and Anti-diabetic Effect of Nigella sativa in Diabetic Rats
/ International Journal of Pharmacology
15(2)
: 265~273
[journal]
Andaloussi AB
/ 2008
/ Antidiabetic Activity of Nigella sativa. Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes
/ Pharmaceutical Biology
46(1-2)
: 96~104
[journal]
Andaloussi AB
/ 2011
/ The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle glut4 content
/ Evidence- Based Complementary and Alternative Medicine
2011
: 538671~
[book]
Anonymous
/ 1992
/ II:196-200Anonymous. The Unani Pharmacopoeia Of India
/ Ministry Of Health & Family Welfare Government Of India. YNM
[journal]
Aqel M
/ 1996
/ Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig
/ Journal of Ethnopharmacy
52(1)
: 23~26
[journal]
Arefin Z
/ 2018
/ Oral glucose tolerance test(OGTT)with a polyherbal formulation of Nigella sativa and Brassica alba seeds
/ World Journal of Pharmaceutical Research
7(13)
: 1200~1206
[journal]
Askari G
/ 2019
/ Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta-analysis of clinical trials
/ Phytotherapy Research
33(5)
: 1341~1352
[journal]
Assayed ME
/ 2010
/ Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats
/ Immunopharmacology and Immunotoxicology
32(2)
: 284~296
[journal]
Bakathir HA
/ 2011
/ Detection of the antibacterial effect of Nigella sativa ground seeds with water. African Journal of Traditional
/ Complementary and Alternative Medicine
8(2)
: 159~164
[journal]
Bamosa AO
/ 2010
/ Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
/ Indian Journal of Physiology and Pharmacology
54(4)
: 344~354
[report]
Bodaghi MN
/ 2009
/ The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis
/ Phytotherapy Research
: 1~6
[journal]
Boskabady MH
/ 2007
/ The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients
/ Fundamental and Clinical Pharmacology
21(5)
: 559~566
[journal]
Boskabady MH
/ 2011
/ Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs
/ Journal of Zhejiang University Science B
12(3)
: 201~209
[journal]
Boskabady MH
/ 2008
/ Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s)
/ Indian Journal of Experimental Biology
46(12)
: 805~810
[journal]
Boskabady MH
/ 2010
/ Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
/ Phytomedicine
17(10)
: 707~713
[journal]
Bourgou S
/ 2012
/ Antioxidant, antiinflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (Black Cumin) plant parts
/ Journal of Food Biochemistry
36(5)
: 539~546
[journal]
Butt AS
/ 2019
/ Isolation of thymoquinone from Nigella sativa L. and Thymus vulgaris L., and its anti-proliferative effect on HeLa cancer cell lines
/ Tropical Journal of Pharmaceutical Research
18(1)
: 37~42
[journal]
Butt UJ
/ 2018
/ Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models
/ Toxicology Research
7
: 32~40
[journal]
Canayakin D
/ 2016
/ Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa
/ Pharmaceutical Biology
54(10)
: 2082~2091
[journal]
Chaieb K
/ 2011
/ Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation
/ BMC Complementary and Alternative Medicine
11
: 29~
[journal]
Chehl N
/ 2009
/ Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
/ HPB(Oxford)
11(5)
: 373~381
[journal]
Duncker SC
/ 2012
/ Nigella sativa(Black Cumin)seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors
/ PLoS One
7(6)
: e39841~
[book]
Dymock W
/ 2005
/ Pharmacographia Indica
/ Srishti Book Distributors
: 28~
[journal]
Ebru U
/ 2008
/ Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats
/ Basic and Clinical Pharmacology and Toxicology
103
: 574~580
[journal]
El Mezayen R
/ 2006
/ Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
/ Immunology Letter
