@article{ART001547402},
author={은영준 and SONG YUN KYUNG and Lim Hyung Ho},
title={Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={2},
pages={125-142}
TY - JOUR
AU - 은영준
AU - SONG YUN KYUNG
AU - Lim Hyung Ho
TI - Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 125
EP - 142
SN - 1229-1854
AB - Objectives :Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficits. The purpose of this study was to evaluate the effects of Haein-tang(Hairen-tang) extract on functional recovery and pain release in the sciatic nerve after crushed sciatic nerve injury in rats.
Methods :1. Sciatic functional index(SFI) were performed on functional recovery.
2. c-Fos immunohistochemistry were performed on c-Fos expressions in the paraventricular nucleus(PVN) and ventrolateral periaqueductal gray(vlPAG).
3. Neurofilament immunohistochemistry were performed on neurofilament regeneration.
4. Western blot were performed on brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF) expression.
Results :1. Haein-tang(Hairen-tang) extract significantly enhanced the SFI value in the sciatic nerve injury and 100 mg/kg, 200 mg/kg Haein-tang(Hairen-tang)-treated group.
2. Haein-tang(Hairen-tang) extract significantly suppressed the sciatic nerve injury-induced increment of c-Fos expressions in the PVN and vlPAG in the sciatic nerve injury and 100 mg/kg, 200 mg/kg Haein-tang(Hairen-tang)-treated group.
3. Haein-tang(Hairen-tang) extract significantly increased neurofilament expression in the sciatic nerve injury and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang (Hairen-tang)-treated group.
4. Haein-tang(Hairen-tang) extract significantly controled the sciatic nerve injury-induced increment of BDNF and NGF expressions in the sciatic nerve injury and 100 mg/kg, 200 mg/kg Haein-tang(Hairen-tang)-treated group.
Conclusions :These results suggest that Haein-tang(Hairen-tang) treatment after sciatic nerve injury is effective for the functional recovery by enhancing of axonal regeneration and suppressing of pain.
KW - Haein-tang(Hairen-tang);Sciatic nerve injury;Sciatic functional index;Nerve growth factor;c-Fos
DO -
UR -
ER -
은영준, SONG YUN KYUNG and Lim Hyung Ho. (2011). Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats. Journal of Korean Medicine Rehabilitation, 21(2), 125-142.
은영준, SONG YUN KYUNG and Lim Hyung Ho. 2011, "Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats", Journal of Korean Medicine Rehabilitation, vol.21, no.2 pp.125-142.
은영준, SONG YUN KYUNG, Lim Hyung Ho "Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats" Journal of Korean Medicine Rehabilitation 21.2 pp.125-142 (2011) : 125.
은영준, SONG YUN KYUNG, Lim Hyung Ho. Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats. 2011; 21(2), 125-142.
은영준, SONG YUN KYUNG and Lim Hyung Ho. "Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 125-142.
은영준; SONG YUN KYUNG; Lim Hyung Ho. Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats. Journal of Korean Medicine Rehabilitation, 21(2), 125-142.
은영준; SONG YUN KYUNG; Lim Hyung Ho. Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats. Journal of Korean Medicine Rehabilitation. 2011; 21(2) 125-142.
은영준, SONG YUN KYUNG, Lim Hyung Ho. Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats. 2011; 21(2), 125-142.
은영준, SONG YUN KYUNG and Lim Hyung Ho. "Effects of Haein -tang(Hairen -tang ) Extract on Functional Recovery in Sciatic Nerve and c-Fos Expression in the Brain after Crushed Sciatic Nerve Injury in Rats" Journal of Korean Medicine Rehabilitation 21, no.2 (2011) : 125-142.