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Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation

  • Journal of the Korean academy of pediatric dentistry
  • Abbr : J Korean Acad Pediatr Dent
  • 2018, 45(2), pp.144-153
  • DOI : 10.5933/JKAPD.2018.45.2.144
  • Publisher : The Korean Academy Of Pediatric Dentistry
  • Research Area : Medicine and Pharmacy > Dentistry
  • Received : August 4, 2017
  • Accepted : September 22, 2017
  • Published : May 31, 2018

Jaewon Hwang 1 Cho, Eui-Sic 2 Yang Yeon Mi 2

1전북대학교 치과대학 구강해부조직학교실 및 구강생체과학연구소
2전북대학교

Accredited

ABSTRACT

The aim of this study was to understand the roles of Sonic Hedgehog (SHH) signaling during tooth root and periodontium formation. In this study, we generated the dental mesenchyme-specific Smoothened (Smo) activated/ inactivated mice with the activity of Cre recombinase under the control of osteocalcin promoter. In the Smo activated mutant molar sections at the postnatal 28 days, we found extremely thin root dentin and widened pulp chamber. Picrosirius red staining showed loosely arranged fibers in the periodontal space and decreased cellular cementum with some root resorption. Immunohistochemical staining showed less localization of matrix proteins such as Bsp, Dmp1, Pstn, and Ank in the cementum, periodontal ligament, and/or cementoblast. In the Smo inactivated mutant mouse, there was not any remarkable differences in the localization of these matrix proteins compared with the wild type. These findings suggest that adequate suppressing regulation of SHH signaling is required in the development of tooth root and periodontium.

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