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@article{ART001597601},
author={공인표 and 박원형 and Cha Yun Yeop},
title={Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2011},
volume={21},
number={4},
pages={23-40}

TY - JOUR
AU - 공인표
AU - 박원형
AU - Cha Yun Yeop
TI - Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet
JO - Journal of Korean Medicine Rehabilitation
PY - 2011
VL - 21
IS - 4
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 23
EP - 40
SN - 1229-1854
AB - Objectives :This study was designed to examine the effects of extracts of Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) on the lipid lowering, anti-oxidation and concentration of proinflammatory cytokines and was investigated on hyperlipidemic rats. Methods :Male rats weighing 182.39±4.71 g were fed high fat diet for 8 weeks and 36 rats(above 400 g) were divided into 4 groups. Each of 9 rats was divided into a control group and experimental groups. We fed a control group of rats a basal diet and administered normal saline(100 mg/kg, 1 time/1 day) for 4 weeks. And we fed each experimental group of rats basal diet and administered an extract of Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) extracts(100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. We measured lipid of plasma and liver, concentration of proinflammatory cytokines, anti-oxidative activity and TNF-α, Apo-B, Apo-E and leptin gene expression. Results :1. Concentration of plasma free fatty acid(FFA) showed no significant difference in all the treatment groups. Concentration of plasma triglyceride(TG) showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups than that of control group. 2. Concentration of plasma total cholesterol showed a significant decrement in the 200 and 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups than that of control group. Concentration of plasma low density lipoprotein(LDL)-cholesterol showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups than that of control group. Concentration of plasma high density lipoprotein(HDL)-cholesterol showed a significant increment in the 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups. 3. Concentration of liver total cholesterol showed a tendence to decrease in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups. Concentration of liver TG showed a significant decrement in all Ojeoksangamibang groups than that of control group. 4. Concentration of plasma and liver thiobarbituric acid reactive substance(TBARS) showed a tendence to decrease in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups. 5. The values of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) activity showed a significant increment in all Ojeoksangamibang (Wǔjīsǎnjiāwèifāng) groups than that of control group. 6. The values of plasma aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity showed no significant difference in all treatment groups. 7. Concentration of plasma interleukin(IL)-1β showed no significant difference in all the treatment groups. Concentration of plasma IL-6 showed a significant decrement in the 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups than that of control group. Concentration of plasma tumor necrosis factor-α (TNF-α) a significant decrement in the 200 and 300 mg/kg in Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups than that of control group. However the concentration of plasma IL-10 in the 300 mg/kg Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups showed a significant increment than that of control group. 8. Concentration of liver IL-1β, TNF-α, IL-6 and IL-10 showed no significant difference in among treatment groups. 9. In the analysis of reverse transcription-polymerase chain reaction(RT-PCR), gene expression of TNF-α, Apo-B and Apo-E in the Ojeoksangamibang (Wǔjīsǎnjiāwèifāng) groups showed a lower expression than that of control group. However the gene expression of leptin showed no difference in the treatment groups. 10. The ratio of TNF-α, Apo-B and Apo-E per β-actin expression in the Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) groups showed a significant decrement than that of control group. However The ratio of leptin expression per β-actin expression showed no significant difference among all the treatment groups. Conclusions :According to above results, in lowering lipid effect, anti-oxidation and control of pro-inflammatory cytokines production, Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) gives positive effect.
KW - Ojeoksangamibang(Wǔjīsǎnjiāwèifāng);Pro-inflammatory cytokines;Lowering lipid effect;Antioxidation effect
DO -
UR -
ER -

공인표, 박원형 and Cha Yun Yeop. (2011). Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. Journal of Korean Medicine Rehabilitation, 21(4), 23-40.

공인표, 박원형 and Cha Yun Yeop. 2011, "Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet", Journal of Korean Medicine Rehabilitation, vol.21, no.4 pp.23-40.

공인표, 박원형, Cha Yun Yeop "Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet" Journal of Korean Medicine Rehabilitation 21.4 pp.23-40 (2011) : 23.

공인표, 박원형, Cha Yun Yeop. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. 2011; 21(4), 23-40.

공인표, 박원형 and Cha Yun Yeop. "Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 23-40.

공인표; 박원형; Cha Yun Yeop. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. Journal of Korean Medicine Rehabilitation, 21(4), 23-40.

공인표; 박원형; Cha Yun Yeop. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. Journal of Korean Medicine Rehabilitation. 2011; 21(4) 23-40.

공인표, 박원형, Cha Yun Yeop. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. 2011; 21(4), 23-40.

공인표, 박원형 and Cha Yun Yeop. "Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet" Journal of Korean Medicine Rehabilitation 21, no.4 (2011) : 23-40.