@article{ART001597600},
author={반효정 and 김범회 and 신정원 and 박성하 and Seong-Joon Kim and SOHN NAK-WON and Jong-Jin Jo},
title={Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={4},
pages={13-22}
TY - JOUR
AU - 반효정
AU - 김범회
AU - 신정원
AU - 박성하
AU - Seong-Joon Kim
AU - SOHN NAK-WON
AU - Jong-Jin Jo
TI - Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 13
EP - 22
SN - 1229-1854
AB - Objectives :This study was performed to evaluate the effects of Scutellariae Radix(SR) water-extract on the tissue and neuronal apoptosis of the spinal cord injury(SCI).
Methods :SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rats. SR was orally given once a day for 7 days after SCI. Neuronal apoptosis was examined with terminal deoxynucleotidyl transferase-mediated dUTPnick-end labeling(TUNEL) assay. Bax (Bcl-2-asociated X protein), Bcl-2(B-cell blastoma 2), c-Fos(FBJ osteosarcoma oncogene) expressions were examined using immuno-histochemistry. Individual TUNEL and immuno-labeled cells expressing Bax, Bcl-2 and c-Fos were counted on the same level in peri-damaged region and in ventral horn.
Results :1. SR significantly reduced number of TUNEL labeled apoptotic cells induced by the spinal cord contusion injury.
2. SR significantly reduced Bax positive cells expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury.
3. SR strengthened Bcl-2 expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury.
4. SR reduced c-Fos expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury.
Conclusions :These results suggest that SR plays an inhibitory role against neuronal apoptosis and has significant effects for locomotor dysfunction induced by SCI.
KW - Scutellariae Radix;Spinal cord injury;Apoptosis;TUNEL;Bax;Bcl-2
DO -
UR -
ER -
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON and Jong-Jin Jo. (2011). Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats. Journal of Korean Medicine Rehabilitation, 21(4), 13-22.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON and Jong-Jin Jo. 2011, "Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats", Journal of Korean Medicine Rehabilitation, vol.21, no.4 pp.13-22.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON, Jong-Jin Jo "Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats" Journal of Korean Medicine Rehabilitation 21.4 pp.13-22 (2011) : 13.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON, Jong-Jin Jo. Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats. 2011; 21(4), 13-22.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON and Jong-Jin Jo. "Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 13-22.
반효정; 김범회; 신정원; 박성하; Seong-Joon Kim; SOHN NAK-WON; Jong-Jin Jo. Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats. Journal of Korean Medicine Rehabilitation, 21(4), 13-22.
반효정; 김범회; 신정원; 박성하; Seong-Joon Kim; SOHN NAK-WON; Jong-Jin Jo. Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats. Journal of Korean Medicine Rehabilitation. 2011; 21(4) 13-22.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON, Jong-Jin Jo. Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats. 2011; 21(4), 13-22.
반효정, 김범회, 신정원, 박성하, Seong-Joon Kim, SOHN NAK-WON and Jong-Jin Jo. "Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 13-22.