@article{ART001232866},
author={김효영 and Dongseok Heo},
title={The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={2},
pages={81-96}
TY - JOUR
AU - 김효영
AU - Dongseok Heo
TI - The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 81
EP - 96
SN - 1229-1854
AB - Objectives :
This study was performed to investigate inhibitory effects of Gamipalmul-tang(jiaweibawu-tang) on the hematological and histological changes of obese mice.
Methods :
C57BL/6 mice were divided into four groups (normal group, high fat diet with normal saline, high fat diet with reductil, high fat diet with Gamipalmul-tang(jiaweibawu-tang)) and fed for 8 weeks. Body weight change, final increase of body weight, ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, cell viability by cytotoxicity, the expression of β3AR in 3T3-L1 cell, the expression of leptin, β3AR and serotonin in adipocyte tissue and size of adipocyte were observed in 8 weeks.
Results :
1. In 3T3-L1 cell. the expression of β3AR was increased significantly.
2. The final increase of body weight in obese-mouse were decreased significantly.
3. The level of AST, ALT were decreased significantly.
4. The level of LDL-cholesterol was decreased significantly and HDL-cholesterol was increased significantly.
5. The levels of triglyceride was decreased and leptin and glucose were decreased significantly.
6. In adipocyte tissue, the expression of β3AR were increased significantly.
7 In adipocyte tissue, the expression of leptin and serotonin were decreased significantly.
8. The size of Adipocyte was decreased.
Conclusions :
On the basis of these results, we concluded that Gamipalmul-tang(jiaweibawu-tang) has inhibitory effects in rat.
KW - Gamipalmul-tang(jiaweibawu-tang);Obesity;Body wight;Aiypocyte
DO -
UR -
ER -
김효영 and Dongseok Heo. (2008). The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet. Journal of Korean Medicine Rehabilitation, 18(2), 81-96.
김효영 and Dongseok Heo. 2008, "The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet", Journal of Korean Medicine Rehabilitation, vol.18, no.2 pp.81-96.
김효영, Dongseok Heo "The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet" Journal of Korean Medicine Rehabilitation 18.2 pp.81-96 (2008) : 81.
김효영, Dongseok Heo. The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet. 2008; 18(2), 81-96.
김효영 and Dongseok Heo. "The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 81-96.
김효영; Dongseok Heo. The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet. Journal of Korean Medicine Rehabilitation, 18(2), 81-96.
김효영; Dongseok Heo. The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet. Journal of Korean Medicine Rehabilitation. 2008; 18(2) 81-96.
김효영, Dongseok Heo. The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet. 2008; 18(2), 81-96.
김효영 and Dongseok Heo. "The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 81-96.
