@article{ART001385998},
author={한애리 and SOHN NAK-WON and Chung, Seok Hee and Kim Sung-Soo and Mi-Yeon Song},
title={Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={4},
pages={95-114}
TY - JOUR
AU - 한애리
AU - SOHN NAK-WON
AU - Chung, Seok Hee
AU - Kim Sung-Soo
AU - Mi-Yeon Song
TI - Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 95
EP - 114
SN - 1229-1854
AB - Objectives :
Saengbal-eum-II(Shēngfà-yĭn-II) is a hair care product which is composed of ten plant extracts used in oriental medicine. This study was carried out to investigate the effects of Saengbal-eum-II(Shēngfà-yĭn-II) on hair regrowth and cytokine changes in a shaving model of C57BL/6 mice.
Materials and Methods :
Five-week-old mice were acclimated for 1 week at a temperature between 21-23℃, 40-60% relative humidity, and 12h of a light/dark cycle before beginning of the experiment. There were three experimental groups including 50% ethanol (EtOH, control), a positive control of 3% Minoxidil, and 30% Saengbal-eum-II(Shēngfà-yĭn-II) in 50% ethanol in 18 female mice. The test compounds were topically treated once a day over 12 days. The hair regrowth was photographically and histologically determined during the experimental period of 12 days. Revelation of EGF, TGF-β1 and IL-6 in hair follicle were also determined using immunohistochemistry. In addition to that, IL-6, TNF-α, and IL-1β in skin tissue were determined using enzyme-linked immunosorbent assay(ELISA).
Results :
Hair regrowth in 3% Minoxidil and Saengbal-eum-II(Shēngfà-yĭn-II) groups was promoted earlier and faster than the control group. Concentrations of hairs and thick-hair ratio in 3% Minoxidil and Saengbal-eum-II(Shēngfà-yĭn-II) groups were promoted than the control group. EGF was moderately positive in hair follicle of 3% Minoxidil and Saengbal-eum-II(Shēngfà-yĭn-II) groups, but negative in the control group. TGF-β1 was not significantly difference between the groups. IL-6 in hair follicle of Saengbal-eum-II(Shēngfà-yĭn-II) group was negative, but weakly positive in 3% Minoxidil and control group. IL-6 and IL-1β in skin tissue were significantly decreased in Saengbal-eum-II(Shēngfà-yĭn-II) group, but there was not significantly decreased in 3% Minoxidil and control group. TNF-α in skin tissue was significantly decreased in 3% Minoxidil and Saengbal-eum-II(Shēngfà-yĭn-II) groups.
Conclusions :
These results suggest that Saengbal-eum-II(Shēngfà-yĭn-II) has hair growth promoting activity and it can be used for treatment of alopecia. And these effects relate to EGF revelation of hair follicle and a decrease IL-6, TNF-α, and IL-1β in skin tissue.
KW - Alopecia;C57BL/6 mice;Saengbal-eum-II(Shēngfà-yĭn-II);Cytokine;Hair regrowth
DO -
UR -
ER -
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo and Mi-Yeon Song. (2009). Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice. Journal of Korean Medicine Rehabilitation, 19(4), 95-114.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo and Mi-Yeon Song. 2009, "Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice", Journal of Korean Medicine Rehabilitation, vol.19, no.4 pp.95-114.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo, Mi-Yeon Song "Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice" Journal of Korean Medicine Rehabilitation 19.4 pp.95-114 (2009) : 95.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo, Mi-Yeon Song. Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice. 2009; 19(4), 95-114.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo and Mi-Yeon Song. "Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 95-114.
한애리; SOHN NAK-WON; Chung, Seok Hee; Kim Sung-Soo; Mi-Yeon Song. Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice. Journal of Korean Medicine Rehabilitation, 19(4), 95-114.
한애리; SOHN NAK-WON; Chung, Seok Hee; Kim Sung-Soo; Mi-Yeon Song. Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice. Journal of Korean Medicine Rehabilitation. 2009; 19(4) 95-114.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo, Mi-Yeon Song. Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice. 2009; 19(4), 95-114.
한애리, SOHN NAK-WON, Chung, Seok Hee, Kim Sung-Soo and Mi-Yeon Song. "Study on Effect of Saengbal-eum-II(Shēngfà-yĭn-Ⅱ) on Hair Regrowth Promotion in C57BL/6 Mice" Journal of Korean Medicine Rehabilitation 19, no.4 (2009) : 95-114.