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Neuroprotective Effects of Sopung-tang(Shufeng-tang) on Cognition and Motor Function Recovery after Ischemic Brain Injury in Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2008, 18(2), pp.45-60
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

추민규 1 Misook Shin 2 choi jin bong 1 김선종 1

1동신대학교
2부산대학교

Accredited

ABSTRACT

Objectives : Sopung-tang(Shufeng-tang) is a famous herbal prescription that treated ischemic brain injury. This study was designed to evaluate the effects of Sopung-tang(Shufeng-tang) on congnition and motor function recovery after ischemic brain injury in rats. Methods : Male rats were divided into 4 groups. Those rats caused ischemic brain injury by occlusion of MCA as Longa method. Control groupⅠwas per os normal saline for 7 days after ischemic brain injury. Control group Ⅱ was per os normal saline for 14 days after ischemic brain injury. Experimental groupⅠ(Ex Ⅰ) was taken with Sopung-tang(Shufeng-tang) for 7 days after ischemic brain injury. Experimental group Ⅱ(Ex Ⅱ) was taken with Sopung-tang(Shufeng-tang) for 14 days after ischemic brain injury. The author carried out neurological, cognitive motor behavior tests and histological assessment. Neurological motor behavior tests consist of limb placement test, beam-walking test and horizontal wire test. Morris water maze test was used for cognitive motor behavior test. In the histological assessment test, TTC(2,3,5-triphenylteterazolium chloride) staining, Hematoxylin & Eosin staining and immunohistochemical staining were experimented. Results : 1. In neurological motor behavior tests, motor function recovery was significantly increased in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 2. In Morris water maze test, congnitive motor function recovery was significantly incresed in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially most immune reaction was experimented in the Ex Ⅱ. Conclusions : According to the above results, Sopung-tang(Shufeng-tang) can treat on the congnition and motor function recovery after ischemic brain injury in rats. And it is effective method in expression of BDNF in hippocampus.

Citation status

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