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Effects of Prunellae Herba on Proteoglycan Degradation in Collagenase-induced Rat Osteoarthritis Model

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2007, 17(1), pp.17-26
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

류헌식 1,  Kim， Soon-joong 1,  Seo,Il-bok 1,  Jeong， Su-hyeon 1

1세명대학교

Candidate

ABSTRACT

Effects of Prunellae Herba on Proteoglycan Degradation in Collagenase-induced Rat Osteoarthritis Model Heon-Sik Ryu, O.M.D., Su-Hyeon Jeong, O.M.D., Sun-Jung Kim, O.M.D., Il-Bok Seo* Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Se-Myung UniversityDept. of Anatomy, College of Oriental Medicine, Se-Myung University* Objectives : This study was to investigate the effects of Prunellae Herba on Proteoglycan(PG) degradation by measuring body weight, Glycosaminoglycan(GAG), Interleukin-1β(IL-1β) in synovial fluid, and PG content of articular cartilage of femur in collagenase-induced arthritis in rats. Methods : Arthritis was induced by injection of collagenase(0.1 ml) into knee joint of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken normal saline for 15 days and treated group was taken extracts of Prunellae Herba for same duration. Normal group(n=8), non-arthritic group, was injected with normal saline and was taken normal saline for 15 days. Body weight was measured at 0, 10, 15 days after injection. GAG, IL-1β in synovial fluid were measured with ELISA kit at 15 days after injection. PG content of articular cartilage of femur, represented by safranine O staining, was measured at 15 days after injection. Histopathological study on the articular cartilage of knee joint was investigated at 15 days after injection. Results : Body weight of treated group was not significantly increased, PG of treated group was significantly increased, and GAG was significantly decreased compared with control group. But IL-1β was not significantly decreased. Conclusions : On the basis of these results, we concluded that Prunellae Herba has inhibiting effects on the Proteoglycan degradation in collagenase-induced rat osteoarthritis model.

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