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A Study on the Effect of Changchuldointanggami-bang(Cāngzhútáoréntāngjiāwèi-fāng) in Rheumatoid Arthritis

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2009, 19(4), pp.1-18
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

박은숙 1 Yoon il ji 1

1대전대학교

Accredited

ABSTRACT

Objectives : This study was carried out to understand the immune responses of the Changchuldointanggami-bang(after referred to CDIT) on antioxidants, THP-1 cell and rheumatoid arthritis in Collagen-induced Arthritis(CIA) mice. Methods : The antioxidative effect of CDIT on DPPH free radical and SOD-like activity was measured. CDIT was administered to THP-1 cell, cytokine and mRNA associated with inflammation were measured. CDIT was orallyadministered to mice with arthritis by collagen Ⅱ and then cytokine, PBMC in the serum were measured. Results : 1. The scavenging activity of CDIT on DPPH free radical was dose-dependent. 2. The effect of CDIT on SOD-like activity was dose-dependent. 3. The production of IL-1β, IL-6, TNF-α was decreased significantly in THP-1 cell. 4. The expression of IL-1β mRNA, IL-6mRNA, TNF-α mRNA were decreased significantly in THP-1 cell. 5. IL-1β, IL-6, TNF-α were decreased significantly in the serum of CIA mice. 6. CD3+, CD4+, CD8+ were increased significantly, butCD3+/CD69+, CD3+/CD49b+, B220+/CD23+ were decreased significantly in PBMC of CIA mice. Conclusions : Taking all these observations into account, CDIT is considered to be effective in rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

Citation status

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