2008, Vol.18, No.1

Curcumin's Effect on ICAM-1 VCAM-1 Expression in Human Umbilical Vein Endothelial Cells

김경수 , Young Dal Kwon , SONG YUNG SUN and 2 other persons | 2008, 18(1) | pp.1~13 | number of Cited : 1

Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats

김용문 , Kim， Soon-joong , Seo,Il-bok and 1 other persons | 2008, 18(1) | pp.15~32 | number of Cited : 6

Objectives : This study was to investigate the effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Monosodium iodoacetate induced arthritic rats were divided into control and treated group. Control group was taken distilled water for 20 days. Treated group was taken extracts of Gamisoyeoum-tang(Jiaweixiaoyan-tang) by orally for same duration. Normal group was injected with normal saline and was taken distilled water. Body weights were measured at 0, 5, 10, 15, 20 days after injection. At the end of experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Contents of TNF-α, IL-1β, IL-6 in synovial fluids and proteoglycan contents of articular cartilages were analysed. COX-2 and iNOS immunohistochemical examination on the knee joints were performed. Results : 1. Body weights of the treated group were significantly increased compared with control group at 20 days after injection. 2. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control group. 3. PG contents in articular cartilages of the treated group were significantly increased compared with control group. 4. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control group. 5. IL-1β contents in synovial fluids of the treated group were significantly decreased compared with control group. 6. Positive reactions of COX-2 in chondrocytes and synovial membranes of the treated group were decreased compared with the control group. Conclusions : On the basis of these results, we concluded that Gamisoyeoum-tang(Jiaweixiaoyan-tang) has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it's effects were related with reduced secretion of IL-1β and COX-2 from osteoarthritic chondrocytes and synovial membranes.

Effects of Samhwang-tang(Sanhuang-tang) on Obese Rats Induced by High Fat Diet, MSG and Ovariectomy

민홍규 , Sohn YoungJoo , Jung Hyuk-Sang and 3 other persons | 2008, 18(1) | pp.33~46 | number of Cited : 2

Effects of Eucommiae Cortex on Myofiber Type Transition and MyoD Expression in Hind Limb Muscle Atrophy of Rats

Yoon, Duk-Young , Jongsoo Lee , Seong-ha Park | 2008, 18(1) | pp.47~63 | number of Cited : 4

Objectives : Eucommiae cortex is reported that it helps bone and skeletal muscle stronger. In case of bone, many report is presented, but reports related to skeletal muscle are rarely existed. So in order to investigate effects of Eucommiae cortex on the skeletal muscle atrophy following stroke, cerebral infarct was induced by the middle cerebral artery occlusion (MCAO) in the rats. Methods : In order to induce MCAO rats, nylon suture was advanced and then blocked middle cerebral artery(MCA). Water extract of Eucommiae cortex was treated for 15 days, once a day orally, after the MCAO. Effects were evaluated with muscle weights, muscle fiber type composition, cross-sectioned area of muscle fibers in soleus and gastrocnemius of the unaffected and affected hind limbs. And MyoD protein expression in gastrocnemius was demonstrated with immunohistochemistry and western blotting. Results : In the affected hind limb of the MCAO rats, muscle weight loss of gastrocnemius and tibialis anterior muscles were attenuated by Eucommiae cortex treatment. In soleus muscle of the affected hind limb of the MCAO rats, increase of type-I fibers and decrease of type-II fibers were induced by Eucommiae cortex treatment. In soleus muscle of the affected hind limb of the MCAO rats, decrease of cross-sectioned areas of type-I fibers was attenuated by Eucommiae cortex treatment. In gastrocnemius muscle of the affected hind limb of the MCAO rats, increase of type-I fibers and decrease of type-II fibers were induced by Eucommiae cortex treatment. In gastrocnemius muscle of the affected hind limb of the MCAO rats, decreases of cross-sectioned areas of type-I and type-II fibers were attenuated by Eucommiae cortex treatment. In gastrocnemius muscle of the affected hind limb of the MCAO rats, MyoD positive cells were increased by Eucommiae cortex treatment. In gastrocnemius muscles both of the affected and unaffected hind limb of the MCAO rats, MyoD expressions were increased by Eucommiae cortex treatment. Conclusions : These results suggest that Eucommiae cortex has a protective effect against muscle atrophy, through the inhibition of the muscle cell apoptosis, following the central nervous system demage.

