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@article{ART001224275},
author={이정우 and SONG YUNG SUN and Young Dal Kwon and Seung-ryong Yeom},
title={Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={1},
pages={65-74}

TY - JOUR
AU - 이정우
AU - SONG YUNG SUN
AU - Young Dal Kwon
AU - Seung-ryong Yeom
TI - Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 65
EP - 74
SN - 1229-1854
AB - Objectives : This experimental study was designed to investigate the effects of Lumbricus extract (LE) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LE. Methods : The changes of rCBF were observed by Laser-Doppler flowmetry (LDF) and the changes of MABP were recorded by a data acquisition system assembled with MacLab and Macintosh. Results : LE significantly increased rCBF in a high dosage(10.0 mg/kg, i.p), but MABP was somewhat increased as compared with baseline. This result suggests that LE significantly increased rCBF by dilating pial arterial diameter. Increase of LE-induced rCBF was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase, but was not significantly inhibited by pretreatment with methylene blue (10 μg/kg, i.p.), an inhibitor of guanylate cyclase. Conclusions : LE increased rCBF by dilating pial arterial diameter, and the action of this response was mediated by cyclooxygenase
KW - Lumbricus;Regional cerebral blood flow(rCBF);Mean arterial blood pressure(MABP);Cyclooxygenase
DO -
UR -
ER -

이정우, SONG YUNG SUN, Young Dal Kwon and Seung-ryong Yeom. (2008). Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats. Journal of Korean Medicine Rehabilitation, 18(1), 65-74.

이정우, SONG YUNG SUN, Young Dal Kwon and Seung-ryong Yeom. 2008, "Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats", Journal of Korean Medicine Rehabilitation, vol.18, no.1 pp.65-74.

이정우, SONG YUNG SUN, Young Dal Kwon, Seung-ryong Yeom "Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats" Journal of Korean Medicine Rehabilitation 18.1 pp.65-74 (2008) : 65.

이정우, SONG YUNG SUN, Young Dal Kwon, Seung-ryong Yeom. Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats. 2008; 18(1), 65-74.

이정우, SONG YUNG SUN, Young Dal Kwon and Seung-ryong Yeom. "Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats" Journal of Korean Medicine Rehabilitation 18, no.1 (2008) : 65-74.

이정우; SONG YUNG SUN; Young Dal Kwon; Seung-ryong Yeom. Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats. Journal of Korean Medicine Rehabilitation, 18(1), 65-74.

이정우; SONG YUNG SUN; Young Dal Kwon; Seung-ryong Yeom. Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats. Journal of Korean Medicine Rehabilitation. 2008; 18(1) 65-74.

이정우, SONG YUNG SUN, Young Dal Kwon, Seung-ryong Yeom. Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats. 2008; 18(1), 65-74.

이정우, SONG YUNG SUN, Young Dal Kwon and Seung-ryong Yeom. "Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats" Journal of Korean Medicine Rehabilitation 18, no.1 (2008) : 65-74.