본문 바로가기
  • Home
Basic Search

Enhancement of Erythrosine Photodynamic Therapy against Streptococcus mutans by Chlorhexidine

박종철 1,  Howon Park ORD ID 2,  Siyoung Lee ORD ID 2

1강릉원주대학교 치과대학 소아치과학교실
2강릉원주대학교

Accredited

ABSTRACT

The purpose of this study was to investigate the synergistic effects of erythrosine sensitized with a conventional halogen curing unit and sub-minimal bactericidal concentration(sub-MBC) of chorhexidine on bacterial viability of Streptococcus mutans in planktonic state. Sub-minimal bactericidal concentration of chlorhexidine was added into wells containing bacteria and erythrosine. The range of concentrations tested for chorhexidine was from 0.0000001% to 0.001%. The irradiation of the bacterial suspensions was performed for 15 sec with a conventional halogen curing unit light. In another set of experiment, the effects of 0.001% chlorhexidine were observed by adding chlorhexidine into wells containing the sub-minimal bactericidal concentration of erythrosine. At the concetration of 0.001% chlorhexidine, there were no antibacterial effects in the absence of erythrosine PDT(p < 0.05). At the concentraton of 1 μM erythrosine, there was no photodynamic therapy effect in the absence of chlorhexidine(p < 0.05). But in the presence of sub-minimal bactericidal concentration of erythrosine with light exposure, the addition of 0.001% chlorhexidine increased the bactericidal rate(p < 0.05). A combination of erythrosine PDT with sub-MBC chlorhexidine resulted in a significant reduction in bacterial counts when compared to the case with the absence of chlorhexidine.

Journal Copyright Policy

BY-NC 아이콘

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Statistics

  • 712 Viewed
  • 266 Downloaded

Tools

Issue List

Citation status

* References for papers published after 2025 are currently being built.

Basic Search Advanced Search