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@article{ART001385993},
author={신영진 and Hojun Kim and 이명종 and Keum Dong-ho},
title={The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={4},
pages={37-58}

TY - JOUR
AU - 신영진
AU - Hojun Kim
AU - 이명종
AU - Keum Dong-ho
TI - The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 37
EP - 58
SN - 1229-1854
AB - Objectives : This study was performed to investigate the effects of fermented Ephedra sinica (FMH) nano-extract compared Ephedra sinica (MH) on 3T3 L1 cell viability, lipid and glycometabolism, Obes rats' behavior and state-trait anxiety. Methods and materials : Each of 6 rats was divided into a normal diet, HFD, MH, and FMH. We fed a HFD group of rats a high fat diet and administered normal saline for 8 weeks. And we fed an experimental group of rats a high fat diet and administered an extract of Ephedra sinica and fermentated Ephedra sinica for 8 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. Ephedra sinica and fermentated Ephedra sinica was examined in effects of 3T3 L1 cell viability, lipid and glycometabolism, rats' behavior and state-trait anxiety. Results : 1. Ephedra sinica and fermentated Ephedra sinica didn't induce cytotoxicity at 3L3 L1 cell. 2. Fermentated Ephedra sinicaby Lactococcus confusus inhibit PPAR-γ activation and promote TNF-α activation. 3. In MH and FMH group, the body weight and FER decrease occured significantly than in HFD group. 4. No side effect of Ephedra sinica appeared in FMH group, so fermentated Ephedra sinica have a capacity of anti-anxiety. 5. Serum total cholesterol, triglyceride, HDL-cholesterol and creatine of HFD+Ephedra sinica, HFD+LO group were decreased compared with that of HFD group. Decreasing rates of sample group was significant(p<0.05). 6. In both MH and FMH group serum HDL was increased(P>0.05). 7. In MH group only TG was decreased, but in FMH group total cholesterol, TG, and glucose were decreased(P>0.05). Conclusions : Fermentated Ephedra sinica by Lactococcus confusus was superior to Ephedra sinica in capacity of anti-obesity. Further fermentated Ephedra sinica have no Ephedra sinica's side effect.
KW - Fermentated Mahuang;Mahuang;Obesity;Ephedra sinica
DO -
UR -
ER -

신영진, Hojun Kim, 이명종 and Keum Dong-ho. (2009). The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet. Journal of Korean Medicine Rehabilitation, 19(4), 37-58.

신영진, Hojun Kim, 이명종 and Keum Dong-ho. 2009, "The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet", Journal of Korean Medicine Rehabilitation, vol.19, no.4 pp.37-58.

신영진, Hojun Kim, 이명종, Keum Dong-ho "The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet" Journal of Korean Medicine Rehabilitation 19.4 pp.37-58 (2009) : 37.

신영진, Hojun Kim, 이명종, Keum Dong-ho. The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet. 2009; 19(4), 37-58.

신영진, Hojun Kim, 이명종 and Keum Dong-ho. "The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 37-58.

신영진; Hojun Kim; 이명종; Keum Dong-ho. The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet. Journal of Korean Medicine Rehabilitation, 19(4), 37-58.

신영진; Hojun Kim; 이명종; Keum Dong-ho. The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet. Journal of Korean Medicine Rehabilitation. 2009; 19(4) 37-58.

신영진, Hojun Kim, 이명종, Keum Dong-ho. The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet. 2009; 19(4), 37-58.

신영진, Hojun Kim, 이명종 and Keum Dong-ho. "The Effects of Fermentated Ephedra sinica on Obese Rats Fed by High Fat Diet" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 37-58.