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@article{ART001547401},
author={유덕선 and Seung-ryong Yeom and LEE SU KYUNG and Young Dal Kwon and SONG YUNG SUN},
title={The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={2},
pages={101-123}

TY - JOUR
AU - 유덕선
AU - Seung-ryong Yeom
AU - LEE SU KYUNG
AU - Young Dal Kwon
AU - SONG YUNG SUN
TI - The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 101
EP - 123
SN - 1229-1854
AB - Objectives :The aim was to study the effect of bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model. Methods :We enforced a bee venom pharmacopuncture therapy with different concentration on rheumatoid arthritis rat model by the intradermal injection of chicken type Ⅱ collagen emulsified. 14 days after the onset of the rheumatoid arthritis rat model, a fixed volume of bee venom was daily injected to ST-35 acupoint in the rat's knee joint for 2-3 weeks. The hind paw volume, arthritic index, arthritic flexion pain test, pain threshold, and serum analysis(CRP, PGE2, ALT, AST) were analyzed, and the expression profiles of COX-2, c-fos, and substance-P at the dorsal horn region of the spinal cord and subchondral bone of the knee joint were also analyzed by using the immunohistochemistry. Results :After the treatment of rheumatoid arthritis rats with bee venom pharmacopuncture, the paw volume of edema of arthritic rats were almost restored to the level of normal group, and behavior tests were very effective. Also the evaluation on the blood serum analysis was remarkable. COX-2, c-fos, and substance-P positive cells in the immunohistological section of dorsal horn region of the spinal cord and subchondral bone of the knee joints were significantly decreased. also the bee venom pharmacopuncture was effective to alleviate their rheumatoid arthritic inflammation cytokine inhibition as regards to the behavior tests and joint histological appearance. Conclusions :Based on the results in this study, bee venom pharmacopuncture with concentrated treatment condition was very effective in low fixed quantity and progressive low increased quantity.
KW - Bee venom pharmacopuncture therapy;Concentrated treatment condition;Rheumatoid arthritis
DO -
UR -
ER -

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon and SONG YUNG SUN. (2011). The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model. Journal of Korean Medicine Rehabilitation, 21(2), 101-123.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon and SONG YUNG SUN. 2011, "The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model", Journal of Korean Medicine Rehabilitation, vol.21, no.2 pp.101-123.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon, SONG YUNG SUN "The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model" Journal of Korean Medicine Rehabilitation 21.2 pp.101-123 (2011) : 101.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon, SONG YUNG SUN. The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model. 2011; 21(2), 101-123.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon and SONG YUNG SUN. "The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 101-123.

유덕선; Seung-ryong Yeom; LEE SU KYUNG; Young Dal Kwon; SONG YUNG SUN. The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model. Journal of Korean Medicine Rehabilitation, 21(2), 101-123.

유덕선; Seung-ryong Yeom; LEE SU KYUNG; Young Dal Kwon; SONG YUNG SUN. The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model. Journal of Korean Medicine Rehabilitation. 2011; 21(2) 101-123.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon, SONG YUNG SUN. The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model. 2011; 21(2), 101-123.

유덕선, Seung-ryong Yeom, LEE SU KYUNG, Young Dal Kwon and SONG YUNG SUN. "The Effect of Bee Venom Pharmacopuncture Therapy on the Condition of Different Concentration in Rheumatoid Arthritis Rat Model" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 101-123.