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@article{ART002467670},
author={Jungeun Gong and Hyunwoo Seo and Lee, Si Young and Howon Park and LEE JU HYUN},
title={Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine},
journal={Journal of the Korean academy of pediatric dentistry},
issn={1226-8496},
year={2019},
volume={46},
number={2},
pages={135-138},
doi={10.5933/JKAPD.2019.46.2.135}

TY - JOUR
AU - Jungeun Gong
AU - Hyunwoo Seo
AU - Lee, Si Young
AU - Howon Park
AU - LEE JU HYUN
TI - Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine
JO - Journal of the Korean academy of pediatric dentistry
PY - 2019
VL - 46
IS - 2
PB - The Korean Academy Of Pediatric Dentistry
SP - 135
EP - 138
SN - 1226-8496
AB - The aim of this study was to investigate the susceptibility of Mutans streptococci in both planktonic and biofilm states to erythrosine. S. mutans was cultured in brain-heart infusion (BHI) broth. Erythrosine was diluted in BHI broth and prepared at a concentration range of 0.02 - 10000 μg/L. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured using the microdilution method. After forming biofilms on 96-well plates, the minimum biofilm inhibitory concentration (MBIC) and minimum biofilm eradication concentration (MBEC) were measured. S. mutans was susceptible to erythrosine in both planktonic and biofilm states. MIC and MBC values were both 19.5 μg/L for the planktonic state, while MBIC and MBEC values were 313 μg/L and 2500 μg/L, respectively, for the biofilm state. Erythrosine (19.5 μg/L) exhibited a bactericidal effect on S. mutans (killing 99.9%) in the planktonic state. For biofilms, erythrosine inhibited biofilm growth and eradicated 99.9% of biofilm bacteria at higher concentrations than MIC and MBC. These MBIC and MBEC concentrations are much lower than known noxious doses, and the MIC, MBC, and MBIC values were even lower than clinical concentrations.
KW - Erythrosine;Mutans streptococci;Biofilm;Susceptibility
DO - 10.5933/JKAPD.2019.46.2.135
ER -

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park and LEE JU HYUN. (2019). Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine. Journal of the Korean academy of pediatric dentistry, 46(2), 135-138.

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park and LEE JU HYUN. 2019, "Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine", Journal of the Korean academy of pediatric dentistry, vol.46, no.2 pp.135-138. Available from: doi:10.5933/JKAPD.2019.46.2.135

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park, LEE JU HYUN "Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine" Journal of the Korean academy of pediatric dentistry 46.2 pp.135-138 (2019) : 135.

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park, LEE JU HYUN. Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine. 2019; 46(2), 135-138. Available from: doi:10.5933/JKAPD.2019.46.2.135

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park and LEE JU HYUN. "Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine" Journal of the Korean academy of pediatric dentistry 46, no.2 (2019) : 135-138.doi: 10.5933/JKAPD.2019.46.2.135

Jungeun Gong; Hyunwoo Seo; Lee, Si Young; Howon Park; LEE JU HYUN. Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine. Journal of the Korean academy of pediatric dentistry, 46(2), 135-138. doi: 10.5933/JKAPD.2019.46.2.135

Jungeun Gong; Hyunwoo Seo; Lee, Si Young; Howon Park; LEE JU HYUN. Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine. Journal of the Korean academy of pediatric dentistry. 2019; 46(2) 135-138. doi: 10.5933/JKAPD.2019.46.2.135

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park, LEE JU HYUN. Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine. 2019; 46(2), 135-138. Available from: doi:10.5933/JKAPD.2019.46.2.135

Jungeun Gong, Hyunwoo Seo, Lee, Si Young, Howon Park and LEE JU HYUN. "Susceptibility of Mutans streptococci in the Planktonic and Biofilm State to Erythrosine" Journal of the Korean academy of pediatric dentistry 46, no.2 (2019) : 135-138.doi: 10.5933/JKAPD.2019.46.2.135