@article{ART001597599},
author={송상훈 and 이준석 and 신정원 and Seong-Joon Kim and SOHN NAK-WON},
title={An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={4},
pages={1-12}
TY - JOUR
AU - 송상훈
AU - 이준석
AU - 신정원
AU - Seong-Joon Kim
AU - SOHN NAK-WON
TI - An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 12
SN - 1229-1854
AB - Objectives :This study was carried out in order to examine the effects of Gastrodiae rhizoma(GR) ethanol extract on neuronal apoptosis in intracerebral hemorrhage(ICH)-induced rats.
Methods :ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. GR was orally given once a day for 3 days after ICH. Histological changes of the peri-hematoma regions were observed by cresyl violet staining. Bcl-2-associated X protein(Bax), B-cell blastoma 2(Bcl-2) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL) expressions in the affected regions were performed by immunohistochemistry.
Results :1. GR reduced apoptotic bodies and swelling neurons in the peri-hematoma regions of ICH-induced rats.
2. GR significantly reduced TUNEL positive cells in the peri-hematoma regions of ICH-induced rats.
3. GR significantly reduced Bax positive cells in the peri-hematoma regions of ICH-induced rats.
4. GR did not influence Bcl-2 expression in the peri-hematoma regions of ICH-induced rats.
Conclusions :These results suggest that GR has neuroprotective effects against ICH-induced apoptosis.
KW - Intracerebral hemorrhage;Gastrodiae rhizoma;Neuronal apoptosis;TUNEL;Bax;Bcl-2
DO -
UR -
ER -
송상훈, 이준석, 신정원, Seong-Joon Kim and SOHN NAK-WON. (2011). An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. Journal of Korean Medicine Rehabilitation, 21(4), 1-12.
송상훈, 이준석, 신정원, Seong-Joon Kim and SOHN NAK-WON. 2011, "An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats", Journal of Korean Medicine Rehabilitation, vol.21, no.4 pp.1-12.
송상훈, 이준석, 신정원, Seong-Joon Kim, SOHN NAK-WON "An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats" Journal of Korean Medicine Rehabilitation 21.4 pp.1-12 (2011) : 1.
송상훈, 이준석, 신정원, Seong-Joon Kim, SOHN NAK-WON. An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. 2011; 21(4), 1-12.
송상훈, 이준석, 신정원, Seong-Joon Kim and SOHN NAK-WON. "An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 1-12.
송상훈; 이준석; 신정원; Seong-Joon Kim; SOHN NAK-WON. An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. Journal of Korean Medicine Rehabilitation, 21(4), 1-12.
송상훈; 이준석; 신정원; Seong-Joon Kim; SOHN NAK-WON. An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. Journal of Korean Medicine Rehabilitation. 2011; 21(4) 1-12.
송상훈, 이준석, 신정원, Seong-Joon Kim, SOHN NAK-WON. An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats. 2011; 21(4), 1-12.
송상훈, 이준석, 신정원, Seong-Joon Kim and SOHN NAK-WON. "An Immunohistochemical Study on Effect of Gastrodiae Rhizoma against Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 1-12.