@article{ART001224031},
author={김용문 and Kim, Soon-joong and Seo,Il-bok and Jeong, Su-hyeon},
title={Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={1},
pages={15-32}
TY - JOUR
AU - 김용문
AU - Kim, Soon-joong
AU - Seo,Il-bok
AU - Jeong, Su-hyeon
TI - Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 15
EP - 32
SN - 1229-1854
AB - Objectives :
This study was to investigate the effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the monosodium iodoacetate-induced osteoarthritis in rats.
Methods :
Monosodium iodoacetate induced arthritic rats were divided into control and treated group. Control group was taken distilled water for 20 days. Treated group was taken extracts of Gamisoyeoum-tang(Jiaweixiaoyan-tang) by orally for same duration. Normal group was injected with normal saline and was taken distilled water. Body weights were measured at 0, 5, 10, 15, 20 days after injection. At the end of experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Contents of TNF-α, IL-1β, IL-6 in synovial fluids and proteoglycan contents of articular cartilages were analysed. COX-2 and iNOS immunohistochemical examination on the knee joints were performed.
Results :
1. Body weights of the treated group were significantly increased compared with control group at 20 days after injection.
2. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control group.
3. PG contents in articular cartilages of the treated group were significantly increased compared with control group.
4. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control group.
5. IL-1β contents in synovial fluids of the treated group were significantly decreased compared with control group.
6. Positive reactions of COX-2 in chondrocytes and synovial membranes of the treated group were decreased compared with the control group.
Conclusions :
On the basis of these results, we concluded that Gamisoyeoum-tang(Jiaweixiaoyan-tang) has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it's effects were related with reduced secretion of IL-1β and COX-2 from osteoarthritic chondrocytes and synovial membranes.
KW - Monosodium iodoacetate;Osteoarthritis;Proteoglycan;TNF-α;IL-1β;COX-2;Gamisoyeoum-tang(Jiaweixiaoyan-tang)
DO -
UR -
ER -
김용문, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. (2008). Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation, 18(1), 15-32.
김용문, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. 2008, "Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats", Journal of Korean Medicine Rehabilitation, vol.18, no.1 pp.15-32.
김용문, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon "Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18.1 pp.15-32 (2008) : 15.
김용문, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon. Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. 2008; 18(1), 15-32.
김용문, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. "Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18, no.1 (2008) : 15-32.
김용문; Kim, Soon-joong; Seo,Il-bok; Jeong, Su-hyeon. Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation, 18(1), 15-32.
김용문; Kim, Soon-joong; Seo,Il-bok; Jeong, Su-hyeon. Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation. 2008; 18(1) 15-32.
김용문, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon. Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. 2008; 18(1), 15-32.
김용문, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. "Effects of Gamisoyeoum-tang(Jiaweixiaoyan-tang) on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18, no.1 (2008) : 15-32.