@article{ART001053393},
author={김현수 and Dongseok Heo and Minseok Oh and Yoon il ji},
title={A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2007},
volume={17},
number={2},
pages={39-53}
TY - JOUR
AU - 김현수
AU - Dongseok Heo
AU - Minseok Oh
AU - Yoon il ji
TI - A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis
JO - Journal of Korean Medicine Rehabilitation
PY - 2007
VL - 17
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 39
EP - 53
SN - 1229-1854
AB - Objectives :
Gwanjul-bang(Guanjie-fang)-3 (GJB-3) is a prescription used clinically to treat rheumatoid arthritis. The purpose of this study is to investigate the immunity responses of GJB-3 to the human fibroblast-like synoviocytes isolated from patients with rheumatoid arthritis.
Methods :
Experimental groups were divided into 6 groups ; The hFLS were stimulated with hrTNF-α(100 ng/ml) and hrIL-1β(10 U/ml). Afterwards, They were treated with medium (CT), methotrexate (10㎍/ml, MTX) and GJB-3 (1, 10, 100㎍/ml) for 6 hours. The cells were harvested following the further incubation with [3H]-thymidine reagent for 4 hours. The WT group was cultured without cytokine stimulation.
Results :
1. The proliferation of hFLSs was significantly reduced in 100㎍/ml dose.
2. The mRNA expression of TNF-α and the production of ROS was dose-dependently reduced in hFLS.
3. The mRNA expression of IL-1β, IL-6, IL-8, ICAM-1, NOS-Ⅱ, MMP-3 were reduced in high concentration.
4. The production of NO was significantly reduced in over 10㎍/ml dose.
5. The mRNA expression of TIMP-1 was dose-dependently increased.
Conclusions :
We found out that GJB-3 is considered to be effective in treating rheumatoid arthritis.
KW - Gwanjul-bang(Guanjie-fang)-3 (GJB-3);hFLSs;Rheumatoid arthritis
DO -
UR -
ER -
김현수, Dongseok Heo, Minseok Oh and Yoon il ji. (2007). A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis. Journal of Korean Medicine Rehabilitation, 17(2), 39-53.
김현수, Dongseok Heo, Minseok Oh and Yoon il ji. 2007, "A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis", Journal of Korean Medicine Rehabilitation, vol.17, no.2 pp.39-53.
김현수, Dongseok Heo, Minseok Oh, Yoon il ji "A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis" Journal of Korean Medicine Rehabilitation 17.2 pp.39-53 (2007) : 39.
김현수, Dongseok Heo, Minseok Oh, Yoon il ji. A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis. 2007; 17(2), 39-53.
김현수, Dongseok Heo, Minseok Oh and Yoon il ji. "A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis" Journal of Korean Medicine Rehabilitation 17, no.2 (2007) : 39-53.
김현수; Dongseok Heo; Minseok Oh; Yoon il ji. A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis. Journal of Korean Medicine Rehabilitation, 17(2), 39-53.
김현수; Dongseok Heo; Minseok Oh; Yoon il ji. A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis. Journal of Korean Medicine Rehabilitation. 2007; 17(2) 39-53.
김현수, Dongseok Heo, Minseok Oh, Yoon il ji. A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis. 2007; 17(2), 39-53.
김현수, Dongseok Heo, Minseok Oh and Yoon il ji. "A Study on the Effect of Gwanjul-bang(Guanjie-fang)-3 in Rheumatoid Arthritis" Journal of Korean Medicine Rehabilitation 17, no.2 (2007) : 39-53.
