@article{ART001233037},
author={정벌 and Jongsoo Lee},
title={Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={2},
pages={33-43}
TY - JOUR
AU - 정벌
AU - Jongsoo Lee
TI - Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 33
EP - 43
SN - 1229-1854
AB - Objectives :
Sunghyangjungki-san(Xingxiangzhengqi-san) is a herb decoction prescribed frequently for stroke patients. The present study investigated neuroprotective effects of Sunghyangjungki-san(Xingxiangzhengqi-san) against the ischemic damage of the rat brain. Neuronal cell death under the cerebral ischemia is distinguished with the delayed cell death through apoptosis. Consequently, the effects of Sunghyangjungki-san(Xingxiangzhengqi-san) was evaluated with Bax and Bcl-2 expressions as apoptosis related factors in the brain tissues.
Methods :
The ischemic damage was induced by the middle cerebral artery occlusion(MCAO) method in Sprague-Dawley rats. Water extract of Sunghyangjungki-san(Xingxiangzhengqi-san) was treated for 5 days after the MCAO. Neurological scores and infarct size with TTC were measured. Bax and Bcl-2 expressions in the brain tissues were observed with immunohistochemistry.
Results :
Sunghyangjungki-san(Xingxiangzhengqi-san) treatment improved neurological score significantly at 5 days after the MCAO. Sunghyangjungki-san (Xingxiangzhengqi-san) treatment decreased infarct size by the MCAO, but it was not significant statistically. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment attenuated Bax positive neurons significantly in the cerebral penumbra and the caudate putamen. Bcl-2 positive neurons were increased, but not significant. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment increased Bcl-2/Bax expression ratios significantly in the cerebral penumbra and the caudate putamen.
Conclusions :
These results suggest that Sunghyangjungki-san(Xingxiangzhengqi-san) has a neuroprotective effect on the stroke with modulation of apoptosis related factors.
KW - Sunghyangjungki-san(Xingxiangzhengqi-san);MCAO;Apoptosis;Bcl-2;Bax
DO -
UR -
ER -
정벌 and Jongsoo Lee. (2008). Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats. Journal of Korean Medicine Rehabilitation, 18(2), 33-43.
정벌 and Jongsoo Lee. 2008, "Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats", Journal of Korean Medicine Rehabilitation, vol.18, no.2 pp.33-43.
정벌, Jongsoo Lee "Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats" Journal of Korean Medicine Rehabilitation 18.2 pp.33-43 (2008) : 33.
정벌, Jongsoo Lee. Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats. 2008; 18(2), 33-43.
정벌 and Jongsoo Lee. "Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 33-43.
정벌; Jongsoo Lee. Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats. Journal of Korean Medicine Rehabilitation, 18(2), 33-43.
정벌; Jongsoo Lee. Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats. Journal of Korean Medicine Rehabilitation. 2008; 18(2) 33-43.
정벌, Jongsoo Lee. Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats. 2008; 18(2), 33-43.
정벌 and Jongsoo Lee. "Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 33-43.
