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The Experimental Effect of Haedongpibokhap-bang (Haitongpifuhe-fang) on Collagen-induced Arthritisgroup. So, further studies will be needed.

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2008, 18(2), pp.1-15
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

공상은 1 Minseok Oh 1

1대전대학교

Accredited

ABSTRACT

Objectives : The aim of this study was to know the immuity response of Haedongpibokhap-bang(Haitongpifuhe-fang) to rheumatoid arthritis in collagen-induced arthritis(CIA) mice. Methods : For this purpose, Haedongpibokhap-bang(Haitongpifuhe-fang) was orally administerd to mice with arthritis induced by collagen Ⅱ and then value of immunocyte in spleen, draining lymph node and paw joint and cytokine(IL-6, TNF-α), rheumatoid factor (IgG and IgM) in serum were measured. Results : 1. The arthritis index was significantly decreased. 2. In total cell counts of spleen, DLN and paw joint, the cells in spleen decreased while there was a significant increase in DLN and significant decrease in paw joint. 3. In lymph nodes, CD3+, CD3+/CD69+, CD4+, CD8+ cells increased significantly. 4. In joints, CD3+ and CD11+b/Gr-1+ cells decreased significantly. 5. Serum IL-6 and TNF-α were decreased significantly. 6. Production of serum IgG and IgM decreased significantly. Conclusions : The results present that Haedongpibokhap-bang(Haitongpifuhe-fang) controls abnormal activity of immune system, inhibitig collagen-induced arthritis(CIA).

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