Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth

이석우; 전미정; Lee Hyo-Seol (이효설); Je Seon Song (송제선); Heung Kyu Son (손흥규); HYUNG JUN CHOI (최형준); HAN-SUNG JUNG (정한성); Seok Jun Moon (문석준); WONSE PARK (박원서); SEONG OH KIM (김성오)

doi:10.5933/JKAPD.2016.43.2.166

Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth

Journal of the Korean academy of pediatric dentistry
Abbr : J Korean Acad Pediatr Dent
2016, 43(2), pp.166-175
DOI : 10.5933/JKAPD.2016.43.2.166
Publisher : The Korean Academy Of Pediatric Dentistry
Research Area : Medicine and Pharmacy > Dentistry

이석우 ¹, 전미정 ¹, Lee Hyo-Seol ², Je Seon Song ³, Heung Kyu Son ³, HYUNG JUN CHOI ³, HAN-SUNG JUNG ³, Seok Jun Moon ³, WONSE PARK ³, SEONG OH KIM ³

¹연세대학교 치과대학 소아치과학교실
²경희대학교
³연세대학교

Accredited

ABSTRACT

There is no genetic activity information with the functions of dental pulp and periodontal ligament in human. The purpose of this study was to identify the gene-expression profiles of, and the molecular biological differences between periodontal ligament and dental pulp obtained from human permanent teeth. cDNA microarray analysis identified 347 genes with a fourfold or greater difference in expression level between the two tissue types 83 and 264, of which were more plentiful in periodontal ligament and dental pulp, respectively. Periodontal ligament exhibited strong expression of genes related to collagen synthesis (FAP), collagen degradation (MMP3, MMP9, and MMP13), and bone development and remodeling (SSP1, BMP3, ACP5, CTSK, and PTHLH). Pulp exhibited strong expression of genes associated with calcium ions (CALB1, SCIN, and CDH12) and the mineralization and formation of enamel and dentin (SPARC/SPOCK3, PHEX, AMBN, and DSPP). Among these genes, SPP1, SPARC/SPOCK3, AMBN, and DSPP were well known in dental research. However, the other genes are the newly found and it may help to find a good source of regenerative therapy if further study is performed.

KEYWORDS

Gene-Expression, Periodontal Ligament, Dental Pulp, Human Permanent Teeth, Korean

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Journal of the Korean academy of pediatric dentistry 2023 KCI Impact Factor : 0.48

Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth

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* References for papers published after 2023 are currently being built.

Journal of the Korean academy of pediatric dentistry 2023 KCI Impact Factor : 0.48

Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth

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