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@article{ART001385992},
author={소갑석 and 박영회 and oh jaekeun and 이명종},
title={The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={4},
pages={19-36}

TY - JOUR
AU - 소갑석
AU - 박영회
AU - oh jaekeun
AU - 이명종
TI - The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 19
EP - 36
SN - 1229-1854
AB - Objectives : This experimental study was designed to investigate the effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) on the muscle regeneration of atrophied rat muscle by hindlimb suspension. Materialsandmethods : In this study, Sprague-Dawley rats weighing about 250g were subjected to hindlimb suspension and divided into total four groups: Normal group(n=6), Control group(n=6), Hindlimb non-treatment group(n=6), Hindlimb treatment group(n=6). Experiments were seperately tried two times. The first trial was studied by the following two groups; The first was normal group(n=6). The second was group(n=18) for hindlimb suspension during 2 weeks (control I group). The second trial after 2 weeks hindlimb suspension was studied by the following three groups; The third group(n=6) was expired immediately after 2 week shindlimb suspension. The forth group(n=6) was given free activity during 2 weeks after 2 weeks hindlimb suspension. The fifth group(n=6) was administrated of KST during 2 weeks after 2 week shindlimb suspension. In order to investigate degree of muscle atrophy, body weight and gastrocnemius muscle mass were compared. To analyze muscle regeneration factors(expression of IGF-1, Myogenin, MyoD), Western blot was used. Results : The results were analyzed by statistical process as follows, 1. In body weight, all hindlimb suspension groups were lower than normal group, but tendency of increase was shown in KST group compared to non-treatment group after 2 weeks hindlimb suspension. 2. In gastrocnemius muscle mass, KST group on both side was significantly higher than non-treatment group after 2 weeks hindlimb suspension. 3. In case of IGF-I, Type Ⅰ of KST group was significantly increased than non-treatment group, but Type Ⅱ was not shown significance. 4. There was no significantly difference in Myogenin. 5. In MyoD, TypeⅠ of KST group was significantly increased than control group, and Type Ⅱ of KST group was significantly increased than non-treatment group. Conclusions : Insummary, this study demonstrates that KST administration has an effect to prevent muscle atrophy and contribute muscle regeneration and proliferation. And also it is suggested that IGF-Ⅰ and MyoD is major factors of myogenesis expression to KST adminstration after hindlimb suspension.
KW - KangwhalSokdan-tang(Jianghuoxuduan-tang);Muscle atrophy;Muscle regeneration;Hindlimb suspension;IGF-Ⅰ;Myogenin;MyoD
DO -
UR -
ER -

소갑석, 박영회, oh jaekeun and 이명종. (2009). The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension. Journal of Korean Medicine Rehabilitation, 19(4), 19-36.

소갑석, 박영회, oh jaekeun and 이명종. 2009, "The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension", Journal of Korean Medicine Rehabilitation, vol.19, no.4 pp.19-36.

소갑석, 박영회, oh jaekeun, 이명종 "The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension" Journal of Korean Medicine Rehabilitation 19.4 pp.19-36 (2009) : 19.

소갑석, 박영회, oh jaekeun, 이명종. The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension. 2009; 19(4), 19-36.

소갑석, 박영회, oh jaekeun and 이명종. "The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 19-36.

소갑석; 박영회; oh jaekeun; 이명종. The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension. Journal of Korean Medicine Rehabilitation, 19(4), 19-36.

소갑석; 박영회; oh jaekeun; 이명종. The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension. Journal of Korean Medicine Rehabilitation. 2009; 19(4) 19-36.

소갑석, 박영회, oh jaekeun, 이명종. The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension. 2009; 19(4), 19-36.

소갑석, 박영회, oh jaekeun and 이명종. "The Effect of KangwhalSokdan-tang(Jianghuoxuduan-tang) Administration on Muscle Regeneration in Atrophied Rat Muscle Induced by Hindlimb Suspension" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 19-36.