Characteristics of Intravenous Midazolam Sedation with Nitrous Oxide in Pediatric Dental Treatment (소아환자에서 midazolam 정주 및 아산화질소 흡입진정법 하 치과치료의 특성)

Hyuntae Kim (김현태); Ji-Soo Song (송지수); Hong-Keun Hyun (현홍근); Young-Jae Kim (김영재); Jung-Wook Kim (김정욱); Ki-Taeg Jang (장기택); Sang-Hoon Lee (이상훈); Teo Jeon Shin (신터전)

doi:10.5933/JKAPD.2020.47.1.53

Characteristics of Intravenous Midazolam Sedation with Nitrous Oxide in Pediatric Dental Treatment

Journal of the Korean academy of pediatric dentistry
Abbr : J Korean Acad Pediatr Dent
2020, 47(1), pp.53~61
DOI : 10.5933/JKAPD.2020.47.1.53
Publisher : The Korean Academy Of Pediatric Dentistry
Research Area : Medicine and Pharmacy > Dentistry
Received : July 21, 2019
Accepted : September 19, 2019
Published : February 29, 2020

Hyuntae Kim ¹, Ji-Soo Song ¹, Hong-Keun Hyun ², Young-Jae Kim ², Jung-Wook Kim ², Ki-Taeg Jang ², Sang-Hoon Lee ², Teo Jeon Shin ²

¹서울대학교 치의학대학원 소아치과학교실
²서울대학교

Accredited

ABSTRACT

Midazolam is a short-acting benzodiazepine that is widely used in pediatric dental sedation. However, its clinical effectiveness as an intravenous sedative agent in children has not been widely documented. A retrospective study was conducted to evaluate the efficacy and safety of intravenous midazolam and nitrous oxide inhalation sedation in pediatric dental treatment. The subjects were 115 patients (118 cases) who received dental treatment under intravenous midazolam and nitrous oxide inhalation sedation. Demographic factors, general health status, sedation time, midazolam and nitrous oxide dosage, and success rate of sedation were evaluated from electronic medical records. Behavioral management was the main reason of choosing sedation. Mean duration of sedation was 56.7 minutes for surgical treatment, and 74.4 minutes for restorative treatment. The initial dosage of intravenous midazolam was 0.051 ± 0.019 mg/kg. In 34 cases (28.8%), additional midazolam of 0.036 ± 0.057 mg/kg was delivered during the treatment. The concentration of nitrous oxide was maintained between 40% and 50%. The success rate of sedation was 99% (n = 117). In 1 case, laryngospasm occurred and the patient was reversed with benzodiazepine antagonist, flumazenil. Intravenous midazolam sedation with nitrous oxide was shown to be clinically effective for the dental treatment in children, if administered by trained personnel and patients are carefully selected in accordance with guidelines.

KEYWORDS

Intravenous sedation, Midazolam, Nitrous oxide, Behavior management

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Journal of the Korean academy of pediatric dentistry 2024 KCI Impact Factor : 0.36

Characteristics of Intravenous Midazolam Sedation with Nitrous Oxide in Pediatric Dental Treatment

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* References for papers published after 2024 are currently being built.

Journal of the Korean academy of pediatric dentistry 2024 KCI Impact Factor : 0.36

Characteristics of Intravenous Midazolam Sedation with Nitrous Oxide in Pediatric Dental Treatment

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