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The Effect of Ecklonia Cava on Expressing of Blood Lipids and UCP-1 of Brown Adipose Tissue(BAT) in Zucker Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2008, 18(4), pp.63-72
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

김현우 1 Hojun Kim 1 박영회 1 Keum Dong-ho 1 이명종 1

1동국대학교

Accredited

ABSTRACT

Objectives : This study was designed to examine the effect of Ecklonia cava on expressing of blood lipids and UCP-1 of brown adipose tissue(BAT) in zucker rats. Methods : Experimental groups were divided into 3 groups: normal group, control group and sample group for 7 separate rats as expriment. Control and sample groups were genetrically modified obesity. All groups didn't impose restrictions on food and water. And we gave a ecklonia cava to sample group for 6 weeks. Ecklonia cava was examined in effects of blood glucose, insulin concentration and UCP-1 in brown adipose tissue. Results : 1. Control and sample groups were increased in weight. But, sample group was decreased as compared to control group. 2. Sample group was decreased significantly as compared to control group with insulin concentration, HOMA, TG, FFA. 3. Sample group was increased significantly as compared to control group with UCP-1 mRNA. Conclusions : Based on these results, it was proved that Ecklonia cava on obesity effects in decreasing blood lipids, increasing UCP-1 of brown adipose tissue.

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