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Effects of Scutellariae Radix on Neuronal Apoptosis of Spinal Cord Contusion Injury in Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2011, 21(4), pp.13-22
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

반효정 1 김범회 2 신정원 1 박성하 3 Seong-Joon Kim 1 SOHN NAK-WON 1 Jong-Jin Jo 4

1경희대학교
2동의대학교
3부산대학교
4자생한방병원

Accredited

ABSTRACT

Objectives :This study was performed to evaluate the effects of Scutellariae Radix(SR) water-extract on the tissue and neuronal apoptosis of the spinal cord injury(SCI). Methods :SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rats. SR was orally given once a day for 7 days after SCI. Neuronal apoptosis was examined with terminal deoxynucleotidyl transferase-mediated dUTPnick-end labeling(TUNEL) assay. Bax (Bcl-2-asociated X protein), Bcl-2(B-cell blastoma 2), c-Fos(FBJ osteosarcoma oncogene) expressions were examined using immuno-histochemistry. Individual TUNEL and immuno-labeled cells expressing Bax, Bcl-2 and c-Fos were counted on the same level in peri-damaged region and in ventral horn. Results :1. SR significantly reduced number of TUNEL labeled apoptotic cells induced by the spinal cord contusion injury. 2. SR significantly reduced Bax positive cells expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. 3. SR strengthened Bcl-2 expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. 4. SR reduced c-Fos expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. Conclusions :These results suggest that SR plays an inhibitory role against neuronal apoptosis and has significant effects for locomotor dysfunction induced by SCI.

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