Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Effect of Nardostachytis Rhizoma on Induction of Differentiation in HL-60 Cells
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2007, 17(1), pp.61-74
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
윤상학 1, Seung-ryong Yeom 1, SONG YUNG SUN 1, Young Dal Kwon 1, 박종하 1, 김경수 1, 오원교 1
1원광대학교
Candidate
ABSTRACT
Effect of Nardostachytis Rhizoma on Induction of
Differentiation in HL-60 Cells
Sang-Hak Yun, O.M.D., Jong-Ha Park, O.M.D., Kyeong-Su Kim, O.M.D., Won-Kyo Oh, O.M.D., Seung-Ryong Yeom, O.M.D., Young-Dal Kwon, O.M.D., Yung-Sun Song, O.M.D.
Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University
Objectives :
To investigate PKC/MAPKs signaling pathways on the human promyelocytic leukemia HL-60 cell differentiation induced by Nardostachytis Rhizoma (N. Rhizoma).
Methods :
Differentiation of HL-60 cells was determined through expression of CD11b and CD14 surface antigens using flow cytometry and nitroblue tetrazolium (NBT) assay. PKC activity was measured by using a PKC Kinase Activity Assay kit (Non-Radioactive). Activation of ERK and protein levels of PKC isoforms were determined by Western blot analysis.
Results :
Activation of extracellular signal-regulated kinase (ERK) increased time-dependently in differentiation of HL-60 cells induced by N. Rhizoma. Inhibitor of ERK (PD98059) significantly reduced NBT reduction activity induced by N. Rhizoma in HL-60 cells. In addition, N. Rhizoma increased protein level of PKC α, PKC βI and PKC βII isoforms, but the protein level of PKC γ was constant. PKC inhibitors (GF 109203X, Chelerythrine and H-7) inhibited HL-60 cell differentiation and the ERK activation induced by N. Rhizoma.
Conclusions :
N. Rhizoma induces granulocytic differentiation via a PKC/ERK signaling pathway in HL-60 cells.
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