Effect of Amygdalin on the Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Crushed Sciatic Nerve Injury in Rats (행인에서 추출한 Amygdalin이 좌골신경 단열로 신경이 손상된 쥐의 기능회복 및 중심회백질의 c-Fos 발현에 미치는 영향)

김영욱; SONG YUN KYUNG (송윤경); Lim Hyung Ho (임형호)

Effect of Amygdalin on the Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Crushed Sciatic Nerve Injury in Rats

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2006, 16(4), pp.37-47
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

김영욱 ¹, SONG YUN KYUNG ¹, Lim Hyung Ho ¹

¹경원대학교

Candidate

ABSTRACT

배경 : 말초 신경 손상은 임상에서 자주 발생하는 질환으로 통증 조절계에 영향을 주어 만성 통증을 유발하고, 연관 부위에 운동 기능 장애를 남기는 질환이다. 목적 : 본 연구의 목적은 좌골 신경 손상으로 유발된 만성 통증과 운동기능 저하에 있어 Amygdalin의 통증 감소 및 기능 회복 효과에 대하여 알아보고자 함이다. 방법 : 좌골 신경에 손상을 입힌 쥐에 행인에서 추출된 Amygdalin을 복강내에 투입하여, 보행 분석과 면역조직화학을 활용한 vlPAG내 c-Fos 발현을 측정하여 통증 감소 및 기능 회복 정도를 판별하였다. 결과 : 복강 내에 행인에서 추출된 Amygdalin을 투입을 한 쥐는 보행분석과 면역조직화학을 활용한 vlPAG내 c-Fos 발현 정도에서 통증 감소 및 기능 회복에 있어 유의성 있는 변화를 보였다. 결론 : Amygdalin은 말초 신경 손상에 의한 질환에 있어 통증 조절 및 운동 기능 회복에 뚜렷한 효과가 있는 것으로 생각된다. Key words : Amygdalin, Sciatic function index (SFI), c-Fos Expression, Ventrolateral periaqueductal gray (vlPAG)

KEYWORDS

Amygdalin, Sciatic function index (SFI), c-Fos Expression, Ventrolateral periaqueductal gray (vlPAG)

Citation status

* References for papers published after 2023 are currently being built.

[journal] / 1988 / :A Peripheral Mononeuropathy in Rats That Produces Disorders of Pain Sensation Like Those Seen in Man 33(1) : 87~107

[journal] / 2003 / Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus 73(24) : 3139~3147

[journal] / 2003 / Analgesia and c-Fos expression in the periaqueductal gray induced by electro-acupuncture at the Zusanli point in rats 973(2) : 196~204

[journal] / 2004 / Administration of MK-801 decreases c-Fos expression in the trigeminal sensory nuclear complex but increases it in the midbrain during experimental movement of rat molars 1021(2) : 183~191

[journal] / 2000 / Video analysis of standing-an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerve 102(2) : 109~116

[journal] / 1982 / :An index of the functional condition of rat sciatic nerves based on measurements made from walking tracks 77(3) : 634~43

[journal] / 1997 / Functional evaluation of complete sciatic and posterior tibial nerve lesions in the rat 100(5) : 1362~

[journal] / 2005 / Armeniacae semen extract suppresses lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells 28(3) : 449~454

[journal] / 2005 / Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells 11(33) : 5156~5161

[journal] / 1986 / Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function Beneficial effects of melanocortins : 2 237~3 46

[journal] / 2004 / Descending control of persistent pain: inhibitory or facilitatory? 46(3) : 295~309

[journal] / 2004 / Novel pharmacologic options in the treatment of neuropathic pain 9( ) : 1~11

[journal] / 2004 / Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice / 370 : 130~134

[journal] / 1994 / The analgesic mechanism of processed Aconiti tuber the involvement of descending inhibitory system iso(t) : 83~94

[journal] / 1999 / Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord 79(3) : 295~301

[journal] / 2003 / Modulation of Chelidonii herba on glycine-activated and glutamate-activated ion currents in rat periaqueductal gray neurons 337 : 93~101

[journal] / 2004 / Modulation of Corydalis tuber on glycine-induced ion current in acutely dissociated rat periaqueductal gray neurons 27(8) : 1207~1211

[journal] / 1978 / Special report on Laetrile Results of the National Cancer Institute's retrospective Laetrile analysis : 549~52

[journal] / 2003 / Toe out angle: a functional index for the evaluation of sciatic nerve recovery in the rat model 183(2) : 695~699

[journal] / 2004 / Sciatic nerve regeneration in mice and rats recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome 1027 : 67~72

[journal] / 2002 / Mechanisms of neuropathic pain and their importance in Fabry disease 91(439) : 34~37

[journal] / 1992 / :Evidence for the involvement of serotonin in the antinociception induced by electrical or chemical stimulation of the mesencephalic tectum 50(12) : 77~83

[journal] / Change in the Expression of c-fos in the Rat Brain Following Sciatic Nerve Ligation

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