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Anti-inflammatory Effect of Artemisia Capillaris Thunberg in Lipopolysaccharide-exposed Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2010, 20(3), pp.27-35
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

서용석 1,  Lee,Eun 2,  Cha Yun Yeop 3

1상지대학교 한의과대학 한방재활의학과교실
2상지대학교 보건과학대학 제약공학과
3상지대학교

Accredited

ABSTRACT

Objectives :The present study investigated anti-inflammatory effect of Artemisia Capillaris Thunberg in lipopolysaccharide-exposed rats. Methods :We divided lipopolysaccharide-exposed Sprague-Dawley rats into 4 groups. They were normal group, feed with 100 mg/kg Artemisia Capillaris Thunberg group, feed with 200 mg/kg Artemisia Capillaris Thunberg group and feed with 300 mg/kg Artemisia capilaris Thunberg group. They were administered for 6 weeks. We measured counts of red blood cell(RBC), the values of hemoglobin(Hb) and packed cell volume(PCV), plasma total protein concentration, albumin concentration, the ratio of albumin/globulin, the activities of plasma glutamic oxaloacetic transaminase(GOT), glutamic pyruvic transaminase(GPT), lactate dehydrogenase(LDH), the counts of white blood cell(WBC), the ratio of neutrophils, lymphocytes, monocytes, basophils, eosinophils, the concentration of plasma interleukin-1β(IL-1β), plasma interleukin-6(IL-6), plasma tumor necrosis factor-α(TNF-α), plasma interleukin-10(IL-10), the concentration of liver IL-1β and IL-6, TNF-α, IL-10. Results :Counts of RBC and the values of Hb and PCV, plasma total protein concentration and albumin concentration, the activities of plasma GOT, GPT and LDH showed no significant difference in the treatment groups. and the ratio of albumin/globulin was increased in Artemisia Capillaris Thunberg groups. The counts of WBC showed lower values in Artemisia Capillaris Thunberg groups than those of control group, In the ratio of neutrophils, Artemisia Capillaris Thunberg groups showed lower values than control group, however the ratio of lymphocytes was increased in the Artemisia Capillaris Thunberg groups. The ratio of monocytes, basophils and eosinophils were below 5%, and showed no characteristic trend. The concentration of plasma interleukin-1β(IL-1β), plasma interleukin-6(IL-6) and plasma tumor necrosis factor-α(TNF-α) showed a lower values in the Artemisia Capillaris Thunberg groups than those of control group, and the concentration of plasma interleukin-10(IL-10) showed no significant difference in the treatment groups. The concentration of liver IL-1β and IL-6 showed a lower values in the Artemisia Capillaris Thunberg groups than those of control group, however the concentration of liver TNF-α and IL-10 showed no significant difference in the treatment groups. Conclusions :The Artemisia Capillaris Thunberg groups gives positive results of anti-inflammatory response by lipopolysaccharide(LPS) derivation.

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