Curcumin&#039;s Effect on ICAM-1 VCAM-1 Expression in Human Umbilical Vein Endothelial Cells (혈관내피세포에서 curcumin이 ICAM-1 및 VCAM-1발현에 미치는 효과)

김경수; Young Dal Kwon (권영달); SONG YUNG SUN (송용선); 나철; Shin, Byung Cheul (신병철)

Curcumin's Effect on ICAM-1 VCAM-1 Expression in Human Umbilical Vein Endothelial Cells

Journal of Korean Medicine Rehabilitation
Abbr : JKMR
2008, 18(1), pp.1-13
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

김경수 ¹, Young Dal Kwon ¹, SONG YUNG SUN ¹, 나철 ¹, Shin, Byung Cheul ²

¹원광대학교
²부산대학교

Accredited

ABSTRACT

목 적 : 동맥경화 유발에 있어서 중요한 역할을 수행하는 부착분자는 혈관내피세포가 염증성 물질에 자극 받아서 생성된다. 본 연구는 항염증성 curcumin이 혈관내피세포 부착분자 발현에 미치는 효과를 조사하였다. 방 법 : 혈관내피세포는 HUVEC을 사용하였고, 염증성 물질 TNF-α로 자극하였다. 결 과 : Curcumin은 부착분자 VCAM-1 및 ICAM-1 발현을 억제시켜, 혈관내피세포에 백혈구가 부착되는 것을 억제하였다. Curcumin은 ICAM-1 및 VCAM-1 promoter 활성을 억제하였고, 또한 억제 kB의 인산화를 차단하였다. Curcumin은 NF-kB p65의 핵내 이동을 차단하였고, 세포내 ROS 양을 감소시켰고, JNK 및 p38 인산화를 억제시켰다. 그러나 curcumin은 TNF 수용체 I 및 II에 어떠한 영향도 미치지 못했다. 결 론 : Curcumin이 NF-kB 비활성화 및 p38과 JNK의 기능저하를 매개로 VCAM-1 및 ICAM-1의 발현을 억제할 수 있음을 알 수 있었다.

KEYWORDS

Curcumin, VCAM-1, ICAM-1

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Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

Curcumin's Effect on ICAM-1 VCAM-1 Expression in Human Umbilical Vein Endothelial Cells

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* References for papers published after 2023 are currently being built.

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

Curcumin's Effect on ICAM-1 VCAM-1 Expression in Human Umbilical Vein Endothelial Cells

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KEYWORDS

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