106(1)
: 72~81
[journal]
El Shenawy NS
/ 2008
/ The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti schistosomiasis agents in mice
/ Revista do Instituto de Medicina Tropical de Sao Paulo
50(1)
: 29~36
[journal]
El-Abhar HS
/ 2003
/ Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats
/ Journal of Ethnopharmacology
84(2-3)
: 251~258
[journal]
El-Rabey HA
/ 2017
/ The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats
/ Evidence-Based Complementary and Alternative Medicine
[journal]
Ezz HS
/ 2011
/ The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate
/ Neurochemical Research
36(11)
: 2195~2204
[journal]
Fanoudi S
/ 2019
/ Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats
/ Metabolic Brain Disease
[journal]
Fathy M
/ 2018
/ In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa
/ Turkish Journal of Medical Sciences
48
: 178~186
[journal]
Forouzanfar F
/ 2014
/ Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects
/ Iranian Journal of Basic Medical Sciences
17(12)
[journal]
Gendy E
/ 2007
/ Evaluation of the possible antioxidant effects of Soybean and Nigella sativa during experimental hepatocarcinogenesis by nitrosamine precursors
/ Turkish Journal of Biochemistry
32(1)
: 5~11
[book]
Ghani MN
/ Khazainul -advia
/ Aijaz Publication House
: 389~390
[journal]
Ghonime M
/ 2011
/ Evaluation of immunomodulatory effect of three herbal plants growing in Egypt
/ Immunopharmacology and Immunotoxicology
33(1)
: 141~145
[journal]
Gilhotra N
/ 2011
/ Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels
/ Pharmacological Reports
63(3)
: 660~669
[journal]
Gokce A
/ 2011
/ Protective effects of thymoquinone against methotrexate-induced testicular injury
/ Human and Experimental Toxicology
30(8)
: 897~903
[journal]
Hadjzadeh MA
/ 2012
/ Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat
/ Iranian Journal of Kidney Diseases
6(2)
: 99~104
[book]
Hakeem AH
/ Bustanul Muffradat
/ YNM
: 258~
[journal]
Halamova K
/ 2010
/ In vitro antifungal effect of black cumin seed quinones against dairy spoilage yeasts effect of black cumin seed quinones against dairy spoilage yeasts at different acidity levels
/ Journal of Food protection
73(12)
: 2291~2295
[journal]
Halawani E
/ 2009
/ Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Anti
/ Advances in Biological Research
3(5-6)
: 148~152
[journal]
Hannan A
/ 2008
/ Antibacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus
/ Journal of Ayub Medical College Abbottabad
20(3)
: 72~74
[journal]
Harzallah HJ
/ 2012
/ Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2- dimethylhydrazine in erythrocyte during colon post initiation carcinogenesis
/ Oxidative Medicine and Cellular Longevity
: 854065~
[journal]
Hossein BM
/ 2008
/ The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs
/ Experimental Lung Research
34(4)
: 183~194
[journal]
Hosseinia M
/ 2018
/ Administration of Nigella sativa during neonatal and juvenile growth period improved liver function of propylthiouracil-induced hypothyroid rats
/ The Journal of Maternal-Fetal & Neonatal Medicine
: 1476~4954
[journal]
Hosseinian S
/ 2018
/ Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction
/ Phytotherapy Research
: 1~9
[journal]
Hosseinzadeh H
/ 2007
/ Antibacterial Activity of Total Extracts and Essential oil of Nigella sativa L. Seeds in Mice
/ Pharmacolgyonline
2
: 429~435
[journal]
Hosseinzadeh H
/ 2007
/ Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
/ Phytomedicine
14(9)
: 621~627
[journal]
Ikhsan M
/ 2018
/ Nigella sativa as an anti‑inflammatory agent in asthma
/ BMC Research Notes
11
: 744~
[book]
Kabirruddin H.
