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@article{ART001465248},
author={유덕선 and Seung-ryong Yeom and Young Dal Kwon and SONG YUNG SUN},
title={Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2010},
volume={20},
number={3},
pages={1-11}

TY - JOUR
AU - 유덕선
AU - Seung-ryong Yeom
AU - Young Dal Kwon
AU - SONG YUNG SUN
TI - Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2010
VL - 20
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 11
SN - 1229-1854
AB - Objectives :This study was designed to investigate the effects of Lumbricus extract(LE) on the regional cerebral blood flow(rCBF) in ischemic rats, further to determine the mechanism of action of LE, and the effects that LE inhibits lactate dehydrogenase(LDH) activity in brain cells. Methods and materials :This study, ischemic rats were divided into total four group: control group(n=6), experimental group Ⅰ(LE treated group)(n=6), experimental group Ⅱ(LE treated group after pretreatment with indomethacin)(n=6), experimental group Ⅲ(LE treated group after pretreatment with methylene blue)(n=6). And the measurement that LE inhibits LDH activity in the damage to brain cells to N-methyl-D-aspartic acid(NMDA). The changes of rCBF were determinated by laser-doppler flowmetry(LDF), and LDH activity was determinated by microplate reader in vitro. Results :1. The rCBF was significantly improved by LE(10 ㎎/㎏, i.p.) during the period of cerebral reperfusion, compared with the control group. 2. The rCBF was significantly increased by LE after pretreatment with indomethacin(1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, during the period of cerebral reperfusion, compared with the LE group, and rCBF was accelerated by LE after pretreatment with methylene blue(10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase during the period of cerebral reperfusion, compared with the control group. 3. LE significantly inhibited LDH activity in vitro in a dose-dependent manner. Conclusions :From the above results, these were suggested that Lumbricus had anti-ischemia action in connection with cyclooxygenase and might prevent the brain cells death through inhibited LDH activity.
KW - Key words : Lumbricus;Cerebral ischemia;Cerebral cells;Regional cerebral blood flow(rCBF)
DO -
UR -
ER -

유덕선, Seung-ryong Yeom, Young Dal Kwon and SONG YUNG SUN. (2010). Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats. Journal of Korean Medicine Rehabilitation, 20(3), 1-11.

유덕선, Seung-ryong Yeom, Young Dal Kwon and SONG YUNG SUN. 2010, "Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats", Journal of Korean Medicine Rehabilitation, vol.20, no.3 pp.1-11.

유덕선, Seung-ryong Yeom, Young Dal Kwon, SONG YUNG SUN "Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats" Journal of Korean Medicine Rehabilitation 20.3 pp.1-11 (2010) : 1.

유덕선, Seung-ryong Yeom, Young Dal Kwon, SONG YUNG SUN. Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats. 2010; 20(3), 1-11.

유덕선, Seung-ryong Yeom, Young Dal Kwon and SONG YUNG SUN. "Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats" Journal of Korean Medicine Rehabilitation 20, no.3 (2010) : 1-11.

유덕선; Seung-ryong Yeom; Young Dal Kwon; SONG YUNG SUN. Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats. Journal of Korean Medicine Rehabilitation, 20(3), 1-11.

유덕선; Seung-ryong Yeom; Young Dal Kwon; SONG YUNG SUN. Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats. Journal of Korean Medicine Rehabilitation. 2010; 20(3) 1-11.

유덕선, Seung-ryong Yeom, Young Dal Kwon, SONG YUNG SUN. Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats. 2010; 20(3), 1-11.

유덕선, Seung-ryong Yeom, Young Dal Kwon and SONG YUNG SUN. "Effects of Lumbricus Extract on Cerebral Ischemia and Cells in Rats" Journal of Korean Medicine Rehabilitation 20, no.3 (2010) : 1-11.