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@article{ART002349097},
author={Jaewon Hwang and Cho， Eui-Sic and Yang Yeon Mi},
title={Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation},
journal={Journal of the Korean academy of pediatric dentistry},
issn={1226-8496},
year={2018},
volume={45},
number={2},
pages={144-153},
doi={10.5933/JKAPD.2018.45.2.144}

TY - JOUR
AU - Jaewon Hwang
AU - Cho， Eui-Sic
AU - Yang Yeon Mi
TI - Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation
JO - Journal of the Korean academy of pediatric dentistry
PY - 2018
VL - 45
IS - 2
PB - The Korean Academy Of Pediatric Dentistry
SP - 144
EP - 153
SN - 1226-8496
AB - The aim of this study was to understand the roles of Sonic Hedgehog (SHH) signaling during tooth root and periodontium formation. In this study, we generated the dental mesenchyme-specific Smoothened (Smo) activated/ inactivated mice with the activity of Cre recombinase under the control of osteocalcin promoter. In the Smo activated mutant molar sections at the postnatal 28 days, we found extremely thin root dentin and widened pulp chamber. Picrosirius red staining showed loosely arranged fibers in the periodontal space and decreased cellular cementum with some root resorption. Immunohistochemical staining showed less localization of matrix proteins such as Bsp, Dmp1, Pstn, and Ank in the cementum, periodontal ligament, and/or cementoblast. In the Smo inactivated mutant mouse, there was not any remarkable differences in the localization of these matrix proteins compared with the wild type. These findings suggest that adequate suppressing regulation of SHH signaling is required in the development of tooth root and periodontium.
KW - Sonic Hedgehog signaling;Smoothened;Periodontium
DO - 10.5933/JKAPD.2018.45.2.144
ER -

Jaewon Hwang, Cho， Eui-Sic and Yang Yeon Mi. (2018). Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation. Journal of the Korean academy of pediatric dentistry, 45(2), 144-153.

Jaewon Hwang, Cho， Eui-Sic and Yang Yeon Mi. 2018, "Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation", Journal of the Korean academy of pediatric dentistry, vol.45, no.2 pp.144-153. Available from: doi:10.5933/JKAPD.2018.45.2.144

Jaewon Hwang, Cho， Eui-Sic, Yang Yeon Mi "Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation" Journal of the Korean academy of pediatric dentistry 45.2 pp.144-153 (2018) : 144.

Jaewon Hwang, Cho， Eui-Sic, Yang Yeon Mi. Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation. 2018; 45(2), 144-153. Available from: doi:10.5933/JKAPD.2018.45.2.144

Jaewon Hwang, Cho， Eui-Sic and Yang Yeon Mi. "Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation" Journal of the Korean academy of pediatric dentistry 45, no.2 (2018) : 144-153.doi: 10.5933/JKAPD.2018.45.2.144

Jaewon Hwang; Cho， Eui-Sic; Yang Yeon Mi. Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation. Journal of the Korean academy of pediatric dentistry, 45(2), 144-153. doi: 10.5933/JKAPD.2018.45.2.144

Jaewon Hwang; Cho， Eui-Sic; Yang Yeon Mi. Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation. Journal of the Korean academy of pediatric dentistry. 2018; 45(2) 144-153. doi: 10.5933/JKAPD.2018.45.2.144

Jaewon Hwang, Cho， Eui-Sic, Yang Yeon Mi. Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation. 2018; 45(2), 144-153. Available from: doi:10.5933/JKAPD.2018.45.2.144

Jaewon Hwang, Cho， Eui-Sic and Yang Yeon Mi. "Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation" Journal of the Korean academy of pediatric dentistry 45, no.2 (2018) : 144-153.doi: 10.5933/JKAPD.2018.45.2.144