/ Makhaznul Muffradat
/ YNM
: 460~461
[journal]
Kamal SM
/ 2012
/ Effect of Nigella sativa on the integrity of parotid salivary gland of albino rats and its activity for insulin and glucagon
/ Journal of American Science
8(12)
: 1168~1172
[journal]
Kanter M
/ 2009
/ Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study
/ Journal of Molecular Histology
40(5-6)
: 379~385
[journal]
Kanter M
/ 2009
/ Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations
/ Acta Histochemical
111(5)
: 393~403
[journal]
Kapoor S
/ 2009
/ Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology
/ World Journal of Gastroenterology
7
: 2170~217153
[journal]
Kaur G
/ 2018
/ A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus
/ Journal of Ayurveda and Integrative Medicine
9
: 27~37
[journal]
Keshri G
/ 1995
/ Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats
/ Indian Journal of Physiology and Pharmacology
39(1)
: 59~62
[journal]
Khader M
/ 2009
/ In vitro toxicological properties of thymoquinone
/ Food and Chemical Toxicology
47(1)
: 129~133
[journal]
Khaled AAS
/ 2009
/ Gastroprotective effects of Nigella sativa oil on the formation of stress gastritis in hypothyroidal rats
/ International Journal of Physiology, Pathophysiology and Pharmacology
1
: 143~149
[journal]
Khan MA
/ 2014
/ Muheete- Azam
/ CCRUM
3
: 382~385
[journal]
Khan MAU
/ 2003
/ The In Vivo Antifungal Activity of the Aqueous Extract from Nigella sativa Seeds
/ Phytotherapy Research
17
: 183~186
[journal]
Khan N
/ 2005
/ Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa
/ European journal of Cancer Prevention
14(2)
: 159~168
[journal]
Khosravi AR
/ 2011
/ The potential inhibitory effect of cuminum cyminum, ziziphorac linopodioides and Nigella sativa essential oils on the growth of aspergillus fumigatus and aspergillus flavus
/ Brazilian Journal of Microbiology
42
: 216~224
[journal]
Kirtikar KR
/ 1987
/ Indian Medicinal Plant
/ International Book Distributor
1(2)
: 11~12
[journal]
Kumbhakara DV
/ 2019
/ Assessment of oxidative stress, antioxidant enzyme activity and cellular apoptosis in a plant based system (Nigella sativa L.; black cumin) induced by copper and cadmium sulphide nanomaterials
/ Environmental Nanotechnology, Monitoring & Management
11
[journal]
Lei X
/ 2012
/ Thymoquinone Prevents and ameliorates dextran sulfate sodium-induced colitis in mice
/ Digestive Disease and Science
57(9)
: 2296~2303
[journal]
Lei X
/ 2012
/ Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
/ Biochemical and Biophysical Research Communication
417(2)
: 864~868
[journal]
LorestaniHZ
/ 2018
/ Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice
/ Pesticide Biochemistry and Physiology
148
: 16~21
[journal]
Magdy MA
/ 2012
/ Thymoquinone: Novel gastroprotective mechanisms
/ European Journal of Pharmacology
697(1-3)
: 126~131
[journal]
Mahmoud SS
/ 2012
/ Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin
/ Cell Biochemistry and Biophysics
25(7)
: 1392~1398
[journal]
Mahmoudvand H
/ 2014
/ Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains
/ Journal de MycologieMédicale
482
: 7~
[journal]
Majdalawieh AF
/ 2010
/ Nigella sativa modulates splenocyte proliferation, Th1/T2 cytokine profile, macrophage function and NK anti-tumor activity
/ Journal of Ethnopharmacology
131(2)
: 268~275
[journal]
Mariod AA
/ 2009
/ Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake
/ Food Chemistry
116(1)
: 306~312
[journal]
Mechraoui O
/ 2018
/ Determination of polyphenols content, antioxidant and antibacterial activity of Nigella sativa L. seed phenolic extracts
/ Scientific study & research-Chemistry & chemical engineering, biotechnology, food industry
19(4)
: 411~421
[journal]
Merfort I
/ 1997
/ Flavonol triglycosides from seeds of Nigella sativa
/ Phytochemistry
46(2)
: 359~363
[journal]
Mohamed A
/ 2009
/ Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone-biomed 2009
/ Biomedical Science Instrumentation
45
: 274~279
[journal]
Mohamed AM
/ 2005
/ Nigella sativa seeds against Schistosoma mansoni different stages
/ Memorias do Instituto Oswaldo Cruz
100(2)
: 205~211
