@article{ART001238593},
author={이경무 and Kim, Soon-joong and Seo,Il-bok and Jeong, Su-hyeon},
title={Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={2},
pages={17-31}
TY - JOUR
AU - 이경무
AU - Kim, Soon-joong
AU - Seo,Il-bok
AU - Jeong, Su-hyeon
TI - Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 17
EP - 31
SN - 1229-1854
AB - Objectives : This study was carried out to investigate the effects of Samgi-eum(Sanqi-yin) on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Osteoarthritis was induced by injection of monosodium iodoacetate intraarticularly in both knee joints. Arthritic rats were divided into control and treated group. Control group were taken distilled water for 20days. Treated group were taken extracts of Samgi-eum(Sanqi-yin) by orally for the same duration. Normal group were injected normal saline and taken distilled water. Body weights were measured at 0, 5th, 10th, 15th, 20th day after injection. At the end of the experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan contents of articular cartilages were analyzed by safranine O staining method. The contents of TNF-α, IL-1β and IL-6 in synovial fluids were analyzed by ELISA method. Results : 1. Body weights of the treated group were significantly increased compared with control at 20days after injection. 2. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control. 3. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control and histopathological scores of treated group were significantly decreased compared with control. 4. PG contents in articular cartilages of the treated group were significantly increased compared with control. 5. TNF-α contents in synovial fluids of the treated group were significantly decreased compared with control. Conclusions : According to above results, Samgi-eum(Sanqi-yin) has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it is related with reduced secretion of TNF-α from osteoarthritic chondrocytes and synovial membranes.
KW - Samgi-eum(Sanqi-yin);Osteoarthritis;Proteoglycan;TNF-α
DO -
UR -
ER -
이경무, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. (2008). Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation, 18(2), 17-31.
이경무, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. 2008, "Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats", Journal of Korean Medicine Rehabilitation, vol.18, no.2 pp.17-31.
이경무, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon "Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18.2 pp.17-31 (2008) : 17.
이경무, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon. Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. 2008; 18(2), 17-31.
이경무, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. "Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 17-31.
이경무; Kim, Soon-joong; Seo,Il-bok; Jeong, Su-hyeon. Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation, 18(2), 17-31.
이경무; Kim, Soon-joong; Seo,Il-bok; Jeong, Su-hyeon. Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation. 2008; 18(2) 17-31.
이경무, Kim, Soon-joong, Seo,Il-bok, Jeong, Su-hyeon. Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. 2008; 18(2), 17-31.
이경무, Kim, Soon-joong, Seo,Il-bok and Jeong, Su-hyeon. "Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats" Journal of Korean Medicine Rehabilitation 18, no.2 (2008) : 17-31.