Effects of Lumbricus on the Change of Cerebral Hemodynamics in Rats

이정우 , SONG YUNG SUN , Young Dal Kwon and 1 other persons | 2008, 18(1) | pp.65~74 | number of Cited : 1

Effects of GCP Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats

이승헌 , Kim， Soon-joong , Seo,Il-bok and 1 other persons | 2008, 18(1) | pp.75~94 | number of Cited : 8

Objectives : This study was to investigate the effects of GCP treatment on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Arthritis was induced by injection of Monosodium Iodoacetate(0.5mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken distilled water for 20 days. Treated group was taken extracts of GCP by oraly for same duration. Normal group(n=8) was injected with normal saline and was taken distilled water for 20 days. Body weight was measured at 0, 5, 10, 15, 20 days after injection. Macroscopic examination and histopathological study on articular cartilage of knee joint were operated at 20 days after injection. Proteoglycan(PG) content of articular cartilages of knee joint was represented by safranine O staining, was measured at 20 days after injection. Tumor necrosis factor-α, Interleukin-1β, Interleukin-6 in synovial fluid were measured with ELISA kit at 20 days after injection. Immunohistochemical staining of COX-2, iNOS in knee joints were observed at 20 days after injection. Results : 1. Body weight of the treated group increased compare with control group at 20 days after injection. 2. Macroscopically, degree of osteoarthritis in the treated group were evaluated compared with the control group. 3. PG content in articular cartilage of the treated group was significantly increased compared with the control group. 4. Histopathologically, osteoarthritic scores of the treated group was significantly decreased compared with the control group. 5. TNF-α content in synovial fluid of the treated group was decreased compared with the control group. 6. IL-1β content in synovial fluid of the treated group was significantly decreased compared with the control group. 7. Positive reaction of COX-2 in chondrocytes and synovial membrane of the treated group was faint compared with the control group. Conclusions : On the basis of these results, we concluded that GCP has inhibiting effects on the IL-1β and COX-2 secretion of chondrocytes and synovial membrane in Monosodium Iodoacetate-Induced osteoarthritis model of rats.

Effects of Dimethoxycurcumin, a Synthetic Curcumin Analogue,on Nitric Oxide Production in RAW264.7 Macrophage

박성혁 , Young Dal Kwon , SONG YUNG SUN and 1 other persons | 2008, 18(1) | pp.95~110 | number of Cited : 0

The Effect of Double Application of Functional Electrical Stimulation in Patients with Dysphgia after Stroke

Chungyong Yang , Chong Bok Hee , Shin, Byung Cheul | 2008, 18(1) | pp.111~123 | number of Cited : 3

The Influences of Progressive Muscle Relaxation on Meridian-Electromyograph, Autonomic Nervous System and Stress in Healthy People

남기봉 , Chung, Seok Hee , Sungsoo Kim | 2008, 18(1) | pp.125~140 | number of Cited : 7

A Comparative Study on the Balance of Musculoskelectal System between Long-Term Employed Male Taxi Drivers and General People - through Moire Topography

임상훈 , Kim， Soon-joong , 박동수 and 2 other persons | 2008, 18(1) | pp.141~151 | number of Cited : 5

A Clinical Study on the Effect of Korean Medical Treatments for Patients with Lumbar Disc Herniation

윤유석 , Jongsoo Lee , SHIN HYUN DAE and 2 other persons | 2008, 18(1) | pp.153~161 | number of Cited : 9

The Effects of Intervention on Thoracic Vertebral Region's Du mai(督脈) and Jia ji xue(夾脊穴) for Shoulder Pain ; 4 Clinical Case Report

InSeon lee , 김봉현 , 김민규 | 2008, 18(1) | pp.163~172 | number of Cited : 3

Effect of Bong Chuna Manual Treatment Combined with Oriental Medical Treatment on Posterior Inferior Ilium Deviation ; 3 Cases Report

오원교 , Shin, Byung Cheul | 2008, 18(1) | pp.173~185 | number of Cited : 7

KJCKorea
Journal Central

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

2008, Vol.18, No.1