Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
-
pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Effect of Nardostachytis Rhizoma on Induction of Differentiation in HL-60 Cells
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2007, 17(1), pp.61-74
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
윤상학 1, Seung-ryong Yeom 1, SONG YUNG SUN 1, Young Dal Kwon 1, 박종하 1, 김경수 1, 오원교 1
1원광대학교
Candidate
ABSTRACT
Effect of Nardostachytis Rhizoma on Induction of
Differentiation in HL-60 Cells
Sang-Hak Yun, O.M.D., Jong-Ha Park, O.M.D., Kyeong-Su Kim, O.M.D., Won-Kyo Oh, O.M.D., Seung-Ryong Yeom, O.M.D., Young-Dal Kwon, O.M.D., Yung-Sun Song, O.M.D.
Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University
Objectives :
To investigate PKC/MAPKs signaling pathways on the human promyelocytic leukemia HL-60 cell differentiation induced by Nardostachytis Rhizoma (N. Rhizoma).
Methods :
Differentiation of HL-60 cells was determined through expression of CD11b and CD14 surface antigens using flow cytometry and nitroblue tetrazolium (NBT) assay. PKC activity was measured by using a PKC Kinase Activity Assay kit (Non-Radioactive). Activation of ERK and protein levels of PKC isoforms were determined by Western blot analysis.
Results :
Activation of extracellular signal-regulated kinase (ERK) increased time-dependently in differentiation of HL-60 cells induced by N. Rhizoma. Inhibitor of ERK (PD98059) significantly reduced NBT reduction activity induced by N. Rhizoma in HL-60 cells. In addition, N. Rhizoma increased protein level of PKC α, PKC βI and PKC βII isoforms, but the protein level of PKC γ was constant. PKC inhibitors (GF 109203X, Chelerythrine and H-7) inhibited HL-60 cell differentiation and the ERK activation induced by N. Rhizoma.
Conclusions :
N. Rhizoma induces granulocytic differentiation via a PKC/ERK signaling pathway in HL-60 cells.
Statistics
-
230 Viewed
-
0 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
/ 2000
/ Pharmacopoeia of the People's Republic of China. Vol. I
/ Beijing: Chemical Industry Press
: 65~
[journal]
/ 2002
/ Modern Chinese Materia Medica
/ Beijing: Chemical Industry Press
: 252~
[journal]
/ 2000
/ Novel Guaiane Endoperoxides, Nardoguaianone A-D, from Nardostachys chinensis Roots and their Antinociceptive and Antimalarial Activities
56
: 7678~7683
[journal]
/ 1993;41
/ Cytotoxic sesquiterpenes from Nardostachys chinensis
: 1183~4
[journal]
/ 2003
/ Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells
145
: 177~183
[journal]
/ 1979;76
/ Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents
: 1293~7
[journal]
/ 1979;76
/ Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester
: 2779~83
[journal]
/ 1978;75
/ Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds
: 2458~62
[journal]
/ 1997
/ Promotion of HL-60 cell differentiation by 1,25-dihydroxyvitamin D3 regulation of protein kinase C levels and activity
54
: 909~915
[journal]
/ 1994;269
/ Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells
: 872~8
[journal]
/ 2005
/ Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone
511
: 89~97
[journal]
/ 2003
/ Differential involvement of protein kinase C in human promyelocytic leukemia cell differentiation enhanced by artemisinin
482
: 67~76
[journal]
/ 2000
/ Serine/ threonine protein kinases and apoptosis
256
: 34~41
[journal]
/ 2001
/ Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
22
: 153~183
[journal]
/ 1999
/ MAP kinase pathways
71
: 479~500
[journal]
/ 1995
/ Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
270
: 1326~1331
[journal]
/ 2000
/ Signal transduction by the JNK group of MAP kinases
103
: 239~252
[journal]
/ 1998
/ Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest
58
: 3163~3172
[journal]
/ 1999
/ Retinoic acid selectively activates the ERK2 but not JNK/SAPK or p38 MAP kinases when inducing myeloid differentiation
35
: 527~532
[journal]
/ 2001
/ Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells
80
: 471~482
[journal]
/ 2000
/ Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells
258
: 425~437
[journal]
/ 2001
/ Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells
82
: 68~77
[journal]
/ 1997
/ Protein kinase C: a worthwhile target for anticancer drugs?
8
: 26~33
[journal]
/ 1992;8
/ The expression and possible roles of protein kinase C in haematopoietic cells
: 201~11
[journal]
/ 1996
/ Regulation of protein kinase C: a tale of lipids and proteins
49
: 231~261
[journal]
/ 1991;51
/ Expression of three major protein kinase C isozymes in various types of human leukemic cells Cancer Res
: 4271~8
[journal]
/ 1991;5
/ co-operates with retinoic acid on the induction of functional N-formyl-methionyl-phenylalanine receptors in HL-60 cells
: 26~31
[journal]
/ 1997
/ 1,25-Dihydroxyvitamin D3 induced activation and subsequent nuclear translocation of MAPK is upstream regulated by PKC in HL-60 cells. Biochem Biophys Res Commun
241
: 419~426
[journal]
/ 1980;77
/ Induction of differentiation of the human promyelocytic leukemia cell line
by reti(ic acid)
: 2936~60 40
[journal]
/ 1978;75
/ Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds
: 2458~62
[journal]
/ 1979;76
/ Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester
: 2779~83
[journal]
/ 1983;117
/ 25-dihydroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells but not into granulocytes
into mo(cyte-macrophages)
: 86~60 92
[journal]
/ 2003
/ Mechanisms involved in the induced differentiation of leukemia cells
100
: 257~290
[journal]
/ 2005
/ Terpenoids from the roots and rhizomes of Nardostachys chinensis
68
: 1131~1133
[journal]
/ 2002
/ Guaiane- and aristolane-type sesquiterpenoids of Nardostachys chinensis roots
59
: 845~849
[journal]
/ 2003
/ Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells
93
: 122~125
[journal]
/ 2002
/ Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines
16
: 683~692
[journal]
/ 1998
/ Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest
58
: 3163~3172
[journal]
/ 2001
/ Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid
276
: 4012~4019
[journal]
/ 2000
/ Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D3-induced differentiation of human leukemia HL60 cells
258
: 425~437
[journal]
/ 2000
/ Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway
67
: 869~875
[journal]
/ 2003
/ Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor
65
: 1611~1622
[journal]
/ 2001
/ Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C
61
: 1487~1495
[journal]
/ 1996
/ Protein kinase C isozymes and substrates
8
: 168~173
[journal]
/ 1998
/ The molecular heterogeneity of protein kinase C and its implications for cellular regulation
334
: 661~665
[journal]
/ 1994;269
/ Activation of β- isozyme of protein kinase C is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes
: 4327~31
[journal]
/ 1990;50
/ Decreased expression of type II protein kinase C in HL-60 variant cells resistant to induction of cell differentiation by phorbol diester
: 621~6
[journal]
/ 1994;269
/ Protein kinase C-β is required for macrophage differentiation of human HL-60 leukemia cells
: 23230~5
[journal]
/ 1992;3
/ Protein kinase C beta gene expression is associated with susceptibility of human promyelocytic leukemia cells to phorbol ester-induced differentiation
: 739~45
[journal]
/ 1993;4
/ Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase
: 657~63
[journal]
/ 1997
/ Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants
8
: 221~230
[journal]
/ 1994;83
/ All-trans retinoic acid reverses phorbol ester resistance in a human myeloid leukemia cell line
: 490~6