[journal]
Morsi NM
/ 2000
/ Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria
/ Acta Microbiologica Polonica
49(1)
: 63~74
[journal]
Mouwakeh A
/ 2019
/ Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus
/ Phytotherapy Research
3
: 1010~1018
[journal]
Mouwakeh A
/ 2018
/ Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes
/ In vivo
32
: 737~743
[journal]
Nagi MN
/ 2011
/ Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
/ Journal of Biochemical and Molecular Toxicology
25
: 135~142
[journal]
Najmi A
/ 2008
/ Effect of Nigella sativa oil on various Clinical and biochemical parameters of metabolic syndrome
/ International Journal of Diabetes in Developing Countries
16
: 85~87
[journal]
Nemmar A
/ 2011
/ Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone
/ British Journal of Pharmacology
164(7)
: 1871~1882
[journal]
Ng WK
/ 2011
/ Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
/ Toxicology In vitro
25(7)
: 1392~1398
[journal]
Nickavara B
/ 2003
/ Chemical Composition of the Fixed and Volatile Oils of Nigella sativa L. from Iran
/ Z. Naturforsch
58
: 629~631
[journal]
Nikakhlagh S
/ 2011
/ Herbal treatment of allergic rhinitis: the use of Nigella sativa
/ American Journal of Otolaryngology
32(5)
: 402~407
[journal]
Onsa RAH
/ 2019
/ Detection of Antibacterial Activity of the Black Cumin (Nigella sativa) Seed Extract against Mycoplasma mycoides subsp mycoides (Mmm)
/ International Journal of Pathogen Research
2(1)
: 1~6
[journal]
Paarakh MP
/ 2010
/ Nigella sativa Linn-A Comprehensive Review
/ Indian journal of natural product and resources
1(4)
: 409~429
[journal]
Pari L
/ 2009
/ Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats
/ Life Science
85(23-26)
: 830~834
[journal]
Peng L
/ 2013
/ Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway
/ Oncology Reports
29(2)
: 571~578
[journal]
Perveen T
/ 2008
/ Long-term administration of Nigella sativa effects nociceotion and improves learning and memory in rats
/ Pakistan Journal of Biochemistry and Molecular Biology
41(3)
: 141~143
[journal]
Perveen T
/ 2009
/ Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats
/ Pakistan Journal of Pharmaceutical Science
22(2)
: 139~144
[journal]
Phulwaria R
/ 2019
/ A review on folklore uses and therapeutic indications of Nigella sativa - a miracle herb
/ World Journal of Pharmaceutical Research
8(1)
: 1369~1379
[journal]
Pichette A
/ 2012
/ Antioxidant, anti-inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts
/ Journal of Food Biochemistry
36(5)
: 539~546
[journal]
Randhawa MA
/ 2015
/ Synthesis, morphology and antifungal activity of nano-particulated amphotericin-B, ketoconazole and thymoquinone against Candida albicans yeasts and Candida biofilm
/ J Environ Sci Health A Tox Hazard Subst Environ Eng
50
: 119~124
[journal]
Rani R
/ 2018
/ Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes
/ Chemico-Biological Interactions
295
: 119~132
[journal]
Ranjbaran H
/ 2018
/ Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds
/ Iran Red Crescent Medical Journal
20(3)
: 62111~
[journal]
Raza M
/ 2008
/ Potentiation of valproate-induced anticonvulsant response by Nigella sativa seed constituents: the role of GABA receptors
/ International Journal of Health Sciences
2(1)
: 15~25
[journal]
Reddy SH
/ 2018
/ Studies on phytochemical screening - GC-MS characterization, antimicrobial and antioxidant assay of black cumin seeds (Nigella sativa) and senna alexandria (Cassia angustifolia) solvent extracts
/ International Journal of Pharmaceutical Sciences and Research
9(2)
: 490~497
[journal]
Rogozhin EA
/ 2011
/ Novel antifungal defensins from Nigella sativa L. seeds
/ Plant Physiology and Biochemistry
49
: 131~137
[book]
Sala AV
/ 1997
/ Indian medicinal plant
/ Orient Longman Ltd
: 139~
[journal]
Salama RH
/ 2011
/ Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model
/ International Journal of Health Science
5(2)
: 126~134
[journal]
Saleem U
/ 2012
/ Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits
/ Pakistan Journal of Pharmaceutical Science
25(4)
: 727~730
[journal]
Salem EM
/ 2010
/ Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia
/ Saudi Journal of Gastroenterology
16(3)
: 207~214
[journal]
Salem ML
/ 2011
/ Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro
/ British Journal of Biomedical Science
68(3)
: 131~137
[journal]
Salim EI
/ 2010
/ Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay
/ Oncology Letters
1(5)
: 913~924
[journal]
Satyavati GV
/ 1987
/ Medicinal Plants of India
/ Indian Council of Medical Research
2
: 337~342
[journal]
Sayed-Ahmed MM
/ 2007
/ Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
/ Clinical and Experimental Pharmacology and Physiology
34(5-6)
: 399~405
[journal]
Shafi G
/ 2008
/ Methanolic extracts of Nigella sativa seed as potent lonogenic inhibitor of PC-3 cells
/ International Journal of Pharmacology
4(6)
: 477~481
[journal]
Shah SB
/ 2018
/ Effect of Nigella sativa seeds extracts on clinically important bacterial and fungal species
/ MOJ Bioequivalence & Bioavailability
5(4)
[journal]
Shuid AN
/ 2012
/ Nigella sativa: A potential antiosteoporotic agent
/ Evidence- Based Complementary and Alternative Medicine
2012
: 696230~
[journal]
Sogut B
/ 2008
/ The effects of diet supplemented with the black Cumin (Nigella sativa L.) upon immune potential and antioxidant marker enzymes and lipid peroxidation in broiler chicks
/ Journal of Animal and Veterinary Advances
7(10)
: 1196~1199
[journal]
Sultana S
/ 2015
/ Nigella sativa: Monograph
/ Journal of Pharmacognosy and Phytochemistry
4(4)
: 103~106
[journal]
Tabassum H
/ 2019
/ Evaluation of the Anticancer Activity of Sprout Extract-Loaded Nanoemulsion of N.sativa against Hepatocellular Carcinoma
/ Journal of Microencapsulation
35(7-8)
: 643~656
[journal]
Tasar N
/ 2012
/ Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats
/ Journal of Research in Pharmacy
16
: 141~149
[journal]
Tayman C
/ 2012
/ Protective effects of Nigella sativa oil in hyperoxia-induced lung injury
/ Archivos de Bronconeumologica
49(1)
: 15~21
[journal]
Tayman C
/ 2012
/ Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis
/ Journal of Investigative Surgery
25(5)
: 286~294
[journal]
Tembhurne SV
/ 2014
/ A review on therapeutic potential of Nigella sativa(kalonji)seeds
/ Journal of Medicinal Plants Research
8(3)
: 167~177
[journal]
Torres MP
/ 2010
/ Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies
/ Molecular Cancer Therapeutics
9(5)
: 1419~1431
[journal]
Ulu R
/ 2012
/ Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury
/ Food and Chemical Toxicology
50(5)
: 1675~1679
[journal]
Umar S
/ 2012
/ Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats
/ Chemico-Biological Interaction
197(1)
: 40~46
[journal]
Ustuna R
/ 2018
/ Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons
/ Neurotoxicology
69
: 68~76
[journal]
Uz E
/ 2008
/ Nigella sativa oil for prevention of chronic cyclosporine nephrotoxicity: an experimental model
/ American Journal of Nephrology
28(3)
: 517~522
[journal]
Wienkotter N
/ 2008
/ The effect of nigellone & thymoquinone on inhibiting trachea contraction and mucociliary clearance
/ Plant Medicine
74(2)
: 105~108
[journal]
Woo CC
/ 2011
/ Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway
/ Biochemical Pharmacology
82(5)
: 464~475
[journal]
Wu ZH
/ 2011
/ Anti-metastasis effect of thymoquinone on human pancreatic cancer
/ Yao Xue Xue Bao
46(8)
: 910~914
[journal]
Yaman I
/ 2010
/ Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats
/ Experimental and Toxicologic Pathology
62(2)
: 183~190
[journal]
Yildiz F
/ 2008
/ Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver
/ World Journal of Gastroenterology
14(33)
: 5204~520952
[journal]
Yildiz F
/ 2010
/ Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys
/ Renal Failure
32(1)
: 126~131
[book]
Younus H.
/ 2018
/ Molecular and Therapeutic actions of Thymoquinone
/ Springer
: 7~17
[journal]
Zafeer MF
/ 2012
/ Cadmium-induced hepatotoxicity and its abrogation by thymoquinone
/ Journal of Biochemical and Molecular Toxicology
26(5)
: 199~205
[journal]
Zaoui A
/ 2002
/ Acute and chronic toxicity of Nigella sativa fixed oil
/ Phytomedicine
9(1)
: 69~74