2018, Vol.28, No.1

Effects of Jeopgolsan (JGS) Extract on Fracture Healing

Han-Gil Lee , Minseok Oh | 2018, 28(1) | pp.1~17 | number of Cited : 6

Objectives The purpose of this study was to evaluate the effect of Jeopgolsan (JGS) extract on anti-oxidant, anti-inflammatory activities in RAW 264.7 cells and on factors related with fracture healing in skull fractured rat. Methods Experimental animals were divided into four groups: normal group without any treatment (Normal), contral group were treated orally with distilled water (Control), Experimental group were treated orally with JGS at a concentration of 200 mg/kg/day (JGS 200) and Experimental group were treated orally with JGS at a concentration of 200 mg/kg/day (JGS 400). Rats in each group except the normal group were induced fractures in the skull. ＜In vitro＞ The 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity were measured to evaluate antioxidant activity. The production of nitric oxide (NO), interleukin- 1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the RAW 264.7 cells were measured to evaluate anti-inflammatory activity. ＜In vivo＞ The production of osteocalcin calcitonin, carboxy-terminal telepeptides of type II collagen (CTX II), transforming growth factor-β (TGF-β), bone morphogenetic protein-2 (BMP-2), Insulin and alkaline phosphatase (ALP) in serum of rats were measured to evaluate the effects of fracture healing at 0, 2, 4, and 6th week. X-rays were taken every 3 week from 0 to 6th week to evaluate fracture healing effect. Results 1. No cytotoxicity was observed. 2. DPPH and ABTS radical scavenging activity were increased in a concentration dependent manner, indicating anti-oxidant effect. 3. NO, IL-1β, IL-6, and TNF-α were not significantly changed, indicating no anti-inflammatory effect. 4. Osteocalcin, Calcitonin, TGF-β and ALP were significantly increased in the experimental groups. 5. CTX II, insulin were significantly decreased in the expermental groups. 6. Radiologic examination showed that union of fracture was promoted. Conclusions From above results, JGS showed significant results in factors related with fracture healing and radiologic examination. Threfore, JGS is expected to be effective in the treatment of fracture. (J Korean Med Rehabil 2018;28(1):1-17)

Effects of Jinmu-tang on the Osteoarthritis by MIA in Rats

Doo-Hwa Yang , Chang-Hoon Woo , Hee Duk An | 2018, 28(1) | pp.19~31 | number of Cited : 4

Objectives The object of this study was to investigate the antioxidative and antiinflammatory effects of Jinmu-tang extract (JMT) on the Monosodium iodoacetate (MIA)-induced rat osteoarthritis. Methods To investigate the antioxidant capacities of JMT, we measured the total polyphenol and flavonoid, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-Azino-bis(3-ethyl- benzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. To evaluate the antioxidative and antiinflammatory effects of JMT, the rats were divided into 5 groups (n=8). Normal group was not induced by MIA and treated at all (N), control group was induced by MIA and not treated at all (Con), positive control group was induced by MIA and orally administered indomethacin 5 mg/kg (Indo) and experimental groups were induced by MIA and orally administered JMT 100 mg/kg (JMT100) and JMT 200 mg/kg (JMT200) for 4 weeks. The changes of anti-type II collagen antibody in serum, heme oxygenase-1 (HO-1), phosphorylated inhibitor of κBα (p-IκBα), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α) in knee joint tissue and histopathological observation (Hematoxylin & Eosin and Safranin-O stain) were measured. Results Total polyphenol and flavonoid levels of JMT were 26.90±0.33 mg/g and 6.02±0.34 mg/g. IC50 of L-ascorbic acid and JMT of DPPH radical scavenging activity were 1.35±0.07 μg/ml and 52.95±0.97 μg/ml. IC50 of L-ascorbic acid and JMT of ABTS radical scavenging activity were 3.18±0.02 μg/ml and 91.49±1.74 μg/ml. In serum, the anti-type II collagen antibody levels of JMT100 and JMT200 groups were decreased significantly. In knee joint tissue, the HO-1 level of JMT200 was increased significantly. The p-IκBα and TNF-α levels of JMT200 were decreased significantly. The COX-2 and iNOS levels of JMT groups were decreased significantly. In histopathological observation, in comparison with Con, synovial tissue, cartilage and proteoglycan of JMT100 and JMT200 were well preserved. Conclusions According to the results, It is considered that JMT has antioxidant and antiinflammatory effects for MIA-induced rat osteoarthritis, so it could be applied to osteoarthritis treatment. (J Korean Med Rehabil 2018;28(1):19-31)

A Review of the Pain and Function Assessment Instruments for Shoulder Disease Patients in Korean Medicine Clinical Studies Published in South Korea

Geon-Yeong Lee , Jo Hee Geun , SUL JAE UK and 1 other persons | 2018, 28(1) | pp.33~51 | number of Cited : 4

Reviewing Research of Eastern-Western Integrative Medicine Studies in Korea

Kuk-In Han , Seon-Ho Shin , Gwang-Mook Lim and 2 other persons | 2018, 28(1) | pp.53~60 | number of Cited : 10

Proposal of Checklists for Patient Safety in Miniscalpel Acupuncture Treatment of Cervical and Lumbar Spine: Pilot Trial

