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Study of adverse drug reactions in pulmonary medicine department of a Tertiary care hospital, Srinagar, Jammu & Kashmir, India

  • CELLMED
  • Abbr : CellMed
  • 2021, 11(2), pp.8-8
  • DOI : 10.5667/CellMed.2021.0008
  • Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
  • Research Area : Medicine and Pharmacy > General Medicine
  • Received : April 2, 2021
  • Accepted : May 12, 2021
  • Published : May 31, 2021

Mudasir Maqbool 1,  Mehrukh Zehravi 2,  Rubeena Maqbool 3,  Irfat Ara 4

1Department of Pharmaceutical Sciences, University of Kashmir
2Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University Alkharj
3Department of Pharmacology, GMC Baramulla
4Regional Research Institute of Unani Medicine

Accredited

ABSTRACT

Background: ADRs (adverse drug reactions) are becoming a vital aspect of patient care and assessment. ADRs account for about 2% of all hospitalizations, according to the incidence rate. Medications with a narrow therapeutic index need ADR control rather than others. ADR research is required to determine the prevalence of ADRs in medical inpatients, estimate the impact of ADRs to hospital admissions, classify the types of ADRs found, identify possibly contributing risk factors, as well as estimate the costs of ADRs in terms of ADR-related excess stay in the hospital. For several years, theophylline has been used to treat asthma and chronic obstructive pulmonary disease (COPD). Theophylline-related adverse events (ADRs) were found to be 4.71 percent of the time, with nausea, anorexia (loss of appetite), and palpitation being the most common. Objective: The main objective of the study was to study adverse drug reactions in pulmonary medicine department of a Tertiary care hospital, Srinagar, Jammu & Kashmir, India. Methodology: For an eight-month period, a prospective, descriptive, cross-sectional study was conducted in the pulmonary medicine department of a Tertiary care hospital in Srinagar, Jammu & Kashmir, India. ADRs that occurred in the ward were closely tracked, and the collected reports were analyzed for demographic profile, type of ADRs, ADR occurrence and drug causing ADR, severity assessment, and ADR management. Results: During the study period, 420 patients' records were obtained from the pulmonary medicine department of a Tertiary care hospital. ADRs were registered in 60 of the patients. The demographics of ADR patients were analyzed, and it was discovered that the prevalence of ADR was highest in the age group of 50-59 years (21 out of 60) and lowest in the age group of <=19 years. The therapeutic drug groups most often involved in ADRs were investigated. The most common culprits among the medications are first-line TB drugs, which account for 21(35%) ADRs, corticosteroids, which account for 9 (15%) ADRs and other drugs used for different indications, such as ipratropium, furosemide, tramadol, and so on, which account for 30 (50%) ADRs. Hepatitis, loss of appetite, nausea, and vertigo were the most widely recorded ADRs in this study. Conclusion: ADRs are more prevalent in the elderly, and first-line TB drugs are more often implicated. The majority of the reactions were moderate. As a result, early identification, assessment, and control of ADRs are critical for reducing patient harm and improving public health.

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