Jo Hee Geun , Min-Yeong Song , Sang-Hoon Yoon and 4 other persons | 2018, 28(1) | pp.61~72 | number of Cited : 3

A Web-based Survey for Assessment of Korean Medical Treatment Clinical Practice Patterns for Temporomandibular Disorders

Chang-Eun Kim , Ho-Jeong Do , Hyun-Seop Song and 12 other persons | 2018, 28(1) | pp.73~84 | number of Cited : 4

Comparison Study about Surface Mapping of Motor Points in Biceps Brachii Muscle Using Surface EMG and Electric Probe

Jaewon Park , Dongho Keum | 2018, 28(1) | pp.85~96 | number of Cited : 1

Objectives This study was performed to compare the electrical methods of motor points mapping using surface EMG and electric probe (Pointer Excel II). Methods 32 healthy adults (male 16, female 16) were selected. and classified into two groups; surface EMG group, electric probe (Pointer Excel II) group. In surface EMG group, motor points were searched by recoding the compound muscle potentials. In electric probe (Pointer Excel II) group, motor points were searched by scanning the skin with Pointer Excel II at low level stimulation. The locations of the motor points were expressed as X and Y values in relation to the reference line. The horizontal reference line was set as elbow crease and the vertical reference line was set as the line connecting coracoid process to the center of the horizontal reference line. The data was analyzed by ‘Independent T-test’ and ‘equivalence test’. Results 1. The motor points of short head and long head of biceps brachii muscle were located at about 2/3 length of the vertical reference line from coracoid process and about 1/5∼1/4 length of the half of the horizontal reference line from the vertical reference line in both group. 2. The motor points of the short head were located more distally and close to the vertical reference line (p＜0.001). 3. In surface EMG group, the motor points of the long head were located more laterally in the female than male. And the motor points of the long head were located more distally in the left side than right side (p＜0.05). In electric probe (Pointer Excel II) group, similar tendency was observed but there was no statistically significant difference (p＞0.05). 4. As a result of the equivalence test between surface EMG group and electric probe (Pointer Excel II) group, the confidence intervals of the difference were within the equivalence limit. Therefore, the locations of the motor points searched by two ways are equa l (p＞0.05, equivalence interval=3%). Conclusions The results indicate that electric probe (Pointer Excel II) can be used to search the motor points instead of surface EMG. This might improve the clinical efficiency when using the motor points to treat muscle dysfunction. (J Korean Med Rehabil 2018;28(1):85-96)

Proposal of East-West Integrative Medicine Manual for Rehabilitation after Knee Surgery

Min-Yeong Song , Jo Hee Geun , SUL JAE UK and 1 other persons | 2018, 28(1) | pp.97~107 | number of Cited : 4

Proposal of East-West Integrative Medicine Manual for Rehabilitation after Shoulder Surgery

Min-Yeong Song , Jo Hee Geun , SUL JAE UK and 1 other persons | 2018, 28(1) | pp.109~120 | number of Cited : 5

Trends of Government Funded Research for Kampo Medicine in Japan and It’s Implication

Chang-woon Jeung , Chang-Hyuk Choi , Jo Hee Geun and 2 other persons | 2018, 28(1) | pp.121~131 | number of Cited : 1

Analysis of the Medical Market Share of Traditional East Asian Medicine (TEAM) in Taiwan Using National Health Insurance Research Database (NHIRD)

Chang-woon Jeung , Chang-Hyuk Choi , Hee-Geun Jo and 1 other persons | 2018, 28(1) | pp.133~144 | number of Cited : 3

Post-stroke Spasticity Treated by Miniscalpel-Acupuncture: Three Case Report

Sang-Hoon Yoon , Jo Hee Geun , Min-Yeong Song | 2018, 28(1) | pp.145~152 | number of Cited : 3

A Case Report of Korean Medicine Treatment on Back Pain of a Parkinson’s Disease Patient

Doo-Ri Kim , Joo-Won Kim , Won-Hyung Ryu and 4 other persons | 2018, 28(1) | pp.153~160 | number of Cited : 4

Peripheral Post-traumatic Cervical Dystonia Treated by Miniscalpel-Acupuncture: A Case Report

Sang-Hoon Yoon , Jo Hee Geun , Min Gu Kwon and 1 other persons | 2018, 28(1) | pp.161~166 | number of Cited : 4

Postoperative Rehabilitation of Korean Medicine for Ankle Fractures Treated by Open Reduction with Internal Fixation: 2 Case Reports with 5 Months Follow-Up

Min Gu Kwon , Jo Hee Geun , Hye-Rin Park and 1 other persons | 2018, 28(1) | pp.167~173 | number of Cited : 3

Korean Medicine Therapy to Ruptured Anterior Cruciate Ligament with Meniscal Tears: Report of 4 Cases

Gi-Eon Lee , Da-Young Byun , Si-Hoon Han and 2 other persons | 2018, 28(1) | pp.175~184 | number of Cited : 6

A Case Report of Superior Labrum from Anterior to Posterior Tear Patient Treated with Shinbaro Pharmacopuncture and Motion Style Acupuncture Treatment (MSAT)

Ok Jun Kwon , Gil-Hwan Kim , Yeong-Guk Ju and 5 other persons | 2018, 28(1) | pp.185~193 | number of Cited : 5

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2018, Vol.28, No.1